321
3. The observation of
13
C NMR spectrum of the drug is a proof
that the butyl chain of irbesartan and its cyclopentyl ring are
embedded in the more flexible hydrophobic core of DPPC
bilayers.
4. After irbesartan complex is inserted into DPPC bilayers, signals
of the drug are very broad (CP experiments). On the contrary,
2-HP-β-CD is not observed giving the information that this
CD is localized on the surface of DPPC bilayers.
Fig. 2 Part of
1
H NMR spectra (0.7–2.5 ppm) of (a) irbesartan dissolved in D 2 O,
(b) 2-HP-β-CD dissolved in D 2 O, (c) irbesartan dissolved in SDS micelles, (d) IRB
complexed with 2-HP-β-CD and dissolved in D 2 O, (e) IRB complexed with
2-HP-β-CD in SDS micelles
NMR Techniques Applied to Drug: Cyclodextrin Complexation
3. The observation of
13
C NMR spectrum of the drug is a proof
that the butyl chain of irbesartan and its cyclopentyl ring are
embedded in the more flexible hydrophobic core of DPPC
bilayers.
4. After irbesartan complex is inserted into DPPC bilayers, signals
of the drug are very broad (CP experiments). On the contrary,
2-HP-β-CD is not observed giving the information that this
CD is localized on the surface of DPPC bilayers.
Fig. 2 Part of
1
H NMR spectra (0.7–2.5 ppm) of (a) irbesartan dissolved in D 2 O,
(b) 2-HP-β-CD dissolved in D 2 O, (c) irbesartan dissolved in SDS micelles, (d) IRB
complexed with 2-HP-β-CD and dissolved in D 2 O, (e) IRB complexed with
2-HP-β-CD in SDS micelles
NMR Techniques Applied to Drug: Cyclodextrin Complexation