18
(MDA-MB231) and lung (A549) cancer cells through reduction in expression of HIF-1α
and nuclear p65 (Rel a). Current Drug Delivery, 15(2), 286–295. https://doi.org/10.217
4/1567201814666171019104002.
Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010). Poly(ethylene glycol) in drug
delivery: Pros and cons as well as potential alternatives. Angewandte Chemie International
Edition, 49(36), 6288–6308. https://doi.org/10.1002/anie.200902672.
Kobayashi, M., Chang, Y. S., & Oka, M. (2005). A two year in vivo study of polyvinyl alcoholhydrogel (PVA-H) artificial meniscus. Biomaterials, 26(16), 3243–3248. https://doi.
org/10.1016/j.biomaterials.2004.08.028.
Kolate, A., Baradia, D., Patil, S., Vhora, I., Kore, G., & Misra, A. (2014). PEG - A versatile conjugating ligand for drugs and drug delivery systems. Journal of Controlled Release, 192, 67–81.
https://doi.org/10.1016/j.jconrel.2014.06.046.
Kumari, A., Yadav, S. K., & Yadav, S. C. (2010). Biodegradable polymeric nanoparticles based
drug delivery systems. Colloids and Surfaces B: Biointerfaces, 75(1), 1–18. https://doi.
org/10.1016/j.colsurfb.2009.09.001.
Li, N., Lu, X., Fang, M., Qiu, Z., Chen, X., Ren, L., Ouyang, P., & Chen, G. (2018). PEGylated
triacontanol substantially enhanced the pharmacokinetics of triacontanol in rats. Journal
of Agricultural and Food Chemistry, 66(33), 8722–8728. https://doi.org/10.1021/acs.
jafc.8b02684.
Li, S., & McCarthy, S. (1999). Further investigations on the hydrolytic degradation of poly(DLlactide). Biomaterials, 20(1), 35–44. https://doi.org/10.1016/s0142-9612(97)00226-3.
Li, W., Zhan, P., De Clercq, E., Lou, H., & Liu, X. (2013). Current drug research on PEGylation
with small molecular agents. Progress in Polymer Science, 38(3–4), 421–444. https://doi.
org/10.1016/j.progpolymsci.2012.07.006.
Lu, J., Huang, Y., Zhao, W., Chen, Y., Li, J., Gao, X., Venkataramanan, R., & Li, S. (2013). Design
and characterization of PEG-derivatized vitamin E as a nanomicellar formulation for delivery of
paclitaxel. Molecular Pharmaceutics, 10(8), 2880–2890. https://doi.org/10.1021/mp300729y.
Lukyanov, A. N., & Torchilin, V. P. (2004). Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. Advanced Drug Delivery Reviews, 56(9),
1273–1289. https://doi.org/10.1016/j.addr.2003.12.004.
Machinaga, N., Ashley, G. W., Reid, R., Yamasaki, A., Tanaka, K., Nakamura, K., Yabe, Y.,
Yoshigae, Y., & Santi, D. V. (2018). A controlled release system for long-acting intravitreal
delivery of small molecules. Translational Vision Science & Technology, 7(4), 21–21. https://
doi.org/10.1167/tvst.7.4.21.
Mandal, D., Shaw, T. K., Dey, G., Pal, M. M., Mukherjee, B., Bandyopadhyay, A. K., & Mandal,
M. (2018). Preferential hepatic uptake of paclitaxel-loaded poly-(D-L-lactide-co-glycolide)
nanoparticles - a possibility for hepatic drug targeting: Pharmacokinetics and biodistribution.
International Journal of Biological Macromolecules, 112, 818–830. https://doi.org/10.1016/j.
ijbiomac.2018.02.021.
Medina-O’Donnell, M., Rivas, F., Reyes-Zurita, F. J., Martinez, A., Lupianez, J. A., & Parra,
A. (2018). Diamine and PEGylated-diamine conjugates of triterpenic acids as potential anticancer agents. European Journal of Medicinal Chemistry, 148, 325–336. https://doi.org/10.1016/j.
ejmech.2018.02.044.
Medina-O’Donnell, M., Rivas, F., Reyes-Zurita, F. J., Martinez, A., Martin-Fonseca, S., GarciaGranados, A., Ferrer-Martín, R. M., Lupiañez, J. A., & Parra, A. (2016). Semi-synthesis
and antiproliferative evaluation of PEGylated pentacyclic triterpenes. European Journal of
Medicinal Chemistry, 118, 64–78. https://doi.org/10.1016/j.ejmech.2016.04.016.
Mura, S., Nicolas, J., & Couvreur, P. (2013). Stimuli-responsive nanocarriers for drug delivery.
Nature Materials, 12(11), 991–1003. https://doi.org/10.1038/nmat3776.
Nicks, F., Richel, A., Richard, G., Laurent, P., Wathelet, B., Wathelet, J.-P., & Paquot, M. (2012).
Green synthesis and antioxidant activity of new PEGylated ferulic acids. Tetrahedron Letters,
53(19), 2402–2405. https://doi.org/10.1016/j.tetlet.2012.02.118.
