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199. Shen Z, Sathyan KM, Geng Y, Zheng R, Chakraborty A, Freeman B, Wang F, Prasanth KV,
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72(2):247–260. https://doi.org/10.1016/0092-8674(93)90664-C
201. Mersman DP, Du HN, Fingerman IM, South PF, Briggs SD (2012) Charge-based interaction
conserved within histone H3 lysine 4 (H3K4) methyltransferase complexes is needed for
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202. Guccione E, Bassi C, Casadio F, Martinato F, Cesaroni M, Schuchlautz H, Luscher B, Amati B
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203. Migliori V, Muller J, Phalke S, Low D, Bezzi M, Mok WC, Sahu SK, Gunaratne J, Capasso P,
Bassi C, Cecatiello V, De Marco A, Blackstock W, Kuznetsov V, Amati B, Mapelli M,
Guccione E (2012) Symmetric dimethylation of H3R2 is a newly identified histone mark
that supports euchromatin maintenance. Nat Struct Mol Biol 19(2):136–144. https://doi.org/
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204. Schapira M, Tyers M, Torrent M, Arrowsmith CH (2017) WD40 repeat domain proteins:
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205. Dou Y, Milne TA, Ruthenburg AJ, Lee S, Lee JW, Verdine GL, Allis CD, Roeder RG (2006)
Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol
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206. Steward MM, Lee JS, O’Donovan A, Wyatt M, Bernstein BE, Shilatifard A (2006) Molecular
regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nat Struct
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207. Ruthenburg AJ, Allis CD, Wysocka J (2007) Methylation of lysine 4 on histone H3: intricacy
of writing and reading a single epigenetic mark. Mol Cell 25(1):15–30. https://doi.org/10.
1016/j.molcel.2006.12.014
208. Patel A, Dharmarajan V, Vought VE, Cosgrove MS (2009) On the mechanism of multiple
lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
J Biol Chem 284(36):24242–24256. https://doi.org/10.1074/jbc.M109.014498
209. Wysocka J, Swigut T, Milne TA, Dou Y, Zhang X, Burlingame AL, Roeder RG,
Brivanlou AH, Allis CD (2005) WDR5 associates with histone H3 methylated at K4 and is
essential for H3 K4 methylation and vertebrate development. Cell 121(6):859–872. https://doi.
org/10.1016/j.cell.2005.03.036
210. Couture JF, Collazo E, Trievel RC (2006) Molecular recognition of histone H3 by the WD40
protein WDR5. Nat Struct Mol Biol 13(8):698–703. https://doi.org/10.1038/nsmb1116
211. Schuetz A, Allali-Hassani A, Martin F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN,
Arrowsmith CH, Min J (2006) Structural basis for molecular recognition and presentation of
histone H3 by WDR5. EMBO J 25(18):4245–4252. https://doi.org/10.1038/sj.emboj.7601316
212. Guelman S, Kozuka K, Mao Y, Pham V, Solloway MJ, Wang J, Wu J, Lill JR, Zha J (2009)
The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Mol Cell Biol 29(5):1176–1188. https://doi.org/10.1128/MCB.01599-08
213. Cai Y, Jin J, Swanson SK, Cole MD, Choi SH, Florens L, Washburn MP, Conaway JW,
Conaway RC (2010) Subunit composition and substrate specificity of a MOF-containing
396
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networks. Trends Biochem Sci 35(10):565–574. https://doi.org/10.1016/j.tibs.2010.04.003
197. Pryer NK, Salama NR, Schekman R, Kaiser CA (1993) Cytosolic Sec13p complex is required
for vesicle formation from the endoplasmic reticulum in vitro. J Cell Biol 120(4):865–875.
