References
119
Oh R, Kim J, Lu W, Rosenthal D (2014) Anticancer effect of Fucoidan in combination with Tyrosine
Kinase Inhibitor Lapatinib. Evid Based Complement Alternat Med. 865375. https://doi.org/10.
1155/2014/865375
Park SJ, Lee KW, Lim DS, Lee S (2012) The sulfated polysaccharide fucoidan stimulates osteogenic
differentiation of human adipose-derived stem cells. Stem Cells Dev 21:2204–2211
Peng Y, Wang Y, Wang Q, Luo X, He Y, Song Y (2018) Hypolipidermic effects of sulfated fucoidan
from Kjellmaniella crassifolia through modulating the cholesterol and aliphatic metabolic
pathways. J Funct Foods 51:8–15
Pereira J, Portron S, Dizier B, Vinatier C, Masson M, Sourice S, Galy-Fauroux I, Corre P, Weiss P,
Fischer AM et al (2014) The in vitro and in vivo effects of a low-molecular-weight fucoidan on
the osteogenic capacity of human adipose-derived stromal cells. Tissue Eng Part A 20:275–284
Pinheiro AC, Bourbon AI, Cerqueira MA, Maricato E, Nunes C, Coimbra MA, Vicente AA
(2015) Chitosan/fucoidan multilayer nanocapsules as a vehicle for controlled release of bioactive
compounds. Carbohydr Polym 115:1–9
Ponce NMA, Pujol CA, Damonte EB, Flores ML, Stortz CA (2003) Fucoidans from the brown
seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies.
Carbohyd Res 338:153–165
Qin Y, Yuan Q, Zhang Y, Li J, Zhu X, Zhao L, Wen J, Liu J, Zhao L, Zhao J (2018) Enzyme-assisted
extraction optimization, characterization and antioxidant activity of polysaccharides from sea
cucumber Phyllophorus proteus. Molecules 23(590):1–19
Rodriguez-Jasso RM, Mussatto SI, Pastrana L, Aguilar CN, Teixeira JA (2010) Fucoidan-degrading
fungal strains: screening, morphometric evaluation, and influence of medium composition. Appl
Biochem Biotechnol 162:2177–2188
Rodriguez-Jasso RM, Mussatto SI, Pastrana L, Aguilar CN, Teixeira JA (2011) Microwaveassisted extraction of sulfated polysaccharides (fucoidan) from brown seaweed. Carbohyd Polym
86:1137–1144
Sanjeewa KKA, Lee JS, Kim WS, Jeon YJ (2017) The potential of brown-algae polysaccharides
for the development of anticancer agents: an update on anticancer effects reported for fucoidan
and laminaran. Carbohydr Polym 177:451–459
Senthil L, Raghu C, Arjun HA, Anantharaman P (2019) In vitro and in silico inhibition properties
of fucoidan against alpha-amylase and alpha-D-glucosidase with relevance to type 2 diabetes
mellitus. Carbohyd Polym 209:350–355
Shan L, Li J, Mao G, Yan L, Hu Y, Ye X, Tian D, Linhardt RJ, Chen S (2019) Effect of sulfation
pattern of sea cucumber-derived fucoidan oligosaccharides on modulating metabolic syndromes
and gut microbiota dysbiosis caused by HFD in mice. J Funct Foods 55:193–210
Sharma G, Kar S, Basu Ball W, Ghosh K, Das PK (2014) The curative effect of fucoidan on visceral
leishmaniasis is mediated by activation of map kinases through specific protein kinase c isoforms.
Cell Mol Immunol 11:263–274
Silchenko AS, Kusaykin MI, Kurilenko VV, Zakharenko AM, Isakov VV, Zaporozhets TS, Gazha
AK, Zvyagintseva TN (2013) Hydrolysis of fucoidan by fucoidanase isolated from the marine
bacterium, formosa algae. Mar Drugs 11:2413–2430
Sim S, Shin Y, Kim H (2019) Fucoidan from Undaria pinnatifida has anti-diabetic effects by
stimulation of glucose uptake and reduction of basal lipolysis in 3 t3-L1 adipocytes. Nutr Res (in
press)
Sinurat E, Peranginangin R, Saepudin E (2015) Purification and characterization of fucoidan from
the brown seaweed Sargassum binderi sonder. Squalen Bull Mar Fish Postharvest Biotechnol
10(2):79–87
Synytsya A, Bleha R, Synytsya A, Pohl R, Hayashi K, Yoshinaga K, Nakano T, Hayashi T (2014)
Mekabu fucoidan: Structural complexity and defensive effects against avian influenza a viruses.
Carbohydr Polym 111:633–644
Tokita Y, Nakajima K, Mochida H, Iha M, Nagamine T (2010) Development of a fucoidan-specific
antibody and measurement of fucoidan in serum and urine by Sandwich ELISA. Biosci Biotechnol
Biochem 74:350–357
119
Oh R, Kim J, Lu W, Rosenthal D (2014) Anticancer effect of Fucoidan in combination with Tyrosine
Kinase Inhibitor Lapatinib. Evid Based Complement Alternat Med. 865375. https://doi.org/10.