X. Guo et al.
(MDA-MB231) and lung (A549) cancer cells through reduction in expression of HIF-1α
and nuclear p65 (Rel a). Current Drug Delivery, 15(2), 286–295. https://doi.org/10.217
4/1567201814666171019104002.
Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010). Poly(ethylene glycol) in drug
delivery: Pros and cons as well as potential alternatives. Angewandte Chemie International
Edition, 49(36), 6288–6308. https://doi.org/10.1002/anie.200902672.
Kobayashi, M., Chang, Y. S., & Oka, M. (2005). A two year in vivo study of polyvinyl alcoholhydrogel (PVA-H) artificial meniscus. Biomaterials, 26(16), 3243–3248. https://doi.
org/10.1016/j.biomaterials.2004.08.028.
Kolate, A., Baradia, D., Patil, S., Vhora, I., Kore, G., & Misra, A. (2014). PEG - A versatile conjugating ligand for drugs and drug delivery systems. Journal of Controlled Release, 192, 67–81.
https://doi.org/10.1016/j.jconrel.2014.06.046.
Kumari, A., Yadav, S. K., & Yadav, S. C. (2010). Biodegradable polymeric nanoparticles based
drug delivery systems. Colloids and Surfaces B: Biointerfaces, 75(1), 1–18. https://doi.
org/10.1016/j.colsurfb.2009.09.001.
Li, N., Lu, X., Fang, M., Qiu, Z., Chen, X., Ren, L., Ouyang, P., & Chen, G. (2018). PEGylated
triacontanol substantially enhanced the pharmacokinetics of triacontanol in rats. Journal
of Agricultural and Food Chemistry, 66(33), 8722–8728. https://doi.org/10.1021/acs.
jafc.8b02684.
Li, S., & McCarthy, S. (1999). Further investigations on the hydrolytic degradation of poly(DLlactide). Biomaterials, 20(1), 35–44. https://doi.org/10.1016/s0142-9612(97)00226-3.
Li, W., Zhan, P., De Clercq, E., Lou, H., & Liu, X. (2013). Current drug research on PEGylation
with small molecular agents. Progress in Polymer Science, 38(3–4), 421–444. https://doi.
org/10.1016/j.progpolymsci.2012.07.006.
Lu, J., Huang, Y., Zhao, W., Chen, Y., Li, J., Gao, X., Venkataramanan, R., & Li, S. (2013). Design
and characterization of PEG-derivatized vitamin E as a nanomicellar formulation for delivery of
paclitaxel. Molecular Pharmaceutics, 10(8), 2880–2890. https://doi.org/10.1021/mp300729y.
Lukyanov, A. N., & Torchilin, V. P. (2004). Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. Advanced Drug Delivery Reviews, 56(9),
1273–1289. https://doi.org/10.1016/j.addr.2003.12.004.
Machinaga, N., Ashley, G. W., Reid, R., Yamasaki, A., Tanaka, K., Nakamura, K., Yabe, Y.,
Yoshigae, Y., & Santi, D. V. (2018). A controlled release system for long-acting intravitreal
delivery of small molecules. Translational Vision Science & Technology, 7(4), 21–21. https://
doi.org/10.1167/tvst.7.4.21.
Mandal, D., Shaw, T. K., Dey, G., Pal, M. M., Mukherjee, B., Bandyopadhyay, A. K., & Mandal,
M. (2018). Preferential hepatic uptake of paclitaxel-loaded poly-(D-L-lactide-co-glycolide)
nanoparticles - a possibility for hepatic drug targeting: Pharmacokinetics and biodistribution.
International Journal of Biological Macromolecules, 112, 818–830. https://doi.org/10.1016/j.
ijbiomac.2018.02.021.
Medina-O’Donnell, M., Rivas, F., Reyes-Zurita, F. J., Martinez, A., Lupianez, J. A., & Parra,
A. (2018). Diamine and PEGylated-diamine conjugates of triterpenic acids as potential anticancer agents. European Journal of Medicinal Chemistry, 148, 325–336. https://doi.org/10.1016/j.
ejmech.2018.02.044.
Medina-O’Donnell, M., Rivas, F., Reyes-Zurita, F. J., Martinez, A., Martin-Fonseca, S., GarciaGranados, A., Ferrer-Martín, R. M., Lupiañez, J. A., & Parra, A. (2016). Semi-synthesis
and antiproliferative evaluation of PEGylated pentacyclic triterpenes. European Journal of
Medicinal Chemistry, 118, 64–78. https://doi.org/10.1016/j.ejmech.2016.04.016.
Mura, S., Nicolas, J., & Couvreur, P. (2013). Stimuli-responsive nanocarriers for drug delivery.
Nature Materials, 12(11), 991–1003. https://doi.org/10.1038/nmat3776.
Nicks, F., Richel, A., Richard, G., Laurent, P., Wathelet, B., Wathelet, J.-P., & Paquot, M. (2012).
Green synthesis and antioxidant activity of new PEGylated ferulic acids. Tetrahedron Letters,
53(19), 2402–2405. https://doi.org/10.1016/j.tetlet.2012.02.118.
X. Guo et al.