16
few polymer-based drugs have been approved for clinical uses. Finally, these polymer composites aim to obtain stimuli-responsive (intelligent) systems to trigger the
drug release in a previously designated manner.
Acknowledgments This work was supported by Natural Science Foundation of China
(21877049), National Program for Support of Top-notch Young Professionals (W02070191),
Science and Technology Program of Guangzhou (201902020013).
Conflicts of Interest The authors declare no conflict of interest.
References
Abu-Fayyad, A., Behery, F., Sallam, A. A., Alqahtani, S., Ebrahim, H., El Sayed, K. A., Kaddoumi,
A., Sylvester, P. W., Carroll, J. L., Cardelli, J. A., & Nazzal, S. (2015). PEGylated γ-tocotrienol
isomer of vitamin E: Synthesis, characterization, in vitro cytotoxicity, and oral bioavailability. European Journal of Pharmaceutics and Biopharmaceutics, 96, 185–195. https://doi.
org/10.1016/j.ejpb.2015.07.022.
Alconcel, S. N. S., Baas, A. S., & Maynard, H. D. (2011). FDA-approved poly(ethylene glycol)–protein conjugate drugs. Polymer Chemistry, 2(7), 1442–1448. https://doi.org/10.1039/
c1py00034a.
Almeida, A. J., & Souto, E. (2007). Solid lipid nanoparticles as a drug delivery system for peptides
and proteins. Advanced Drug Delivery Reviews, 59(6), 478–490. https://doi.org/10.1016/j.
addr.2007.04.007.
Bobo, D., Robinson, K. J., Islam, J., Thurecht, K. J., & Corrie, S. R. (2016). Nanoparticle-based
medicines: A review of FDA-approved materials and clinical trials to date. Pharmaceutical
Research, 33(10), 2373–2387. https://doi.org/10.1007/s11095-016-1958-5.
Caliceti, P. (2003). Pharmacokinetic and biodistribution properties of poly(ethylene glycol)–protein conjugates. Advanced Drug Delivery Reviews, 55(10), 1261–1277. https://doi.org/10.1016/
s0169-409x(03)00108-x.
Cano, A., Ettcheto, M., Espina, M., Auladell, C., Calpena, A. C., Folch, J., Barenys, M., SánchezLópez, E., Camins, A., & García, M. L. (2018). Epigallocatechin-3-gallate loaded PEGylatedPLGA nanoparticles: A new anti-seizure strategy for temporal lobe epilepsy. Nanomedicine:
Nanotechnology, Biology and Medicine, 14(4), 1073–1085. https://doi.org/10.1016/j.
nano.2018.01.019.
Carstens, M. G., van Nostrum, C. F., Verrijk, R., De Leede, L. G., Crommelin, D. J., & Hennink,
W. E. (2008). A mechanistic study on the chemical and enzymatic degradation of PEG-oligo(εcaprolactone) micelles. Journal of Pharmaceutical Sciences, 97(1), 506–518. https://doi.
org/10.1002/jps.21092.
Castilla-Cortázar, I., Más-Estellés, J., Meseguer-Dueñas, J. M., Escobar Ivirico, J. L., Marí,
B., & Vidaurre, A. (2012). Hydrolytic and enzymatic degradation of a poly(ε-caprolactone)
network. Polymer Degradation and Stability, 97(8), 1241–1248. https://doi.org/10.1016/j.
polymdegradstab.2012.05.038.
Chen, J., Cui, Y., Xu, X., & Wang, L.-Q. (2018a). Direct and effective preparation of core-shell
PCL/PEG nanoparticles based on shell insertion strategy by using coaxial electrospray.
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 547, 1–7. https://doi.
org/10.1016/j.colsurfa.2018.03.010.
Chen, L. K., Mei, L. L., Feng, D. S., Huang, D., Tong, X., Pan, X., Zhu, C. N., & Wu, C. B. (2018b).
