99. Xue X, Yang YA, Zhang A et al (2016) LncRNA HOTAIR enhances ER signaling and confers
tamoxifen resistance in breast cancer. Oncogene 35:2746–2755. https://doi.org/10.1038/onc.
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100. Zhang L, Song X, Wang X et al (2015) Circulating DNA of HOTAIR in serum is a novel
biomarker for breast cancer. Breast Cancer Res Treat 152:199–208. https://doi.org/10.1007/
s10549-015-3431-2
101. Liu X, Liu Z, Sun M et al (2013) The long non-coding RNA HOTAIR indicates a poor
prognosis and promotes metastasis in non-small cell lung cancer. BMC Cancer 13:464. https://
doi.org/10.1186/1471-2407-13-464
102. Liu Z, Sun M, Lu K et al (2013) The long noncoding RNA HOTAIR contributes to cisplatin
resistance of human lung adenocarcinoma cells via downregulation of p21WAF1/CIP1
expression. PLoS One 8:1–15. https://doi.org/10.1371/journal.pone.0077293
103. Zhai N, Xia Y, Yin R et al (2016) A negative regulation loop of long noncoding RNA
HOTAIR and p53 in non-small-cell lung cancer. Onco Targets Ther 9:5713–5720. https://
doi.org/10.2147/OTT.S110219
104. Liu M-Y, Li X-Q, Gao T-H et al (2016) Elevated HOTAIR expression associated with
cisplatin resistance in non-small cell lung cancer patients. J Thorac Dis 8:3314–3322.
https://doi.org/10.21037/jtd.2016.11.75
105. Wang Y, Wang H, Song T et al (2015) HOTAIR is a potential target for the treatment
of cisplatin-resistant ovarian cancer. Mol Med Rep 12:2211–2216. https://doi.org/10.3892/
mmr.2015.3562
106. Teschendorff AE, Lee S-H, Jones A et al (2015) HOTAIR and its surrogate DNA methylation
signature indicate carboplatin resistance in ovarian cancer. Genome Med 7:108. https://doi.
org/10.1186/s13073-015-0233-4
107. Wu Y, Zhang L, Zhang L et al (2015) Long non-coding RNA HOTAIR promotes tumor cell
invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous
cell carcinoma. Int J Oncol 46:2586–2594. https://doi.org/10.3892/ijo.2015.2976
108. Ge XS, Ma HJ, Zheng XH et al (2013) HOTAIR, a prognostic factor in esophageal
squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway. Cancer Sci
104:1675–1682. https://doi.org/10.1111/cas.12296
109. Lu M, Liao Y, Chen P et al (2017) Targeting LncRNA HOTAIR suppresses cancer
stemness and metastasis in oral carcinomas stem cells through modulation of. Oncotarget
8:98542–98552. https://doi.org/10.18632/oncotarget.21614
110. Geng YJ, Xie SL, Li Q et al (2011) Large intervening non-coding RNA HOTAIR is associated
with hepatocellular carcinoma progression. J Int Med Res 39:2119–2128. https://doi.org/10.
1177/147323001103900608
111. Yang Z, Zhou L, Wu L-M et al (2011) Overexpression of long non-coding RNA HOTAIR
predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation.
Ann Surg Oncol 18:1243–1250. https://doi.org/10.1245/s10434-011-1581-y
112. Battistelli C, Cicchini C, Santangelo L et al (2017) The Snail repressor recruits EZH2
to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-tomesenchymal transition. Oncogene 36:942–955. https://doi.org/10.1038/onc.2016.260
113. Li H, An J, Wu M et al (2015) LncRNA HOTAIR promotes human liver cancer stem cell
malignant growth through downregulation of SETD2. Oncotarget 6:27847–27864. https://doi.
org/10.18632/oncotarget.4443
114. Jen J, Tang Y-A, Lu Y-H et al (2017) Oct4 transcriptionally regulates the expression of long
non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression. Mol Cancer
16:104. https://doi.org/10.1186/s12943-017-0674-z
115. Schmidt LH, Spieker T, Koschmieder S et al (2011) The long noncoding MALAT-1 RNA
indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor
growth. J Thorac Oncol 6:1984–1992. https://doi.org/10.1097/JTO.0b013e3182307eac
116. Weber DG, Johnen G, Casjens S et al (2013) Evaluation of long noncoding RNA MALAT1
as a candidate blood-based biomarker for the diagnosis of non-small cell lung cancer. BMC
Res Notes 6:518. https://doi.org/10.1186/1756-0500-6-518
426
D. Hanly et al.
tamoxifen resistance in breast cancer. Oncogene 35:2746–2755. https://doi.org/10.1038/onc.
