Fig. 1 (a) Domain structure of the Janus kinases. The C-terminal JH1 domain represents the
catalytically active kinase domain, while the JH2 domain is a structurally similar pseudokinase
domain with regulatory function. The JH3 and JH4 domains possess a Src homology 2 (SH2)-like
structure, and JH5–JH7 constitute a FERM (four-point-one, ezrin, radixin, moesin) homology
domain. (b) Schematic depiction of the JAK-STAT pathway (adopted from Forster et al. [2])
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catalytically active kinase domain, while the JH2 domain is a structurally similar pseudokinase
domain with regulatory function. The JH3 and JH4 domains possess a Src homology 2 (SH2)-like
structure, and JH5–JH7 constitute a FERM (four-point-one, ezrin, radixin, moesin) homology
domain. (b) Schematic depiction of the JAK-STAT pathway (adopted from Forster et al. [2])
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