293
16
Jones M (2017) Herbal antibiotics. CreateSpace Publ.
Lüllmann H, Mohr K, Wehling M, Hein L (2016) Pharmakologie
und Toxikologie, 18th ed. Thieme-Verlag, Stuttgart/
New York
Karow T, Lang-Roth R (2016) Pharmakologie und Toxikologie, 25th ed. Thomas Karow Verlag, Pulheim
Beiglböck W (2016) Koffein: Genussmittel oder Suchtmittel? Springer
Brahmachari G (ed) (2015) Bioactive natural products -
chemistry and biology. Wiley-VCH
Van Boeckel TP, Brower C, Gilbert M, Grenfell BT, Levin S,
Robinson TP et al (2015) Global trends in antimicrobial use in food animals. Proc Natl Acad Sci 112:5649–
5654
Center for Disease Dynamics, Economics & Policy (2015)
State of the world’s antibiotics. CDDEP, Washington
Kalsi PS, Jagtap S (2013) Pharmaceutical medicinal & natural product chemistry. Narosa
Alagarsamy V (2012) Pharmaceutical chemistry of natural
products. Elsevier India
Knölker H-J (2012) Alkaloid-synthesis. Springer
Ohno M, Otsuka M, Okamoto Y, Yagisawa M, Kondo S
(2011) Antibiotics. In: Ullmann’s encyclopedia of
industrial chemisty. Wiley VCH Verlag
Brahmachari G (2010) Handbook of pharmaceutical natural products. Wiley-VCH
Dewick PM (2009) Medicinal natural products: a biosynthetic approach. Wiley
Kleemann A, Engel J, Kutscher B, Reichert D (2008) Pharmaceutical substances, 5th ed. Thieme Verlag, Stuttgart
Schmitz R, Friedrich C, Müller-Jahnke W-D (eds) (2005)
Geschichte der Pharmazie, vol 2. Govi-Verlag, Eschborn
Sneader W (2005) Drug discovery - a history. Wiley
Brown K (2005) Penicillin man: Alexander Fleming and the
antibiotic revolution. The History Press, Cheltenham
Hobhouse H (1992) Fünf Pflanzen verändern die Welt, dtv.
München
Pieroth I (1992) Penicillinherstellung: Von den Anfängen
bis zur Großproduktion. WVG, Stuttgart
Ferré F (1991) Kaffee: Eine Kulturgeschichte. Wasmuth
Verlag, Tübingen
Original Papers
Rudo A, Zeller K-P, Siehl H-U, Berger S, Sicker D (2018)
Chinin, ein legendäres Alkaloid. Chem unserer Zeit
52:238–248
Kleemann A, Offermanns H (2012) Meilenstein Salicylsäuresynthese. Chem unserer Zeit 46:40–47
Streller S, Roth K (2012) Eine Rinde erobert die Welt.
Chem unserer Zeit 46:228–247
Streller S, Roth K (2011) Über die Heldentaten der Hormonsucher - 50 Jahre Pille in Deutschland. Chem
unserer Zeit 45:270–291
Kuhnert N (1999) 100 Jahre Aspirin®. Chem unserer Zeit
33:213–220
? Ten Quickies
1. What do you find in the “Papyrus Ebers”?
Where does it come from? When did it
originate?
2. What is the statistical effort required
today to bring a new active
pharmaceutical ingredient onto the
market?
3. How did Rudolf Schmitt succeed in
significantly improving the yield of the
synthesis of salicylic acid developed by
Hermann Kolbe?
4. From which region does the coffee
plant originate? Which alkaloid can be
obtained from the seeds of this shrub?
How is it extracted today?
5. Why was the powdered bark of the
“cinchona bark tree” also called
“Jesuit’s powder”? What is the active
pharmaceutical ingredient in this
powder? What effects does this substance
have?
6. Describe the pharmacological properties
of morphine! Why is it only allowed to be
used in very limited diseases?
7. Who is considered the discoverer of
penicillins? How was the discovery made?
8. Compare the basic structures of
penicillins and cephalosporins! Why
are there several penicillins and
cephalosporins each?
9. Describe the basic structure of the
steroids. How is the ring system marked?
10. What are estrogens? Give an important
example! What is the structure of ring A
in estrogens?
References
Monographs and Review Articles
Ritter JM et al (2019) Rang & Dale’s pharmacology, 9th ed.
Elsevier
Cidlowski JA (ed) (2019) Steroids. Int J 150
Whalen K (2018) Pharmacology, 7th Intern. Ed. Lippincott
Williams & Wilki
Nidamboor R, Nidamboor JR (2017) Nature’s aspirin. Indus
Source Publ.