Anhydrous reverse micelle lecithin nanoparticles/PLGA composite microspheres for longX. Guo et al.
few polymer-based drugs have been approved for clinical uses. Finally, these polymer composites aim to obtain stimuli-responsive (intelligent) systems to trigger the
drug release in a previously designated manner.
Acknowledgments This work was supported by Natural Science Foundation of China
(21877049), National Program for Support of Top-notch Young Professionals (W02070191),
Science and Technology Program of Guangzhou (201902020013).
Conflicts of Interest The authors declare no conflict of interest.
References
Abu-Fayyad, A., Behery, F., Sallam, A. A., Alqahtani, S., Ebrahim, H., El Sayed, K. A., Kaddoumi,
A., Sylvester, P. W., Carroll, J. L., Cardelli, J. A., & Nazzal, S. (2015). PEGylated γ-tocotrienol
isomer of vitamin E: Synthesis, characterization, in vitro cytotoxicity, and oral bioavailability. European Journal of Pharmaceutics and Biopharmaceutics, 96, 185–195. https://doi.
org/10.1016/j.ejpb.2015.07.022.
Alconcel, S. N. S., Baas, A. S., & Maynard, H. D. (2011). FDA-approved poly(ethylene glycol)–protein conjugate drugs. Polymer Chemistry, 2(7), 1442–1448. https://doi.org/10.1039/
c1py00034a.
Almeida, A. J., & Souto, E. (2007). Solid lipid nanoparticles as a drug delivery system for peptides
and proteins. Advanced Drug Delivery Reviews, 59(6), 478–490. https://doi.org/10.1016/j.
addr.2007.04.007.
Bobo, D., Robinson, K. J., Islam, J., Thurecht, K. J., & Corrie, S. R. (2016). Nanoparticle-based
medicines: A review of FDA-approved materials and clinical trials to date. Pharmaceutical
Research, 33(10), 2373–2387. https://doi.org/10.1007/s11095-016-1958-5.
Caliceti, P. (2003). Pharmacokinetic and biodistribution properties of poly(ethylene glycol)–protein conjugates. Advanced Drug Delivery Reviews, 55(10), 1261–1277. https://doi.org/10.1016/
s0169-409x(03)00108-x.
Cano, A., Ettcheto, M., Espina, M., Auladell, C., Calpena, A. C., Folch, J., Barenys, M., SánchezLópez, E., Camins, A., & García, M. L. (2018). Epigallocatechin-3-gallate loaded PEGylatedPLGA nanoparticles: A new anti-seizure strategy for temporal lobe epilepsy. Nanomedicine:
Nanotechnology, Biology and Medicine, 14(4), 1073–1085. https://doi.org/10.1016/j.
nano.2018.01.019.
Carstens, M. G., van Nostrum, C. F., Verrijk, R., De Leede, L. G., Crommelin, D. J., & Hennink,
W. E. (2008). A mechanistic study on the chemical and enzymatic degradation of PEG-oligo(εcaprolactone) micelles. Journal of Pharmaceutical Sciences, 97(1), 506–518. https://doi.
org/10.1002/jps.21092.
Castilla-Cortázar, I., Más-Estellés, J., Meseguer-Dueñas, J. M., Escobar Ivirico, J. L., Marí,
B., & Vidaurre, A. (2012). Hydrolytic and enzymatic degradation of a poly(ε-caprolactone)
network. Polymer Degradation and Stability, 97(8), 1241–1248. https://doi.org/10.1016/j.
polymdegradstab.2012.05.038.
Chen, J., Cui, Y., Xu, X., & Wang, L.-Q. (2018a). Direct and effective preparation of core-shell
PCL/PEG nanoparticles based on shell insertion strategy by using coaxial electrospray.
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 547, 1–7. https://doi.
org/10.1016/j.colsurfa.2018.03.010.
Chen, L. K., Mei, L. L., Feng, D. S., Huang, D., Tong, X., Pan, X., Zhu, C. N., & Wu, C. B. (2018b).
Anhydrous reverse micelle lecithin nanoparticles/PLGA composite microspheres for longX. Guo et al.