https://doi.org/10.1083/jcb.120.4.865
198. de Hostos EL, Rehfuess C, Bradtke B, Waddell DR, Albrecht R, Murphy J, Gerisch G (1993)
Dictyostelium mutants lacking the cytoskeletal protein coronin are defective in cytokinesis and
cell motility. J Cell Biol 120(1):163–173. https://doi.org/10.1083/jcb.120.1.163
199. Shen Z, Sathyan KM, Geng Y, Zheng R, Chakraborty A, Freeman B, Wang F, Prasanth KV,
Prasanth SG (2010) A WD-repeat protein stabilizes ORC binding to chromatin. Mol Cell
40(1):99–111. https://doi.org/10.1016/j.molcel.2010.09.021
200. Hoey T, Weinzierl RO, Gill G, Chen JL, Dynlacht BD, Tjian R (1993) Molecular cloning
and functional analysis of Drosophila TAF110 reveal properties expected of coactivators. Cell
72(2):247–260. https://doi.org/10.1016/0092-8674(93)90664-C
201. Mersman DP, Du HN, Fingerman IM, South PF, Briggs SD (2012) Charge-based interaction
conserved within histone H3 lysine 4 (H3K4) methyltransferase complexes is needed for
protein stability, histone methylation, and gene expression. J Biol Chem 287(4):2652–2665.
https://doi.org/10.1074/jbc.M111.280867
202. Guccione E, Bassi C, Casadio F, Martinato F, Cesaroni M, Schuchlautz H, Luscher B, Amati B
(2007) Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually
exclusive. Nature 449(7164):933–937. https://doi.org/10.1038/nature06166
203. Migliori V, Muller J, Phalke S, Low D, Bezzi M, Mok WC, Sahu SK, Gunaratne J, Capasso P,
Bassi C, Cecatiello V, De Marco A, Blackstock W, Kuznetsov V, Amati B, Mapelli M,
Guccione E (2012) Symmetric dimethylation of H3R2 is a newly identified histone mark
that supports euchromatin maintenance. Nat Struct Mol Biol 19(2):136–144. https://doi.org/
10.1038/nsmb.2209
204. Schapira M, Tyers M, Torrent M, Arrowsmith CH (2017) WD40 repeat domain proteins:
a novel target class? Nat Rev Drug Discov 16(11):773–786. https://doi.org/10.1038/nrd.
2017.179
205. Dou Y, Milne TA, Ruthenburg AJ, Lee S, Lee JW, Verdine GL, Allis CD, Roeder RG (2006)
Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol
Biol 13(8):713–719. https://doi.org/10.1038/nsmb1128
206. Steward MM, Lee JS, O’Donovan A, Wyatt M, Bernstein BE, Shilatifard A (2006) Molecular
regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nat Struct
Mol Biol 13(9):852–854. https://doi.org/10.1038/nsmb1131
207. Ruthenburg AJ, Allis CD, Wysocka J (2007) Methylation of lysine 4 on histone H3: intricacy
of writing and reading a single epigenetic mark. Mol Cell 25(1):15–30. https://doi.org/10.
1016/j.molcel.2006.12.014
208. Patel A, Dharmarajan V, Vought VE, Cosgrove MS (2009) On the mechanism of multiple
lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
J Biol Chem 284(36):24242–24256. https://doi.org/10.1074/jbc.M109.014498
209. Wysocka J, Swigut T, Milne TA, Dou Y, Zhang X, Burlingame AL, Roeder RG,
Brivanlou AH, Allis CD (2005) WDR5 associates with histone H3 methylated at K4 and is
essential for H3 K4 methylation and vertebrate development. Cell 121(6):859–872. https://doi.
org/10.1016/j.cell.2005.03.036
210. Couture JF, Collazo E, Trievel RC (2006) Molecular recognition of histone H3 by the WD40
protein WDR5. Nat Struct Mol Biol 13(8):698–703. https://doi.org/10.1038/nsmb1116
211. Schuetz A, Allali-Hassani A, Martin F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN,
Arrowsmith CH, Min J (2006) Structural basis for molecular recognition and presentation of
histone H3 by WDR5. EMBO J 25(18):4245–4252. https://doi.org/10.1038/sj.emboj.7601316
212. Guelman S, Kozuka K, Mao Y, Pham V, Solloway MJ, Wang J, Wu J, Lill JR, Zha J (2009)
The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Mol Cell Biol 29(5):1176–1188. https://doi.org/10.1128/MCB.01599-08
213. Cai Y, Jin J, Swanson SK, Cole MD, Choi SH, Florens L, Washburn MP, Conaway JW,
Conaway RC (2010) Subunit composition and substrate specificity of a MOF-containing
396
G. Sbardella