Acknowledgments
The authors wish to express their gratitude to Lorena Barros for her
excellent technical assistance in this study. This work was supported
by the GAIN-Xunta de Galicia Project (IN607D 2017/01) and
the Spanish AEI/EU-FEDER (PID2019-103845RB-C21) project. Dr. Mo ´ nica Carrera is supported by the Ramo ´ n y Cajal contract
(Ministry of Science and Innovation of Spain).
References
1. Vermeirssen V, Van Camp J, Verstraete W
(2004) Bioavailability of angiotensin I converting enzyme inhibitory peptides. Br J Nutr
92:357–366
2. Sa ´nchez A, Vazquez A (2017) Bioactive peptides: a review. Food Qual Saf 1:29–46
3. Yamamoto N (1997) Antihypertensive peptides derived from food proteins. Biopolymers
43:129–134
4. Guang C, Phillips RD (2009) Plant foodderived angiotensin I converting enzyme
inhibitory peptides. J Agric Food Chem
57:5113–5120
5. Suarez-Jimenez GM, Burgos-Hernandez A,
Ezquerra-Brauer JM (2012) Bioactive peptides
and depsipeptides with anticancer potential:
sources from marine animals. Mar Drugs
10:963–986
6. Ryan JT, Ross RP, Bolton D, Fitzgerald GF,
Stanton C (2011) Bioactive peptides from
muscle sources: meat and fish. Nutrients
3:765–791
7. Cunsolo V, Saletti R, Muccilli V, Gallina S, Di
Francesco A, Foti S (2017) Proteins and bioactive peptides from donkey milk: the molecular
basis for its reduced allergenic properties. Food
Res Int 99:41–57
8. Moller NP, Scholz-Ahrens KE, Roos N, Schrezenmeir J (2008) Bioactive peptides and proteins from foods: indication for health effects.
Eur J Nutr 47:171–182
9. Amado IR, Va ´zquez JA, Gonza ´lez P, EstebanFerna ´ndez D, Carrera M, Pin ˜eiro C (2014)
Identification of the major ACE-inhibitory
peptides produced by enzymatic hydrolysis of
a protein concentrate from cuttlefish wastewater. Mar Drugs 12:1390–1405
10. Mora L, Gallego M, Toldra ´ F (2018) ACEIinhibitory peptides naturally generated in meat
and meat products and their health relevance.
Nutrients 10:1259
11. Carrera M, Can ˜as B, Gallardo JM (2013) The
sarcoplasmic fish proteome: pathways,
metabolic networks and potential bioactive
peptides for nutritional inferences. J Proteome
78:211–220
12. Agyei D, Tsopmo A, Udenigwe CC (2018)
Bioinformatics and peptidomics approaches to
the discovery and analysis of food-derived bioactive peptides. Anal Bioanal Chem
410:3463–3472
13. Anekthanakul K, Apiradee Hongsthong A, Jittisak Senachak J, Ruengjitchatchawalya M
(2018) SpirPep: an in silico digestion-based
platform to assist bioactive peptides discovery
from a genome-wide database. BMC Bioinformatics 19:149
14. Arena S, Renzone G, Scaloni A (2020) A multiapproach peptidomic analysis of hen egg white
reveals novel putative bioactive molecules. J
Proteome 215:103646
15. Carrera M, Ezquerra-Brauer JM, Aubourg SP
(2020) Characterization of the jumbo squid
(Dosidicus gigas) skin by-product by shotgun
proteomics and protein-based bioinformatics.
Mar Drugs 18:31
16. Gallardo JM, Carrera M, Ortea I (2013) Proteomics in food science. In: Cifuentes A
(ed) Foodomics: advanced mass spectrometry
in modern food science and nutrition. John
Wiley & Sons Inc., Hoboken, NJ, USA, pp
125–165
17. Carrera
M,
Gonza ´lez-Ferna ´ndez
A,
Magada ´n S, Mateos J, Pedro ´ s L, Medina I,
Gallardo JM (2019) Molecular characterization of B-cell epitopes for the major fish allergen, parvalbumin, by shotgun proteomics,
protein-based bioinformatics and IgE-reactive
approaches. J Proteome 200:123–133
18. Perkins DN, Pappin DJC, Creasy DM, Cottrell
JS (1999) Probability-based protein identification by searching sequence databases using
mass spectrometry data. Electrophoresis
20:3551–3567
19. Eng JK, McCormack AL, Yates JR III (1994)
An approach to correlate tandem mass spectral
222
Mo ´ nica Carrera et al.
