6 Retinoic Acid Signaling and Development of the Respiratory System
171
Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV (2010) A retinoic acid-dependent
network in the foregut controls formation of the mouse lung primordium. J Clin Invest 120:2040–
2048
Chen F, Desai TJ, Qian J, Niederreither K, Lu J, Cardoso WV (2007) Inhibition of Tgf beta signaling
by endogenous retinoic acid is essential for primary lung bud induction. Development 134:2969–
2979
Chen F, Marquez H, Kim YK, Qian J, Shao F, Fine A, Cruikshank WW, Quadro L, Cardoso WV
(2014) Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice. J Clin
Invest 124:801–811
Clugston RD, Zhang W, Alvarez S, de Lera AR, Greer JJ (2010) Understanding abnormal retinoid
signaling as a causative mechanism in congenital diaphragmatic hernia. Am J Respir Cell Mol
Biol 42:276–285
Comroe JH (1965) Physiology of respiration, an introductory text. Year Book Medical Publishers,
Chicago
Dersch H, Zile MH (1993) Induction of normal cardiovascular development in the vitamin Adeprived quail embryo by natural retinoids. Dev Biol 160:424–433
Desai TJ, Chen F, Lu J, Qian J, Niederreither K, Dolle P, Chambon P, Cardoso WV (2006) Distinct
roles for retinoic acid receptors alpha and beta in early lung morphogenesis. Dev Biol 291:12–24
Desai TJ, Malpel S, Flentke GR, Smith SM, Cardoso WV (2004) Retinoic acid selectively regulates
Fgf10 expression and maintains cell identity in the prospective lung field of the developing
foregut. Dev Biol 273:402–415
Dickman ED, Thaller C, Smith SM (1997) Temporally-regulated retinoic acid depletion produces
specific neural crest, ocular and nervous system defects. Development 124:3111–3121
Dirami G, Massaro GD, Clerch LB, Ryan US, Reczek PR, Massaro D (2004) Lung retinol storing
cells synthesize and secrete retinoic acid, an inducer of alveolus formation. Am J Physiol Lung
Cell Mol Physiol 286:L249-256
Domyan ET, Ferretti E, Throckmorton K, Mishina Y, Nicolis SK, Sun X (2011) Signaling through
BMP receptors promotes respiratory identity in the foregut via repression of Sox2. Development
138:971–981
Fernandes-Silva H, Vaz-Cunha P, Barbosa VB, Silva-Goncalves C, Correia-Pinto J, Moura RS
(2017) Retinoic acid regulates avian lung branching through a molecular network. Cell Mol Life
Sci 74:4599-4619
Gaxiola A, Varon J, Valladolid G (2009) Congenital diaphragmatic hernia: an overview of the
etiology and current management. Acta Paediatr 98:621–627
Geevarghese SK, Chytil F (1994) Depletion of retinyl esters in the lungs coincides with lung prenatal
morphological maturation. Biochem Biophys Res Commun 200:529–535
Golzio C, Martinovic-Bouriel J, Thomas S, Mougou-Zrelli S, Grattagliano-Bessieres B, Bonniere
M, Delahaye S, Munnich A, Encha-Razavi F, Lyonnet S, Vekemans M, Attie-Bitach T, Etchevers
HC (2007) Matthew-Wood syndrome is caused by truncating mutations in the retinol-binding
protein receptor gene STRA6. Am J Hum Genet 80:1179–1187
Goss AM, Tian Y, Tsukiyama T, Cohen ED, Zhou D, Lu MM, Yamaguchi TP, Morrisey EE (2009)
Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in
the foregut. Dev Cell 17:290–298
Goumy C, Gouas L, Marceau G, Coste K, Veronese L, Gallot D, Sapin V, Vago P, Tchirkov A
(2010) Retinoid pathway and congenital diaphragmatic hernia: hypothesis from the analysis of
chromosomal abnormalities. Fetal Diagn Ther 28:129–139
Harris-Johnson KS, Domyan ET, Vezina CM, Sun X (2009) beta-Catenin promotes respiratory
progenitor identity in mouse foregut. Proc Natl Acad Sci U S A 106:16287–16292
Hsia CC, Schmitz A, Lambertz M, Perry SF, Maina JN (2013) Evolution of air breathing: oxygen
homeostasis and the transitions from water to land and sky. Compr Physiol 3:849–915
Kalter H, Warkany J (1959) Experimental production of congenital maiformations in mammals by
