283
sis and applications. John Wiley & Sons,
Hoboken, NJ, pp 283–315
96. Cavalli R, Akhter AK, Bisazza A et al (2010)
Nanosponge formulations as oxygen delivery
systems. Int J Pharm 402(1–2):254–257
97. Femminò S, Penna C, Bessone F et al (2018)
α-Cyclodextrin and α-cyclodextrin polymers
as oxygen nanocarriers to limit hypoxia/
reoxygenation injury: implications from an
in vitro model. Polymers 10(2):211
98. Mandić Z, Gabelica V (2006) Ionization,
lipophilicity and solubility properties of repaglinide. J Pharm Biomed Anal 41(3):866–871
99. Olteanu AA, Aramă CC, Radu C et al (2014)
Effect of β-cyclodextrins based nanosponges
on the solubility of lipophilic pharmacological
active substances (repaglinide). J Incl Phenom
Macrocycl Chem 80(1–2):17–24
100. Kim JS, Kim MS, Park HJ et al (2008)
Physicochemical properties and oral bioavailability of amorphous atorvastatin hemicalcium using spray-drying and SAS process.
Int J Pharm 359(1–2):211–219
101. Zidan MF, Ibrahim HM, Afouna MI et al
(2018) In vitro and in vivo evaluation of
cyclodextrin-based nanosponges for enhancing oral bioavailability of atorvastatin calcium.
Drug Dev Ind Pharm 44(8):1243–1253
102. Guéguen L, Pointillart A (2000) The bioavailability of dietary calcium. J Am Coll Nutr
19(2):119S–136S
103. Shende P, Deshmukh K, Trotta F et al (2013)
Novel cyclodextrin nanosponges for delivery
of calcium in hyperphosphatemia. Int J Pharm
465(1):95–100
104. Swaminathan S, Vavia PR, Trotta F et al
(2009) Release modulation and conformational stabilization of a model protein by use
of swellable nanosponges of β-cyclodextrin.
In: First European cyclodextrin conference,
Aalborg, Denmark
105. Gilardi G, Di Nardo G, Trotta F et al (2009)
Cyclodextrin nanosponges as a carrier for biocatalysts, and in the delivery and release of
enzymes, proteins, vaccines and antibodies.
WO2009149883 A1
106. Cavalli R, Argenziano M, Caldera F et al
(2015) β-cyclodextrin nanosponge technology for the oral delivery of insulin. In:
European conference on cyclodextrins, Lille
107. Swaminathan S, Cavalli R, Trotta F et al
(2010) In vitro release modulation and conformational stabilization of a model protein
using swellable polyamidoamine nanosponges
of b-cyclodextrin. J Incl Phenom Macrocycl
Chem 68(1–2):183–191
108. Wajs E, Caldera F, Trotta F et al (2014)
Peroxidase-encapsulated cyclodextrin nanosponge immunoconjugates as a signal
enhancement tool in optical and electrochemical assays. Analyst 139(2):375–380
109. Di Nardo G, Roggero C, Campolongo S
et al (2009) Catalytic properties of catechol
1, 2-dioxygenase from Acinetobacter radioresistens S13 immobilized on nanosponges.
Dalton Trans 33:6507–6512
110. Deshmukh K, Tanwar YS, Sharma S et al
(2016) Functionalized nanosponges for
controlled antibacterial and antihypocalcemic actions. Biomed Pharmacother
84:485–494
111. Zhu X, Shan W, Zhang P et al (2013)
Penetratin derivative-based nanocomplexes
for enhanced intestinal insulin delivery. Mol
Pharm 11(1):317–328
112. Presas E, McCartney F, Sultan E et al (2018)
Physicochemical,
pharmacokinetic
and
pharmacodynamic analyses of amphiphilic
cyclodextrin-based nanoparticles designed
to enhance intestinal delivery of insulin. J
Control Release 286:402–414
113. Swaminathan S, Vavia PR, Trotta F et al
(2013) Structural evidence of differential
forms of nanosponges of beta-cyclodextrin
and its effect on solubilization of a model
drug. J Incl Phenom Macrocycl Chem
76(1–2):201–211
114. Swaminathan S, Vavia PR, Trotta F et al
(2013) Nanosponges encapsulating dexamethasone for ocular delivery: formulation
design, physicochemical characterization,
safety and corneal permeability assessment. J
Biomed Nanotechnol 9(6):998–1007
115. Conte C, Caldera F, Catanzano O et al
(2014) β-Cyclodextrin nanosponges as multifunctional ingredient in water-containing
semisolid formulations for skin delivery. J
Pharm Sci 103(12):3941–3949
116. Alongi J, Poskovic M, Frache A et al (2011)
Role of β-cyclodextrin nanosponges in polypropylene photooxidation. Carbohydr Polym
86(1):127–135
117. Rossi B, Venuti V, D'Amico F et al (2016)
Guest–matrix interactions affect the solvation
of cyclodextrin-based polymeric hydrogels:
a UV Raman scattering study. Soft Matter
12(43):8861–8868
118. Seglie L, Martina K, Devecchi M et al (2011)
The effects of 1-MCP in cyclodextrinbased nanosponges to improve the vase
life of Dianthus caryophyllus cut flowers.
Postharvest Biol Technol 59(2):200–205
119. Arkas M, Roza A, Dimitris T et al (2006)
Organic/inorganic hybrid filters based on
dendritic and cyclodextrin “nanosponges” for
the removal of organic pollutants from water.
