References
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Fletcher HR, Biller P, Ross AB, Adams JMM (2017) The seasonal variation of fucoidan within
three species of brown macroalgae. Algal Res-Biomass Biofuels Bioprod 22:79–86
Gibson A, Edgar JD, Neville CE, Gilchrist SE, McKinley MC, Patterson CC, Young IS, Woodside
JV (2012) Effect of fruit and vegetable consumption on immune function in older people: a
randomized controlled trial. Am J Clin Nutr 96:1429–1436
Hahn T, Schulz M, Stadtmüller R, Zayed A, Muffler K, Lang S, Ulber R (2016) A cationic dye for
the specific determination of sulfated polysaccharides. Anal Lett 49(12):1948–1962
Han YS, Lee JH, Jung JS, Noh H, Baek MJ, Ryu JM, Yoon YM, Han HJ, Lee SH (2015) Fucoidan
protects mesenchymal stem cells against oxidative stress and enhances vascular regeneration in
a murine Hindlimb ischemia model. Int J Cardiol 198:187–195
Hayashi K, Lee JB, Nakano T, Hayashi T (2013) Anti-influenza a virus characteristics of a fucoidan
from sporophyll of Undaria pinnatifida in mice with normal and compromised immunity.
Microbes Infect/Inst Pasteur 15:302–309
Huang YC, Liu TJ (2012) Mobilization of mesenchymal stem cells by stromal cell-derived factor-1
released from chitosan/tripolyphosphate/fucoidan nanoparticles. Acta Biomater 8:1048–1056
Hwang PA, Yan MD, Kuo KL, Phan NN, Lin YC (2017) A mechanism of low molecular weight
fucoidans degraded by enzymatic and acidic hydrolysis for the prevention of UVB damage. J
Appl Phycol 29:521–529
Ikeguchi M, Yamamoto M, Arai Y, Maeta Y, Ashida K, Katano K, Miki Y, Kimura T (2011)
Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or
recurrent colorectal cancer. Oncol Lett 2:319–322
Isnansetyo A, Lutfia LNF, Nursid M, Susidarti RA (2017) Cytotoxicity of fucoidan from three
tropical brown algae against breast and colon cancer cell lines. Pharmacogn J 9(1):14–20
Jeong HS, Venkatesan J, Kim SK (2013) Hydroxyapatite-fucoidan nanocomposites for bone tissue
engineering. Int J Biol Macromol 57(138–141):123
Jin JO, Zhang W, Du JY, Wong KW, Oda T, Yu Q (2014) Fucoidan can function as an adjuvant
in vivo to enhance dendritic cell maturation and function and promote antigen-specific t cell
immune responses. PLoS ONE 9:e99396
Jour TY, Purcell S, Hair C, Mills D (2012) Sea cucumber culture, farming and sea ranching in the
tropics: progress, problems and opportunities 368(369):68–81
Kambhampati S, Park W, Habtezion A (2014) Pharmacologic therapy for acute pancreatitis. World
J Gastroenterol 20:16868–16880
Kandasamy S, Khan W, Kulshreshtha G, Evans F, Critchley AT, Fitton JH, Stringer DN, Gardiner VA,
Prithiviraj B (2015) The fucose containing polymer (fcp) rich fraction of Ascophyllum nodosum
(l.) le jol. Protects caenorhabditis elegans against Pseudomonas aeruginosa by triggering innate
immune signaling pathways and suppression of pathogen virulence factors. Algae 30:147–161
Kannan RR, Arumugam R, Anantharaman P (2013) Pharmaceutical potential of a fucoidan-like
sulphated polysaccharide isolated from Halodule pinifolia. Int J Biol Macromol 62:30–34
Kasai A, Arafuka S, Koshiba N, Takahashi D, Toshima K (2015) Systematic synthesis of lowmolecular weight fucoidan derivatives and their effect on cancer cells. Org Biomol Chem
13(42):10556–10568
Kim MJ, Jeon J, Lee JS (2014a) Fucoidan prevents high-fat diet-induced obesity in animals by
suppression of fat accumulation. Phytother Res 28:137–143
Kim YW, Baek SH, Lee SH, Kim TH, Kim SY (2014b) Fucoidan, a sulfated polysaccharide,
inhibits osteoclast differentiation and function by modulating rankl signaling. Int J Mol Sci
15:18840–18855
Kimura R, Rokkaku T, Takeda S, Senba M, Mori N (2013) Cytotoxic effects of fucoidan
nanoparticles against osteosarcoma. Mar Drugs 11:4267–4278
Kusaykin MI, Burtseva YV, Svetasheva TG, Sova VV, Zvyagintseva TN (2001) Distribution of
o-glycosyl hydrolases in marine invertebrates. Enzymes of the marine mollusk Littorina kurila
that catalyze fucoidan transformation. Biochemistry (Mosc) 68:317–324
117
Fletcher HR, Biller P, Ross AB, Adams JMM (2017) The seasonal variation of fucoidan within
three species of brown macroalgae. Algal Res-Biomass Biofuels Bioprod 22:79–86
Gibson A, Edgar JD, Neville CE, Gilchrist SE, McKinley MC, Patterson CC, Young IS, Woodside
JV (2012) Effect of fruit and vegetable consumption on immune function in older people: a
randomized controlled trial. Am J Clin Nutr 96:1429–1436
Hahn T, Schulz M, Stadtmüller R, Zayed A, Muffler K, Lang S, Ulber R (2016) A cationic dye for
the specific determination of sulfated polysaccharides. Anal Lett 49(12):1948–1962
Han YS, Lee JH, Jung JS, Noh H, Baek MJ, Ryu JM, Yoon YM, Han HJ, Lee SH (2015) Fucoidan
protects mesenchymal stem cells against oxidative stress and enhances vascular regeneration in
a murine Hindlimb ischemia model. Int J Cardiol 198:187–195
Hayashi K, Lee JB, Nakano T, Hayashi T (2013) Anti-influenza a virus characteristics of a fucoidan
from sporophyll of Undaria pinnatifida in mice with normal and compromised immunity.
