3 Retinoic Acid-Regulated Target Genes During Development …
61
Table 3.1 List of the RA-regulated genes identified in ECCs and ESCs using various methods,
from the classical cDNA screening methods to the recent genome-wide and high throughput NGS
methods. If reported in the literature, the presence of RAREs in the promoter of target genes is
mentioned
Gene symbol
RARE
Identification
technique
Cell line
References
Homeobox genes
Hoxa1
DR5
cDNA screening
F9
LaRosa and Gudas
(1988)
Substractive
hybridization
P19
Bouillet et al. (1995a, b)
Affimetrix
GeneChip
F9,
mESCs
Eifert et al. (2006),
Mendoza-Parra et al.
(2011), Mahony et al.
(2011)
Illumina
BeadChips
mESCs
Kashyap et al. (2013)
RNA-seq
mESCs
Al Tanoury et al. (2014)
Hoxa2
DR5
Illumina
BeadChips
mESCs
Kashyap et al. (2013)
Affimetrix
GeneChip ®
mESCs
Mahony et al. (2011)
Illumina
BeadChips
hESCs
Fathi et al. (2011)
Hoxa3
DR5
Atlas cDNA arrays F9
Eifert et al. (2006)
Affimetrix
GeneChip ®
F9,
mESCs
Su and Gudas (2008),
Eifert et al. (2006),
Mahony et al. (2011)
RNA-seq
mESCs
Al Tanoury et al. (2014)
Hoxa4
Affimetrix
GeneChip ®
F9
mESCs
Eifert et al. (2006),
Mahony et al. (2011)
Hoxa5
DR3
Biochips
P19
Wei et al. (2002)
Affimetrix
GeneChip ®
F9
Su and Gudas (2008),
Eifert et al. (2006)
Unigene cDNA
arrays
NT2/D1
Freemantle et al. (2002)
Illumina Bead
chips
hESCs
Fathi et al. (2011)
RNA-seq
mESCs
Al Tanoury et al. (2014)
Hoxb1
DR5
Affimetrix
GeneChip ®
F9
mESCs
Eifert et al. (2006),
Mahony et al. (2011)
Illumina
BeadChips
mESCs
Kashyap et al. (2013)
RNA-seq
mESCs
Al Tanoury et al. (2014)
(continued)