Environ Sci Technol 40(8):2771–2777
120. Trotta F, Caldera F, Cavalli R et al (2014)
Synthesis and characterization of a hyperbranched water-soluble β-cyclodextrin polymer. Beilstein J Org Chem 10(1):2586–2593
Drug-Encapsulated Cyclodextrin Nanosponges
sis and applications. John Wiley & Sons,
Hoboken, NJ, pp 283–315
96. Cavalli R, Akhter AK, Bisazza A et al (2010)
Nanosponge formulations as oxygen delivery
systems. Int J Pharm 402(1–2):254–257
97. Femminò S, Penna C, Bessone F et al (2018)
α-Cyclodextrin and α-cyclodextrin polymers
as oxygen nanocarriers to limit hypoxia/
reoxygenation injury: implications from an
in vitro model. Polymers 10(2):211
98. Mandić Z, Gabelica V (2006) Ionization,
lipophilicity and solubility properties of repaglinide. J Pharm Biomed Anal 41(3):866–871
99. Olteanu AA, Aramă CC, Radu C et al (2014)
Effect of β-cyclodextrins based nanosponges
on the solubility of lipophilic pharmacological
active substances (repaglinide). J Incl Phenom
Macrocycl Chem 80(1–2):17–24
100. Kim JS, Kim MS, Park HJ et al (2008)
Physicochemical properties and oral bioavailability of amorphous atorvastatin hemicalcium using spray-drying and SAS process.
Int J Pharm 359(1–2):211–219
101. Zidan MF, Ibrahim HM, Afouna MI et al
(2018) In vitro and in vivo evaluation of
cyclodextrin-based nanosponges for enhancing oral bioavailability of atorvastatin calcium.
Drug Dev Ind Pharm 44(8):1243–1253
102. Guéguen L, Pointillart A (2000) The bioavailability of dietary calcium. J Am Coll Nutr
19(2):119S–136S
103. Shende P, Deshmukh K, Trotta F et al (2013)
Novel cyclodextrin nanosponges for delivery
of calcium in hyperphosphatemia. Int J Pharm
465(1):95–100
104. Swaminathan S, Vavia PR, Trotta F et al
(2009) Release modulation and conformational stabilization of a model protein by use
of swellable nanosponges of β-cyclodextrin.
In: First European cyclodextrin conference,
Aalborg, Denmark
105. Gilardi G, Di Nardo G, Trotta F et al (2009)
Cyclodextrin nanosponges as a carrier for biocatalysts, and in the delivery and release of
enzymes, proteins, vaccines and antibodies.
WO2009149883 A1
106. Cavalli R, Argenziano M, Caldera F et al
(2015) β-cyclodextrin nanosponge technology for the oral delivery of insulin. In:
European conference on cyclodextrins, Lille
107. Swaminathan S, Cavalli R, Trotta F et al
(2010) In vitro release modulation and conformational stabilization of a model protein
using swellable polyamidoamine nanosponges
of b-cyclodextrin. J Incl Phenom Macrocycl
Chem 68(1–2):183–191
108. Wajs E, Caldera F, Trotta F et al (2014)
Peroxidase-encapsulated cyclodextrin nanosponge immunoconjugates as a signal
enhancement tool in optical and electrochemical assays. Analyst 139(2):375–380
109. Di Nardo G, Roggero C, Campolongo S
et al (2009) Catalytic properties of catechol
1, 2-dioxygenase from Acinetobacter radioresistens S13 immobilized on nanosponges.
Dalton Trans 33:6507–6512
110. Deshmukh K, Tanwar YS, Sharma S et al
(2016) Functionalized nanosponges for
controlled antibacterial and antihypocalcemic actions. Biomed Pharmacother
84:485–494
111. Zhu X, Shan W, Zhang P et al (2013)
Penetratin derivative-based nanocomplexes
for enhanced intestinal insulin delivery. Mol
Pharm 11(1):317–328
112. Presas E, McCartney F, Sultan E et al (2018)
Physicochemical,
pharmacokinetic
and
pharmacodynamic analyses of amphiphilic
cyclodextrin-based nanoparticles designed
to enhance intestinal delivery of insulin. J
Control Release 286:402–414
113. Swaminathan S, Vavia PR, Trotta F et al
(2013) Structural evidence of differential
forms of nanosponges of beta-cyclodextrin
and its effect on solubilization of a model
drug. J Incl Phenom Macrocycl Chem
76(1–2):201–211
114. Swaminathan S, Vavia PR, Trotta F et al
(2013) Nanosponges encapsulating dexamethasone for ocular delivery: formulation
design, physicochemical characterization,
safety and corneal permeability assessment. J
Biomed Nanotechnol 9(6):998–1007
115. Conte C, Caldera F, Catanzano O et al
(2014) β-Cyclodextrin nanosponges as multifunctional ingredient in water-containing
semisolid formulations for skin delivery. J
Pharm Sci 103(12):3941–3949
116. Alongi J, Poskovic M, Frache A et al (2011)
Role of β-cyclodextrin nanosponges in polypropylene photooxidation. Carbohydr Polym
86(1):127–135
117. Rossi B, Venuti V, D'Amico F et al (2016)
Guest–matrix interactions affect the solvation
of cyclodextrin-based polymeric hydrogels:
a UV Raman scattering study. Soft Matter
12(43):8861–8868
118. Seglie L, Martina K, Devecchi M et al (2011)
The effects of 1-MCP in cyclodextrinbased nanosponges to improve the vase
life of Dianthus caryophyllus cut flowers.
Postharvest Biol Technol 59(2):200–205
119. Arkas M, Roza A, Dimitris T et al (2006)
Organic/inorganic hybrid filters based on
dendritic and cyclodextrin “nanosponges” for
the removal of organic pollutants from water.
Environ Sci Technol 40(8):2771–2777
120. Trotta F, Caldera F, Cavalli R et al (2014)
Synthesis and characterization of a hyperbranched water-soluble β-cyclodextrin polymer. Beilstein J Org Chem 10(1):2586–2593
Drug-Encapsulated Cyclodextrin Nanosponges