m
6 A
N
6 -adenosine methylation
MALAT1
Metastasis-associated lung adenocarcinoma transcript 1
METTL3
Methyltransferase-Like 3
MIAT
Myocardial infarction-associated transcript
miRNA
microRNA
MMP9
Matrix metalloproteinase 9
MRE
miRNA recognition element
NAT
Natural antisense transcript
ncRNA
Non-coding RNA
NSCLC
Non-small-cell lung cancer
Nt
Nucleotides
OC
Ovarian cancer
pHLIP
pH-low insertion peptide
piRNA
Piwi-interacting RNA
PNA
Peptide nucleic acid
PRC
Polycomb Repressive Complex
RBMP
RNA-binding motif protein
RCC
Renal cell carcinoma
SF1
Splicing factor 1
siRNA
Short interfering RNA
SMA
Spinal muscular atrophy
SMN
Survival motor neuron
SR
Serine/arginine
SRSF
Serine/arginine splicing factor
SSO
Splice-switching oligonucleotide
TAD
Topologically associating domains
TfR
Transferrin receptor
TLS
Translocated in liposarcoma
TMZ
Temozolomide
T-UCR
Transcribed ultraconserved region
TUG1
Taurine Upregulated Gene 1
XCI
X-chromosome inactivation
YTHDC1
YTH domain containing 1
1 Introduction
One of the most striking discoveries of the postgenomic era has been that most
of the human genome is transcribed into non-coding RNA (ncRNA), the “dark
matter” of the genome, while scarcely 2% consists of protein-coding genes [1].
The non-coding transcriptome spans a vast size range. Some ncRNAs such
as miRNAs and Piwi-interacting RNAs (piRNA) are shorter than 40 nucleotides
(nt), while long non-coding RNAs (lncRNAs), arbitrarily defined as almost any
Altered Long Non-coding RNA Expression in Cancer: Potential Biomarkers. . .
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