initiated by the protonation of 149 and 150, occurs to form 146–148. Other genes for
the production of related sesterterpenoids with a 6/6/7/5-membered ring system have
also been found in the genomes of the plants Arabidopsis thaliana and Brassica
rapa [136].
10.5 5/4/5- and 4/5/5-Membered Ring Systems
A terpene cyclase designated as “spata-13,17-diene synthase” was found in the
marine bacterium Streptomyces xinghaiensis by the genome-based approach
[137]. This enzyme has the potential to produce prenylspata-13,17-diene (151),
geranylkelsoene (152), and other C 15 sesqui- and C 20 di-terpenoids. Compound
OPP
8
H
H
+
H
+
H
H
H
149
150
147
148
146
H
H
Fig. 106 Structures and formation of 146–150
60
T. Mitsuhashi and I. Abe
the production of related sesterterpenoids with a 6/6/7/5-membered ring system have
also been found in the genomes of the plants Arabidopsis thaliana and Brassica
rapa [136].
10.5 5/4/5- and 4/5/5-Membered Ring Systems
A terpene cyclase designated as “spata-13,17-diene synthase” was found in the
marine bacterium Streptomyces xinghaiensis by the genome-based approach
[137]. This enzyme has the potential to produce prenylspata-13,17-diene (151),
geranylkelsoene (152), and other C 15 sesqui- and C 20 di-terpenoids. Compound
OPP
8
H
H
+
H
+
H
H
H
149
150
147
148
146
H
H
Fig. 106 Structures and formation of 146–150
60
T. Mitsuhashi and I. Abe