metabolic procedure. Physiol Rev 39:69–115
171
Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV (2010) A retinoic acid-dependent
network in the foregut controls formation of the mouse lung primordium. J Clin Invest 120:2040–
2048
Chen F, Desai TJ, Qian J, Niederreither K, Lu J, Cardoso WV (2007) Inhibition of Tgf beta signaling
by endogenous retinoic acid is essential for primary lung bud induction. Development 134:2969–
2979
Chen F, Marquez H, Kim YK, Qian J, Shao F, Fine A, Cruikshank WW, Quadro L, Cardoso WV
(2014) Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice. J Clin
Invest 124:801–811
Clugston RD, Zhang W, Alvarez S, de Lera AR, Greer JJ (2010) Understanding abnormal retinoid
signaling as a causative mechanism in congenital diaphragmatic hernia. Am J Respir Cell Mol
Biol 42:276–285
Comroe JH (1965) Physiology of respiration, an introductory text. Year Book Medical Publishers,
Chicago
Dersch H, Zile MH (1993) Induction of normal cardiovascular development in the vitamin Adeprived quail embryo by natural retinoids. Dev Biol 160:424–433
Desai TJ, Chen F, Lu J, Qian J, Niederreither K, Dolle P, Chambon P, Cardoso WV (2006) Distinct
roles for retinoic acid receptors alpha and beta in early lung morphogenesis. Dev Biol 291:12–24
Desai TJ, Malpel S, Flentke GR, Smith SM, Cardoso WV (2004) Retinoic acid selectively regulates
Fgf10 expression and maintains cell identity in the prospective lung field of the developing
foregut. Dev Biol 273:402–415
Dickman ED, Thaller C, Smith SM (1997) Temporally-regulated retinoic acid depletion produces
specific neural crest, ocular and nervous system defects. Development 124:3111–3121
Dirami G, Massaro GD, Clerch LB, Ryan US, Reczek PR, Massaro D (2004) Lung retinol storing
cells synthesize and secrete retinoic acid, an inducer of alveolus formation. Am J Physiol Lung
Cell Mol Physiol 286:L249-256
Domyan ET, Ferretti E, Throckmorton K, Mishina Y, Nicolis SK, Sun X (2011) Signaling through
BMP receptors promotes respiratory identity in the foregut via repression of Sox2. Development
138:971–981
Fernandes-Silva H, Vaz-Cunha P, Barbosa VB, Silva-Goncalves C, Correia-Pinto J, Moura RS
(2017) Retinoic acid regulates avian lung branching through a molecular network. Cell Mol Life
Sci 74:4599-4619
Gaxiola A, Varon J, Valladolid G (2009) Congenital diaphragmatic hernia: an overview of the
etiology and current management. Acta Paediatr 98:621–627
Geevarghese SK, Chytil F (1994) Depletion of retinyl esters in the lungs coincides with lung prenatal
morphological maturation. Biochem Biophys Res Commun 200:529–535
Golzio C, Martinovic-Bouriel J, Thomas S, Mougou-Zrelli S, Grattagliano-Bessieres B, Bonniere
M, Delahaye S, Munnich A, Encha-Razavi F, Lyonnet S, Vekemans M, Attie-Bitach T, Etchevers
HC (2007) Matthew-Wood syndrome is caused by truncating mutations in the retinol-binding
protein receptor gene STRA6. Am J Hum Genet 80:1179–1187
Goss AM, Tian Y, Tsukiyama T, Cohen ED, Zhou D, Lu MM, Yamaguchi TP, Morrisey EE (2009)
Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in
the foregut. Dev Cell 17:290–298
Goumy C, Gouas L, Marceau G, Coste K, Veronese L, Gallot D, Sapin V, Vago P, Tchirkov A
(2010) Retinoid pathway and congenital diaphragmatic hernia: hypothesis from the analysis of
chromosomal abnormalities. Fetal Diagn Ther 28:129–139
Harris-Johnson KS, Domyan ET, Vezina CM, Sun X (2009) beta-Catenin promotes respiratory
progenitor identity in mouse foregut. Proc Natl Acad Sci U S A 106:16287–16292
Hsia CC, Schmitz A, Lambertz M, Perry SF, Maina JN (2013) Evolution of air breathing: oxygen
homeostasis and the transitions from water to land and sky. Compr Physiol 3:849–915
Kalter H, Warkany J (1959) Experimental production of congenital maiformations in mammals by
metabolic procedure. Physiol Rev 39:69–115