2015.340
100. Zhang L, Song X, Wang X et al (2015) Circulating DNA of HOTAIR in serum is a novel
biomarker for breast cancer. Breast Cancer Res Treat 152:199–208. https://doi.org/10.1007/
s10549-015-3431-2
101. Liu X, Liu Z, Sun M et al (2013) The long non-coding RNA HOTAIR indicates a poor
prognosis and promotes metastasis in non-small cell lung cancer. BMC Cancer 13:464. https://
doi.org/10.1186/1471-2407-13-464
102. Liu Z, Sun M, Lu K et al (2013) The long noncoding RNA HOTAIR contributes to cisplatin
resistance of human lung adenocarcinoma cells via downregulation of p21WAF1/CIP1
expression. PLoS One 8:1–15. https://doi.org/10.1371/journal.pone.0077293
103. Zhai N, Xia Y, Yin R et al (2016) A negative regulation loop of long noncoding RNA
HOTAIR and p53 in non-small-cell lung cancer. Onco Targets Ther 9:5713–5720. https://
doi.org/10.2147/OTT.S110219
104. Liu M-Y, Li X-Q, Gao T-H et al (2016) Elevated HOTAIR expression associated with
cisplatin resistance in non-small cell lung cancer patients. J Thorac Dis 8:3314–3322.
https://doi.org/10.21037/jtd.2016.11.75
105. Wang Y, Wang H, Song T et al (2015) HOTAIR is a potential target for the treatment
of cisplatin-resistant ovarian cancer. Mol Med Rep 12:2211–2216. https://doi.org/10.3892/
mmr.2015.3562
106. Teschendorff AE, Lee S-H, Jones A et al (2015) HOTAIR and its surrogate DNA methylation
signature indicate carboplatin resistance in ovarian cancer. Genome Med 7:108. https://doi.
org/10.1186/s13073-015-0233-4
107. Wu Y, Zhang L, Zhang L et al (2015) Long non-coding RNA HOTAIR promotes tumor cell
invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous
cell carcinoma. Int J Oncol 46:2586–2594. https://doi.org/10.3892/ijo.2015.2976
108. Ge XS, Ma HJ, Zheng XH et al (2013) HOTAIR, a prognostic factor in esophageal
squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway. Cancer Sci
104:1675–1682. https://doi.org/10.1111/cas.12296
109. Lu M, Liao Y, Chen P et al (2017) Targeting LncRNA HOTAIR suppresses cancer
stemness and metastasis in oral carcinomas stem cells through modulation of. Oncotarget
8:98542–98552. https://doi.org/10.18632/oncotarget.21614
110. Geng YJ, Xie SL, Li Q et al (2011) Large intervening non-coding RNA HOTAIR is associated
with hepatocellular carcinoma progression. J Int Med Res 39:2119–2128. https://doi.org/10.
1177/147323001103900608
111. Yang Z, Zhou L, Wu L-M et al (2011) Overexpression of long non-coding RNA HOTAIR
predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation.
Ann Surg Oncol 18:1243–1250. https://doi.org/10.1245/s10434-011-1581-y
112. Battistelli C, Cicchini C, Santangelo L et al (2017) The Snail repressor recruits EZH2
to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-tomesenchymal transition. Oncogene 36:942–955. https://doi.org/10.1038/onc.2016.260
113. Li H, An J, Wu M et al (2015) LncRNA HOTAIR promotes human liver cancer stem cell
malignant growth through downregulation of SETD2. Oncotarget 6:27847–27864. https://doi.
org/10.18632/oncotarget.4443
114. Jen J, Tang Y-A, Lu Y-H et al (2017) Oct4 transcriptionally regulates the expression of long
non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression. Mol Cancer
16:104. https://doi.org/10.1186/s12943-017-0674-z
115. Schmidt LH, Spieker T, Koschmieder S et al (2011) The long noncoding MALAT-1 RNA
indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor
growth. J Thorac Oncol 6:1984–1992. https://doi.org/10.1097/JTO.0b013e3182307eac
116. Weber DG, Johnen G, Casjens S et al (2013) Evaluation of long noncoding RNA MALAT1
as a candidate blood-based biomarker for the diagnosis of non-small cell lung cancer. BMC
Res Notes 6:518. https://doi.org/10.1186/1756-0500-6-518
426
D. Hanly et al.