Abbreviations
AD
Alzheimer’s disease
ADP
Adenosine diphosphate
AMC
7-Amino-4-methylcoumarin
ATP
Adenosine triphosphate
BIM
Bisindolylmaleimides
CPS1
Carbamoyl phosphate synthetase peptides
EC 1.5
Concentration of compound required to increase the enzyme
activity by 50%
EC 150
Effective concentration which increases the enzyme activity to
150%
EC 50
Half maximal effective concentration
FOXO3α
Forkhead O transcription factor 3 α
H3K9
Histone H3 lysine 9
HD
Huntington’s disease
HDAC
Histone deacetylase enzymes
HTS
High-throughput screening
IC 50
Half maximal inhibitory concentration
ICL-SIRT078 3-((2-Methoxynaphthalen-1-yl)methyl)-7-((pyridin-3-ylmethyl)
amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4
(3H)-one
K m
Value of substrate concentration at half maximal velocity
LPS
Lipopolysaccharides
Mn-SOD
Manganese superoxide dismutase
NAD
+
Nicotinamide adenine dinucleotide
NAM
Nicotinamide
NO
Nitric oxide
PCK, PGC-1α Peroxisome proliferator-activated receptor gamma coactivator
1-alpha Protein kinase C
PD
Parkinson’s disease
ROS
Reactive oxygen species
SAR
Structure-activity relationships
SirReal2
Sirtuin-rearranging ligand2
SIRT
Sirtuins
SIRT1
Silent information regulator type 1
STACs
Sirtuin-activating compounds
TAMRA
Tetramethylrhodamine
TNFα
Tumor necrosis factor alpha
56
M. Rahnasto-Rilla et al.