References
1. Thiery JP, Acloque H, Huang RY et al (2009)
Epithelial-mesenchymal transitions in development and disease. Cell 139:871–890
2. Aiello NM, Kang Y (2019) Context-dependent
EMT programs in cancer metastasis. J Exp Med
216:1016–1026
3. Nieto MA, Huang RY, Jackson RA et al (2016)
Emt: 2016. Cell 166:21–45
4. Thiery JP, Sleeman JP (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7:131–142
5. Kalluri R, Weinberg RA (2009) The basics of
epithelial-mesenchymal transition. J Clin
Invest 119:1420–1428
6. Campbell K, Casanova J (2016) A common
framework for EMT and collective cell migration. Development 143:4291–4300
7. Campbell K (2018) Contribution of epithelialmesenchymal transitions to organogenesis and
cancer metastasis. Curr Opin Cell Biol
55:30–35
8. Theveneau E, Mayor R (2012) Neural crest
delamination and migration: from epitheliumto-mesenchyme transition to collective cell
migration. Dev Biol 366:34–54
9. Hutchins EJ, Kunttas E, Piacentino ML et al
(2018) Migration and diversification of the
vagal neural crest. Dev Biol 444(Suppl 1):
S98–S109
10. Pastushenko I, Blanpain C (2019) EMT transition states during tumor progression and
metastasis. Trends Cell Biol 29:212–226
11. Aiello NM, Maddipati R, Norgard RJ et al
(2018) EMT subtype influences epithelial plasticity and mode of cell migration. Dev Cell 45
(681–695):e684
12. Lu W, Kang Y (2019) Epithelial-mesenchymal
plasticity in cancer progression and metastasis.
Dev Cell 49:361–374
13. Pastushenko I, Brisebarre A, Sifrim A et al
(2018) Identification of the tumour transition
states occurring during EMT. Nature
556:463–468
14. Grigore AD, Jolly MK, Jia D et al (2016)
Tumor budding: the name is EMT. Partial
EMT. J Clin Med 5:E51
15. Lamouille S, Xu J, Derynck R (2014) Molecular mechanisms of epithelial-mesenchymal
transition. Nat Rev Mol Cell Biol 15:178–196
16. Chang R, Zhang Y, Zhang P et al (2017) Snail
acetylation by histone acetyltransferase p300 in
lung cancer. Thorac Cancer 8:131–137
17. Chen A, Wong CS, Liu MC et al (2015) The
ubiquitin ligase Siah is a novel regulator of
Zeb1 in breast cancer. Oncotarget 6:862–873
18. Sanchez-Vasquez E, Bronner ME, StroblMazzulla PH (2019) Epigenetic inactivation
of miR-203 as a key step in neural crest
epithelial-to-mesenchymal transition. Development 146:dev171017
19. Ma L, Young J, Prabhala H et al (2010) miR-9,
a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat
Cell Biol 12:247–256
20. Li J, He M, Xu W et al (2019) LINC01354
interacting with hnRNP-D contributes to the
proliferation and metastasis in colorectal cancer
through activating Wnt/beta-catenin signaling
pathway. J Exp Clin Cancer Res 38:161
21. Zhou Y, Chang R, Ji W et al (2016) Loss of
scribble promotes snail translation through
translocation of HuR and enhances cancer
drug resistance. J Biol Chem 291:291–302
22. Nagaoka K, Fujii K, Zhang H et al (2016)
CPEB1 mediates epithelial-to-mesenchyme
transition and breast cancer metastasis. Oncogene 35:2893–2901
23. Cursons J, Pillman KA, Scheer KG et al (2018)
Combinatorial targeting by MicroRNAs
co-ordinates post-transcriptional control of
EMT. Cell Syst 7(77–91):e77
24. Bocci F, Jolly MK, Tripathi SC et al (2017)
Numb prevents a complete epithelialmesenchymal transition by modulating notch
signalling. J R Soc Interface 14:20170512
25. He P, Qiu K, Jia Y (2018) Modeling of mesenchymal hybrid epithelial state and phenotypic
transitions in EMT and MET processes of cancer cells. Sci Rep 8:14323
26. Maclean AL, Hong T, Nie Q (2018) Exploring
intermediate cell states through the lens of single cells. Curr Opin Syst Biol 9:32–41
27. Jolly MK, Tripathi SC, Somarelli JA et al
(2017) Epithelial/mesenchymal plasticity:
how have quantitative mathematical models
helped improve our understanding? Mol
Oncol 11:739–754
6
Erica J. Hutchins and Marianne E. Bronner