Microbes Infect/Inst Pasteur 15:302–309
Huang YC, Liu TJ (2012) Mobilization of mesenchymal stem cells by stromal cell-derived factor-1
released from chitosan/tripolyphosphate/fucoidan nanoparticles. Acta Biomater 8:1048–1056
Hwang PA, Yan MD, Kuo KL, Phan NN, Lin YC (2017) A mechanism of low molecular weight
fucoidans degraded by enzymatic and acidic hydrolysis for the prevention of UVB damage. J
Appl Phycol 29:521–529
Ikeguchi M, Yamamoto M, Arai Y, Maeta Y, Ashida K, Katano K, Miki Y, Kimura T (2011)
Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or
recurrent colorectal cancer. Oncol Lett 2:319–322
Isnansetyo A, Lutfia LNF, Nursid M, Susidarti RA (2017) Cytotoxicity of fucoidan from three
tropical brown algae against breast and colon cancer cell lines. Pharmacogn J 9(1):14–20
Jeong HS, Venkatesan J, Kim SK (2013) Hydroxyapatite-fucoidan nanocomposites for bone tissue
engineering. Int J Biol Macromol 57(138–141):123
Jin JO, Zhang W, Du JY, Wong KW, Oda T, Yu Q (2014) Fucoidan can function as an adjuvant
in vivo to enhance dendritic cell maturation and function and promote antigen-specific t cell
immune responses. PLoS ONE 9:e99396
Jour TY, Purcell S, Hair C, Mills D (2012) Sea cucumber culture, farming and sea ranching in the
tropics: progress, problems and opportunities 368(369):68–81
Kambhampati S, Park W, Habtezion A (2014) Pharmacologic therapy for acute pancreatitis. World
J Gastroenterol 20:16868–16880
Kandasamy S, Khan W, Kulshreshtha G, Evans F, Critchley AT, Fitton JH, Stringer DN, Gardiner VA,
Prithiviraj B (2015) The fucose containing polymer (fcp) rich fraction of Ascophyllum nodosum
(l.) le jol. Protects caenorhabditis elegans against Pseudomonas aeruginosa by triggering innate
immune signaling pathways and suppression of pathogen virulence factors. Algae 30:147–161
Kannan RR, Arumugam R, Anantharaman P (2013) Pharmaceutical potential of a fucoidan-like
sulphated polysaccharide isolated from Halodule pinifolia. Int J Biol Macromol 62:30–34
Kasai A, Arafuka S, Koshiba N, Takahashi D, Toshima K (2015) Systematic synthesis of lowmolecular weight fucoidan derivatives and their effect on cancer cells. Org Biomol Chem
13(42):10556–10568
Kim MJ, Jeon J, Lee JS (2014a) Fucoidan prevents high-fat diet-induced obesity in animals by
suppression of fat accumulation. Phytother Res 28:137–143
Kim YW, Baek SH, Lee SH, Kim TH, Kim SY (2014b) Fucoidan, a sulfated polysaccharide,
inhibits osteoclast differentiation and function by modulating rankl signaling. Int J Mol Sci
15:18840–18855
Kimura R, Rokkaku T, Takeda S, Senba M, Mori N (2013) Cytotoxic effects of fucoidan
nanoparticles against osteosarcoma. Mar Drugs 11:4267–4278
Kusaykin MI, Burtseva YV, Svetasheva TG, Sova VV, Zvyagintseva TN (2001) Distribution of
o-glycosyl hydrolases in marine invertebrates. Enzymes of the marine mollusk Littorina kurila
that catalyze fucoidan transformation. Biochemistry (Mosc) 68:317–324