including fibrosis progress through loss of epithelial homeostasis
and EMT. Aging is the biggest risk factor for both cancer and
fibrosis, and thus, with the increase in the aging population, the
associated social and economic burden is increasing dramatically,
and so too will the benefit.
Acknowledgments
Work in the lab is funded by the Spanish Ministry of Science,
Innovation and Universities (MICIU RTI2018-096501-B-I00),
Generalitat Valenciana (PROMETEOII/2017/150), and Spanish
Association against Cancer (AECC) to M.A.N. The first two grants
are co-financed by the European Regional Development
Fund, ERDF.
References
1. Brabletz T et al (2018) EMT in cancer. Nat Rev
Cancer 18(2):128–134
2. Derynck R, Weinberg RA (2019) EMT and
cancer: more than meets the eye. Dev Cell 49
(3):313–316
3. Nieto MA et al (2016) Emt: 2016. Cell 166
(1):21–45
4. Williams ED et al (2019) Controversies around
epithelial-mesenchymal plasticity in cancer
metastasis. Nat Rev Cancer 19(12):716–732
5. Lu W, Kang Y (2019) Epithelial-mesenchymal
plasticity in cancer progression and metastasis.
Dev Cell 49(3):361–374
6. Thiery JP et al (2009) Epithelial-mesenchymal
transitions in development and disease. Cell
139(5):871–890
7. Stemmler MP et al (2019) Non-redundant
functions of EMT transcription factors. Nat
Cell Biol 21(1):102–112
8. Nieto MA (2017) Context-specific roles of
EMT programmes in cancer cell dissemination.
Nat Cell Biol 19(5):416–418
9. Hay ED (1995) An overview of epitheliomesenchymal transformation. Acta Anat
(Basel) 154(1):8–20
10. Alberga A et al (1991) The snail gene required
for mesoderm formation in drosophila is
expressed dynamically in derivatives of all
three germ layers. Development 111
(4):983–992
11. Nieto MA et al (1994) Control of cell behavior
during vertebrate development by slug, a zinc
finger gene. Science 264(5160):835–839
12. Lovisa S et al (2015) Epithelial-to-mesenchymal transition induces cell cycle arrest and
parenchymal damage in renal fibrosis. Nat
Med 21(9):998–1009
13. Grande MT et al (2015) Snail1-induced partial
epithelial-to-mesenchymal transition drives
renal fibrosis in mice and can be targeted to
reverse established disease. Nat Med 21
(9):989–997
14. Montero JA et al (2005) Shield formation at
the onset of zebrafish gastrulation. Development 132(6):1187–1198
15. Scarpa E et al (2015) Cadherin switch during
EMT in neural crest cells leads to contact inhibition of locomotion via repolarization of
forces. Dev Cell 34(4):421–434
16. Campbell K, Casanova J (2015) A role for
E-cadherin in ensuring cohesive migration of
a heterogeneous population of non-epithelial
cells. Nat Commun 6:7998
17. Pastushenko I et al (2018) Identification of the
tumour transition states occurring during
EMT. Nature 556(7702):463–468
18. Padmanaban V et al (2019) E-cadherin is
required for metastasis in multiple models of
breast cancer. Nature 573(7774):439–444
19. Takeichi M (1993) Cadherins in cancer: implications for invasion and metastasis. Curr Opin
Cell Biol 5(5):806–811
Are You Interested or Afraid of Working on EMT?
27
and EMT. Aging is the biggest risk factor for both cancer and
fibrosis, and thus, with the increase in the aging population, the
associated social and economic burden is increasing dramatically,
and so too will the benefit.
Acknowledgments
Work in the lab is funded by the Spanish Ministry of Science,
Innovation and Universities (MICIU RTI2018-096501-B-I00),
Generalitat Valenciana (PROMETEOII/2017/150), and Spanish
Association against Cancer (AECC) to M.A.N. The first two grants
are co-financed by the European Regional Development
Fund, ERDF.
References
1. Brabletz T et al (2018) EMT in cancer. Nat Rev
Cancer 18(2):128–134
2. Derynck R, Weinberg RA (2019) EMT and
cancer: more than meets the eye. Dev Cell 49
(3):313–316
3. Nieto MA et al (2016) Emt: 2016. Cell 166
(1):21–45
4. Williams ED et al (2019) Controversies around
epithelial-mesenchymal plasticity in cancer
metastasis. Nat Rev Cancer 19(12):716–732
5. Lu W, Kang Y (2019) Epithelial-mesenchymal
plasticity in cancer progression and metastasis.
Dev Cell 49(3):361–374
6. Thiery JP et al (2009) Epithelial-mesenchymal
transitions in development and disease. Cell
139(5):871–890
7. Stemmler MP et al (2019) Non-redundant
functions of EMT transcription factors. Nat
Cell Biol 21(1):102–112
8. Nieto MA (2017) Context-specific roles of
EMT programmes in cancer cell dissemination.
Nat Cell Biol 19(5):416–418
9. Hay ED (1995) An overview of epitheliomesenchymal transformation. Acta Anat
(Basel) 154(1):8–20
10. Alberga A et al (1991) The snail gene required
for mesoderm formation in drosophila is
expressed dynamically in derivatives of all
three germ layers. Development 111
(4):983–992
11. Nieto MA et al (1994) Control of cell behavior
during vertebrate development by slug, a zinc
finger gene. Science 264(5160):835–839
12. Lovisa S et al (2015) Epithelial-to-mesenchymal transition induces cell cycle arrest and
parenchymal damage in renal fibrosis. Nat
Med 21(9):998–1009
13. Grande MT et al (2015) Snail1-induced partial
epithelial-to-mesenchymal transition drives
renal fibrosis in mice and can be targeted to
reverse established disease. Nat Med 21
(9):989–997
14. Montero JA et al (2005) Shield formation at
the onset of zebrafish gastrulation. Development 132(6):1187–1198
15. Scarpa E et al (2015) Cadherin switch during
EMT in neural crest cells leads to contact inhibition of locomotion via repolarization of
forces. Dev Cell 34(4):421–434
16. Campbell K, Casanova J (2015) A role for
E-cadherin in ensuring cohesive migration of
a heterogeneous population of non-epithelial
cells. Nat Commun 6:7998
17. Pastushenko I et al (2018) Identification of the
tumour transition states occurring during
EMT. Nature 556(7702):463–468
18. Padmanaban V et al (2019) E-cadherin is
required for metastasis in multiple models of
breast cancer. Nature 573(7774):439–444
19. Takeichi M (1993) Cadherins in cancer: implications for invasion and metastasis. Curr Opin
Cell Biol 5(5):806–811
Are You Interested or Afraid of Working on EMT?
27