1. Thiery JP, Acloque H, Huang RY et al (2009)
Epithelial-mesenchymal transitions in development and disease. Cell 139:871–890
2. Aiello NM, Kang Y (2019) Context-dependent
EMT programs in cancer metastasis. J Exp Med
216:1016–1026
3. Nieto MA, Huang RY, Jackson RA et al (2016)
Emt: 2016. Cell 166:21–45
4. Thiery JP, Sleeman JP (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7:131–142
5. Kalluri R, Weinberg RA (2009) The basics of
epithelial-mesenchymal transition. J Clin
Invest 119:1420–1428
6. Campbell K, Casanova J (2016) A common
framework for EMT and collective cell migration. Development 143:4291–4300
7. Campbell K (2018) Contribution of epithelialmesenchymal transitions to organogenesis and
cancer metastasis. Curr Opin Cell Biol
55:30–35
8. Theveneau E, Mayor R (2012) Neural crest
delamination and migration: from epitheliumto-mesenchyme transition to collective cell
migration. Dev Biol 366:34–54
9. Hutchins EJ, Kunttas E, Piacentino ML et al
(2018) Migration and diversification of the
vagal neural crest. Dev Biol 444(Suppl 1):
S98–S109
10. Pastushenko I, Blanpain C (2019) EMT transition states during tumor progression and
metastasis. Trends Cell Biol 29:212–226
11. Aiello NM, Maddipati R, Norgard RJ et al
(2018) EMT subtype influences epithelial plasticity and mode of cell migration. Dev Cell 45
(681–695):e684
12. Lu W, Kang Y (2019) Epithelial-mesenchymal
plasticity in cancer progression and metastasis.
Dev Cell 49:361–374
13. Pastushenko I, Brisebarre A, Sifrim A et al
(2018) Identification of the tumour transition
states occurring during EMT. Nature
556:463–468
14. Grigore AD, Jolly MK, Jia D et al (2016)
Tumor budding: the name is EMT. Partial
EMT. J Clin Med 5:E51
15. Lamouille S, Xu J, Derynck R (2014) Molecular mechanisms of epithelial-mesenchymal
transition. Nat Rev Mol Cell Biol 15:178–196
16. Chang R, Zhang Y, Zhang P et al (2017) Snail
acetylation by histone acetyltransferase p300 in
lung cancer. Thorac Cancer 8:131–137
17. Chen A, Wong CS, Liu MC et al (2015) The
ubiquitin ligase Siah is a novel regulator of
Zeb1 in breast cancer. Oncotarget 6:862–873
18. Sanchez-Vasquez E, Bronner ME, StroblMazzulla PH (2019) Epigenetic inactivation
of miR-203 as a key step in neural crest
epithelial-to-mesenchymal transition. Development 146:dev171017
19. Ma L, Young J, Prabhala H et al (2010) miR-9,
a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat
Cell Biol 12:247–256
20. Li J, He M, Xu W et al (2019) LINC01354
interacting with hnRNP-D contributes to the
proliferation and metastasis in colorectal cancer
through activating Wnt/beta-catenin signaling
pathway. J Exp Clin Cancer Res 38:161
21. Zhou Y, Chang R, Ji W et al (2016) Loss of
scribble promotes snail translation through
translocation of HuR and enhances cancer
drug resistance. J Biol Chem 291:291–302
22. Nagaoka K, Fujii K, Zhang H et al (2016)
CPEB1 mediates epithelial-to-mesenchyme
transition and breast cancer metastasis. Oncogene 35:2893–2901
23. Cursons J, Pillman KA, Scheer KG et al (2018)
Combinatorial targeting by MicroRNAs
co-ordinates post-transcriptional control of
EMT. Cell Syst 7(77–91):e77
24. Bocci F, Jolly MK, Tripathi SC et al (2017)
Numb prevents a complete epithelialmesenchymal transition by modulating notch
signalling. J R Soc Interface 14:20170512
25. He P, Qiu K, Jia Y (2018) Modeling of mesenchymal hybrid epithelial state and phenotypic
transitions in EMT and MET processes of cancer cells. Sci Rep 8:14323
26. Maclean AL, Hong T, Nie Q (2018) Exploring
intermediate cell states through the lens of single cells. Curr Opin Syst Biol 9:32–41
27. Jolly MK, Tripathi SC, Somarelli JA et al
(2017) Epithelial/mesenchymal plasticity:
how have quantitative mathematical models
helped improve our understanding? Mol
Oncol 11:739–754
6
Erica J. Hutchins and Marianne E. Bronner