313
Thomas Mavromoustakos et al. (eds.), Supramolecules in Drug Discovery and Drug Delivery: Methods and Protocols,
Methods in Molecular Biology, vol. 2207, https://doi.org/10.1007/978-1-0716-0920-0_22,
© Springer Science+Business Media, LLC, part of Springer Nature 2021
Chapter 22
Applications of NMR in Drug:Cyclodextrin Complexes
Dimitrios Ntountaniotis, Georgios Leonis, Eirini Christodoulou,
and Thomas Mavromoustakos
Abstract
NMR spectroscopy is an effective technique, applicable for studying bioactive materials or drug delivery
systems in order to obtain comprehensive details related to structural and dynamic characteristics at atomic
resolution. The applications of NMR spectroscopy have been increased considerably as a result of the
combination of advancement in technological NMR instrumentation and scientific knowledge. This chapter is dedicated to highlight the applications of NMR spectroscopy in drug:cyclodextrin complexes using
both liquid- and solid-state NMR spectroscopy.
Key words Nuclear magnetic resonance, NMR spectroscopy for liquids and solids, Cyclodextrins,
Structural properties, Drug delivery systems
1 Introduction
Nuclear magnetic resonance (NMR) spectroscopy has been a key
weapon in the armamentarium of the scientific society and industry
in order to shed light on structural details and dynamic characteristics at atomic resolution of various bioactive systems and particularly drug delivery systems [1]. NMR is an efficacious tool, which
enables scientists to obtain compelling evidence on crucial questions of molecular biology [2, 3]. Researchers make full use of
variable NMR experiments and derive benefit from a variety of
valuable information of molecular structure and molecular interactions. In this context, NMR works as a compass to orientate scientists in the maze of a complex set of information of a biological
system. A common utility of NMR is to provide all the appropriate
data to achieve a molecular structure’s elucidation. This procedure
is a result of a combinatorial approach of NMR experiments and is
often a quite intricate project. Another example of NMR application is to validate ligand binding or to distinguish and classify
ligands in mixtures of test compounds [1]. Hence, it is apparent
Thomas Mavromoustakos et al. (eds.), Supramolecules in Drug Discovery and Drug Delivery: Methods and Protocols,
Methods in Molecular Biology, vol. 2207, https://doi.org/10.1007/978-1-0716-0920-0_22,
© Springer Science+Business Media, LLC, part of Springer Nature 2021
Chapter 22
Applications of NMR in Drug:Cyclodextrin Complexes
Dimitrios Ntountaniotis, Georgios Leonis, Eirini Christodoulou,
and Thomas Mavromoustakos
Abstract
NMR spectroscopy is an effective technique, applicable for studying bioactive materials or drug delivery
systems in order to obtain comprehensive details related to structural and dynamic characteristics at atomic
resolution. The applications of NMR spectroscopy have been increased considerably as a result of the
combination of advancement in technological NMR instrumentation and scientific knowledge. This chapter is dedicated to highlight the applications of NMR spectroscopy in drug:cyclodextrin complexes using
both liquid- and solid-state NMR spectroscopy.
Key words Nuclear magnetic resonance, NMR spectroscopy for liquids and solids, Cyclodextrins,
Structural properties, Drug delivery systems
1 Introduction
Nuclear magnetic resonance (NMR) spectroscopy has been a key
weapon in the armamentarium of the scientific society and industry
in order to shed light on structural details and dynamic characteristics at atomic resolution of various bioactive systems and particularly drug delivery systems [1]. NMR is an efficacious tool, which
enables scientists to obtain compelling evidence on crucial questions of molecular biology [2, 3]. Researchers make full use of
variable NMR experiments and derive benefit from a variety of
valuable information of molecular structure and molecular interactions. In this context, NMR works as a compass to orientate scientists in the maze of a complex set of information of a biological
system. A common utility of NMR is to provide all the appropriate
data to achieve a molecular structure’s elucidation. This procedure
is a result of a combinatorial approach of NMR experiments and is
often a quite intricate project. Another example of NMR application is to validate ligand binding or to distinguish and classify
ligands in mixtures of test compounds [1]. Hence, it is apparent