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of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR449a. Oncotarget 5:2276–2292. https://doi.org/10.18632/oncotarget.1902
135. Lan W-G, Xu D-H, Xu C et al (2016) Silencing of long non-coding RNA ANRIL inhibits
the development of multidrug resistance in gastric cancer cells. Oncol Rep 36:263–270.
https://doi.org/10.3892/or.2016.4771
136. Cheng S, Huang T, Li P et al (2017) Long non-coding RNA ANRIL promotes the proliferation, migration and invasion of human osteosarcoma cells. Exp Ther Med 14:5121–5125.
https://doi.org/10.3892/etm.2017.5123
137. Yu G, Liu G, Yuan D et al (2018) Long non-coding RNA ANRIL is associated with a poor
prognosis of osteosarcoma and promotes tumorigenesis via PI3K/Akt pathway. J Bone Oncol
11:51–55. https://doi.org/10.1016/j.jbo.2018.02.002
138. Zhai H, Fesler A, Schee K et al (2013) Clinical significance of long intergenic noncoding
RNA-p21 in colorectal Cancer. Clin Colorectal Cancer 12:261–266. https://doi.org/10.1016/j.
clcc.2013.06.003
139. Wang G, Li Z, Zhao Q et al (2014) LincRNA-p21 enhances the sensitivity of radiotherapy
for human colorectal cancer by targeting the Wnt/β-catenin signaling pathway. Oncol Rep
31:1839–1845. https://doi.org/10.3892/or.2014.3047
140. Wang J, Lei Z-J, Guo Y et al (2015) miRNA-regulated delivery of lincRNA-p21 suppresses
beta-catenin signaling and tumorigenicity of colorectal cancer stem cells. Oncotarget
6:37852–37870. https://doi.org/10.18632/oncotarget.5635
141. Wang X, Ruan Y, Wang X et al (2017) Long intragenic non-coding RNA lincRNA-p21
suppresses development of human prostate cancer. Cell Prolif 50:1–10. https://doi.org/10.
1111/cpr.12318
142. Wang X, Xu Y, Wang X et al (2017) LincRNA-p21 suppresses development of human
prostate cancer through inhibition of PKM2. Cell Prolif 50:1–10. https://doi.org/10.1111/
cpr.12395
143. Zhang Y-Y, Feng H-M (2017) MEG3 suppresses human pancreatic neuroendocrine tumor
cells growth and metastasis by down-regulation of Mir-183. Cell Physiol Biochem
44:345–356. https://doi.org/10.1159/000484906
144. Ma L, Wang F, Du C et al (2018) Long non-coding RNA MEG3 functions as a tumour
suppressor and has prognostic predictive value in human pancreatic cancer. Oncol Rep
39:1132–1140. https://doi.org/10.3892/or.2018.6178
145. Wang P, Chen D, Ma H, Li Y (2017) LncRNA MEG3 enhances cisplatin sensitivity in
non-small cell lung cancer by regulating miR-21-5p/SOX7 axis. Onco Targets Ther
10:5137–5149. https://doi.org/10.2147/OTT.S146423
146. Xia H, Qu X, Liu L et al (2018) LncRNA MEG3 promotes the sensitivity of vincristine
by inhibiting autophagy in lung cancer chemotherapy. Eur Rev Med Pharmacol Sci
22:1020–1027. https://doi.org/10.26355/eurrev_201802_14384
147. Xia Y, He Z, Liu B et al (2015) Downregulation of Meg3 enhances cisplatin resistance of
lung cancer cells through activation of the WNT/β-catenin signaling pathway. Mol Med Rep
12:4530–4537. https://doi.org/10.3892/mmr.2015.3897
148. Lu K, Li W, Liu X et al (2013) Long non-coding RNA MEG3 inhibits NSCLC cells
proliferation and induces apoptosis by affecting p53 expression. BMC Cancer 13:461
428
D. Hanly et al.