(4):535–553.
https://doi.org/10.1002/
pmic.201000553
39. Herbrich SM, Cole RN, West KP, Schulze K,
Yager JD, Groopman JD, Christian P, Wu L,
O’Meally RN, May DH, McIntosh MW, Ruczinski I (2013) Statistical inference from multiple iTRAQ experiments without using
common reference standards. J Proteome Res
12(2):594–604. https://doi.org/10.1021/
pr300624g
40. Maes E, Hadiwikarta WW, Mertens I,
Baggerman G, Hooyberghs J, Valkenborg D
(2016) CONSTANd: a normalization method
for isobaric labeled spectra by constrained optimization.
Mol
Cell
Proteomics
15
(8):2779–2790. https://doi.org/10.1074/
mcp.M115.056911
41. Diz AP, Carvajal-Rodrı ´guez A, Skibinski DOF
(2011) Multiple hypothesis testing in proteomics: a strategy for experimental work. Mol
Cell Proteomics 10(3). https://doi.org/10.
1074/mcp.M110.004374
42. Storey JD (2002) A direct approach to false
discovery rates. J R Stat Soc B Stat Methodol
64(3):479–498. https://doi.org/10.1111/
1467-9868.00346
102
Angel P. Diz and Paula Sa ´ nchez-Marı ´n