16.7 · Steroids
16
Jones M (2017) Herbal antibiotics. CreateSpace Publ.
Lüllmann H, Mohr K, Wehling M, Hein L (2016) Pharmakologie
und Toxikologie, 18th ed. Thieme-Verlag, Stuttgart/
New York
Karow T, Lang-Roth R (2016) Pharmakologie und Toxikologie, 25th ed. Thomas Karow Verlag, Pulheim
Beiglböck W (2016) Koffein: Genussmittel oder Suchtmittel? Springer
Brahmachari G (ed) (2015) Bioactive natural products -
chemistry and biology. Wiley-VCH
Van Boeckel TP, Brower C, Gilbert M, Grenfell BT, Levin S,
Robinson TP et al (2015) Global trends in antimicrobial use in food animals. Proc Natl Acad Sci 112:5649–
5654
Center for Disease Dynamics, Economics & Policy (2015)
State of the world’s antibiotics. CDDEP, Washington
Kalsi PS, Jagtap S (2013) Pharmaceutical medicinal & natural product chemistry. Narosa
Alagarsamy V (2012) Pharmaceutical chemistry of natural
products. Elsevier India
Knölker H-J (2012) Alkaloid-synthesis. Springer
Ohno M, Otsuka M, Okamoto Y, Yagisawa M, Kondo S
(2011) Antibiotics. In: Ullmann’s encyclopedia of
industrial chemisty. Wiley VCH Verlag
Brahmachari G (2010) Handbook of pharmaceutical natural products. Wiley-VCH
Dewick PM (2009) Medicinal natural products: a biosynthetic approach. Wiley
Kleemann A, Engel J, Kutscher B, Reichert D (2008) Pharmaceutical substances, 5th ed. Thieme Verlag, Stuttgart
Schmitz R, Friedrich C, Müller-Jahnke W-D (eds) (2005)
Geschichte der Pharmazie, vol 2. Govi-Verlag, Eschborn
Sneader W (2005) Drug discovery - a history. Wiley
Brown K (2005) Penicillin man: Alexander Fleming and the
antibiotic revolution. The History Press, Cheltenham
Hobhouse H (1992) Fünf Pflanzen verändern die Welt, dtv.
München
Pieroth I (1992) Penicillinherstellung: Von den Anfängen
bis zur Großproduktion. WVG, Stuttgart
Ferré F (1991) Kaffee: Eine Kulturgeschichte. Wasmuth
Verlag, Tübingen
Original Papers
Rudo A, Zeller K-P, Siehl H-U, Berger S, Sicker D (2018)
Chinin, ein legendäres Alkaloid. Chem unserer Zeit
52:238–248
Kleemann A, Offermanns H (2012) Meilenstein Salicylsäuresynthese. Chem unserer Zeit 46:40–47
Streller S, Roth K (2012) Eine Rinde erobert die Welt.
Chem unserer Zeit 46:228–247
Streller S, Roth K (2011) Über die Heldentaten der Hormonsucher - 50 Jahre Pille in Deutschland. Chem
unserer Zeit 45:270–291
Kuhnert N (1999) 100 Jahre Aspirin®. Chem unserer Zeit
33:213–220
? Ten Quickies
1. What do you find in the “Papyrus Ebers”?
Where does it come from? When did it
originate?
2. What is the statistical effort required
today to bring a new active
pharmaceutical ingredient onto the
market?
3. How did Rudolf Schmitt succeed in
significantly improving the yield of the
synthesis of salicylic acid developed by
Hermann Kolbe?
4. From which region does the coffee
plant originate? Which alkaloid can be
obtained from the seeds of this shrub?
How is it extracted today?
5. Why was the powdered bark of the
“cinchona bark tree” also called
“Jesuit’s powder”? What is the active
pharmaceutical ingredient in this
powder? What effects does this substance
have?
6. Describe the pharmacological properties
of morphine! Why is it only allowed to be
used in very limited diseases?
7. Who is considered the discoverer of
penicillins? How was the discovery made?
8. Compare the basic structures of
penicillins and cephalosporins! Why
are there several penicillins and
cephalosporins each?
9. Describe the basic structure of the
steroids. How is the ring system marked?
10. What are estrogens? Give an important
example! What is the structure of ring A
in estrogens?
References
Monographs and Review Articles
Ritter JM et al (2019) Rang & Dale’s pharmacology, 9th ed.
Elsevier
Cidlowski JA (ed) (2019) Steroids. Int J 150
Whalen K (2018) Pharmacology, 7th Intern. Ed. Lippincott
Williams & Wilki
Nidamboor R, Nidamboor JR (2017) Nature’s aspirin. Indus
Source Publ.
16.7 · Steroids