The authors wish to express their gratitude to Lorena Barros for her
excellent technical assistance in this study. This work was supported
by the GAIN-Xunta de Galicia Project (IN607D 2017/01) and
the Spanish AEI/EU-FEDER (PID2019-103845RB-C21) project. Dr. Mo ´ nica Carrera is supported by the Ramo ´ n y Cajal contract
(Ministry of Science and Innovation of Spain).
References
1. Vermeirssen V, Van Camp J, Verstraete W
(2004) Bioavailability of angiotensin I converting enzyme inhibitory peptides. Br J Nutr
92:357–366
2. Sa ´nchez A, Vazquez A (2017) Bioactive peptides: a review. Food Qual Saf 1:29–46
3. Yamamoto N (1997) Antihypertensive peptides derived from food proteins. Biopolymers
43:129–134
4. Guang C, Phillips RD (2009) Plant foodderived angiotensin I converting enzyme
inhibitory peptides. J Agric Food Chem
57:5113–5120
5. Suarez-Jimenez GM, Burgos-Hernandez A,
Ezquerra-Brauer JM (2012) Bioactive peptides
and depsipeptides with anticancer potential:
sources from marine animals. Mar Drugs
10:963–986
6. Ryan JT, Ross RP, Bolton D, Fitzgerald GF,
Stanton C (2011) Bioactive peptides from
muscle sources: meat and fish. Nutrients
3:765–791
7. Cunsolo V, Saletti R, Muccilli V, Gallina S, Di
Francesco A, Foti S (2017) Proteins and bioactive peptides from donkey milk: the molecular
basis for its reduced allergenic properties. Food
Res Int 99:41–57
8. Moller NP, Scholz-Ahrens KE, Roos N, Schrezenmeir J (2008) Bioactive peptides and proteins from foods: indication for health effects.
Eur J Nutr 47:171–182
9. Amado IR, Va ´zquez JA, Gonza ´lez P, EstebanFerna ´ndez D, Carrera M, Pin ˜eiro C (2014)
Identification of the major ACE-inhibitory
peptides produced by enzymatic hydrolysis of
a protein concentrate from cuttlefish wastewater. Mar Drugs 12:1390–1405
10. Mora L, Gallego M, Toldra ´ F (2018) ACEIinhibitory peptides naturally generated in meat
and meat products and their health relevance.
Nutrients 10:1259
11. Carrera M, Can ˜as B, Gallardo JM (2013) The
sarcoplasmic fish proteome: pathways,
metabolic networks and potential bioactive
peptides for nutritional inferences. J Proteome
78:211–220
12. Agyei D, Tsopmo A, Udenigwe CC (2018)
Bioinformatics and peptidomics approaches to
the discovery and analysis of food-derived bioactive peptides. Anal Bioanal Chem
410:3463–3472
13. Anekthanakul K, Apiradee Hongsthong A, Jittisak Senachak J, Ruengjitchatchawalya M
(2018) SpirPep: an in silico digestion-based
platform to assist bioactive peptides discovery
from a genome-wide database. BMC Bioinformatics 19:149
14. Arena S, Renzone G, Scaloni A (2020) A multiapproach peptidomic analysis of hen egg white
reveals novel putative bioactive molecules. J
Proteome 215:103646
15. Carrera M, Ezquerra-Brauer JM, Aubourg SP
(2020) Characterization of the jumbo squid
(Dosidicus gigas) skin by-product by shotgun
proteomics and protein-based bioinformatics.
Mar Drugs 18:31
16. Gallardo JM, Carrera M, Ortea I (2013) Proteomics in food science. In: Cifuentes A
(ed) Foodomics: advanced mass spectrometry
in modern food science and nutrition. John
Wiley & Sons Inc., Hoboken, NJ, USA, pp
125–165
17. Carrera
M,
Gonza ´lez-Ferna ´ndez
A,
Magada ´n S, Mateos J, Pedro ´ s L, Medina I,
Gallardo JM (2019) Molecular characterization of B-cell epitopes for the major fish allergen, parvalbumin, by shotgun proteomics,
protein-based bioinformatics and IgE-reactive
approaches. J Proteome 200:123–133
18. Perkins DN, Pappin DJC, Creasy DM, Cottrell
JS (1999) Probability-based protein identification by searching sequence databases using
mass spectrometry data. Electrophoresis
20:3551–3567
19. Eng JK, McCormack AL, Yates JR III (1994)
An approach to correlate tandem mass spectral
222
Mo ´ nica Carrera et al.