316
abovementioned problems of peptides. The pharmaceutical interest of CDs extends also to enhance the solubility, chemical stability,
and bioavailability of poorly soluble drugs; to reduce the toxicity;
and to control the rate of release of some drugs. 2-Hydroxypropylβ-cyclodextrin (2-HP-β-CD—Fig. 1) has demonstrated improved
water solubility and is a biocompatible substance (more toxicologically favorable).
Micellar systems can solubilize poorly soluble drugs.
Consequently, it is evident that they increase bioavailability.
Therefore, micelles are used for drug delivery. Sodium dodecyl sulfate (SDS—Fig. 1) has a hydrocarbon tail and an anionic head
CH 2 CH 2
CH 2 CH 2 CH 2 CH 2
CH 2 CH 2 CH 2 CH 2
5CH 2
OSO 3 NA
Irbesartan
sodium dodecyl sulfate
2-HP-β-CD
DPPC
7
12 11
10
9
8
7
6
31
30
29
2H
2
3
4
5
11
16
15
12
13
14 17
22
21
20
19
18
27
23
24
25
26
HN
N
N
N
6
9
8
7
OH
OH
OH
OH
OH
OH
OH
O
H
OH
OH
OH
OH
OH
OH
OH
HO
HO
HO
HO
HO
HO
≡
O
1
N
N
1
2
3
4
OH
OH
1”’
2”
4”
6”
8”
10”
12”
14”
16”
2’
4’
6’
8’
10’
12’
14’
16’
1
3
2
1’
3’
5’
7’
9’
11’
13’
15’
1”
3”
5”
7”
9”
11”
13”
15”
2”’
H
H
H
HO
H O
O
11
1
2
3
4
6 5
O
OCH 2 CHCH 2
O
O
O
O
O
O
O
O P
N
+
H 3 C
Fig. 1 SDS, irbesartan, 2-HP-β-CD, and DPPC
Dimitrios Ntountaniotis et al.