1155/2014/865375
Park SJ, Lee KW, Lim DS, Lee S (2012) The sulfated polysaccharide fucoidan stimulates osteogenic
differentiation of human adipose-derived stem cells. Stem Cells Dev 21:2204–2211
Peng Y, Wang Y, Wang Q, Luo X, He Y, Song Y (2018) Hypolipidermic effects of sulfated fucoidan
from Kjellmaniella crassifolia through modulating the cholesterol and aliphatic metabolic
pathways. J Funct Foods 51:8–15
Pereira J, Portron S, Dizier B, Vinatier C, Masson M, Sourice S, Galy-Fauroux I, Corre P, Weiss P,
Fischer AM et al (2014) The in vitro and in vivo effects of a low-molecular-weight fucoidan on
the osteogenic capacity of human adipose-derived stromal cells. Tissue Eng Part A 20:275–284
Pinheiro AC, Bourbon AI, Cerqueira MA, Maricato E, Nunes C, Coimbra MA, Vicente AA
(2015) Chitosan/fucoidan multilayer nanocapsules as a vehicle for controlled release of bioactive
compounds. Carbohydr Polym 115:1–9
Ponce NMA, Pujol CA, Damonte EB, Flores ML, Stortz CA (2003) Fucoidans from the brown
seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies.
Carbohyd Res 338:153–165
Qin Y, Yuan Q, Zhang Y, Li J, Zhu X, Zhao L, Wen J, Liu J, Zhao L, Zhao J (2018) Enzyme-assisted
extraction optimization, characterization and antioxidant activity of polysaccharides from sea
cucumber Phyllophorus proteus. Molecules 23(590):1–19
Rodriguez-Jasso RM, Mussatto SI, Pastrana L, Aguilar CN, Teixeira JA (2010) Fucoidan-degrading
fungal strains: screening, morphometric evaluation, and influence of medium composition. Appl
Biochem Biotechnol 162:2177–2188
Rodriguez-Jasso RM, Mussatto SI, Pastrana L, Aguilar CN, Teixeira JA (2011) Microwaveassisted extraction of sulfated polysaccharides (fucoidan) from brown seaweed. Carbohyd Polym
86:1137–1144
Sanjeewa KKA, Lee JS, Kim WS, Jeon YJ (2017) The potential of brown-algae polysaccharides
for the development of anticancer agents: an update on anticancer effects reported for fucoidan
and laminaran. Carbohydr Polym 177:451–459
Senthil L, Raghu C, Arjun HA, Anantharaman P (2019) In vitro and in silico inhibition properties
of fucoidan against alpha-amylase and alpha-D-glucosidase with relevance to type 2 diabetes
mellitus. Carbohyd Polym 209:350–355
Shan L, Li J, Mao G, Yan L, Hu Y, Ye X, Tian D, Linhardt RJ, Chen S (2019) Effect of sulfation
pattern of sea cucumber-derived fucoidan oligosaccharides on modulating metabolic syndromes
and gut microbiota dysbiosis caused by HFD in mice. J Funct Foods 55:193–210
Sharma G, Kar S, Basu Ball W, Ghosh K, Das PK (2014) The curative effect of fucoidan on visceral
leishmaniasis is mediated by activation of map kinases through specific protein kinase c isoforms.
Cell Mol Immunol 11:263–274
Silchenko AS, Kusaykin MI, Kurilenko VV, Zakharenko AM, Isakov VV, Zaporozhets TS, Gazha
AK, Zvyagintseva TN (2013) Hydrolysis of fucoidan by fucoidanase isolated from the marine
bacterium, formosa algae. Mar Drugs 11:2413–2430
Sim S, Shin Y, Kim H (2019) Fucoidan from Undaria pinnatifida has anti-diabetic effects by
stimulation of glucose uptake and reduction of basal lipolysis in 3 t3-L1 adipocytes. Nutr Res (in
press)
Sinurat E, Peranginangin R, Saepudin E (2015) Purification and characterization of fucoidan from
the brown seaweed Sargassum binderi sonder. Squalen Bull Mar Fish Postharvest Biotechnol
10(2):79–87
Synytsya A, Bleha R, Synytsya A, Pohl R, Hayashi K, Yoshinaga K, Nakano T, Hayashi T (2014)
Mekabu fucoidan: Structural complexity and defensive effects against avian influenza a viruses.
Carbohydr Polym 111:633–644
Tokita Y, Nakajima K, Mochida H, Iha M, Nagamine T (2010) Development of a fucoidan-specific
antibody and measurement of fucoidan in serum and urine by Sandwich ELISA. Biosci Biotechnol
Biochem 74:350–357