Fig. 1 (a) Tyrosine kinase domain with a typical bilobal architecture connected by the so-called
hinge region, located in the cleft between the N-lobe and the C-lobe. (b) Kinase ATP-binding
pocket with the conserved amino acid sequence Asp-Phe-Gly (DFG) in the active DFG-in and the
inactive DFG-out conformations. The backbones of hinge and gatekeeper residues are also
highlighted
Case Study on Receptor Tyrosine Kinases EGFR, VEGFR, and PDGFR
157