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10.1126/science.1231573
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Oliveira TY, Chait BT, Nussenzweig A, Casellas R, Robbiani DF, Nussenzweig MC (2013)
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.
Science 339(6120):711–715. https://doi.org/10.1126/science.1230624
119. Ward IM, Reina-San-Martin B, Olaru A, Minn K, Tamada K, Lau JS, Cascalho M, Chen L,
Nussenzweig A, Livak F, Nussenzweig MC, Chen J (2004) 53BP1 is required for class switch
recombination. J Cell Biol 165(4):459–464. https://doi.org/10.1083/jcb.200403021
120. Dimitrova N, Chen YC, Spector DL, de Lange T (2008) 53BP1 promotes non-homologous
end joining of telomeres by increasing chromatin mobility. Nature 456(7221):524–528.
https://doi.org/10.1038/nature07433
121. Bunting SF, Callen E, Wong N, Chen HT, Polato F, Gunn A, Bothmer A, Feldhahn N,
Fernandez-Capetillo O, Cao L, Xu X, Deng CX, Finkel T, Nussenzweig M, Stark JM,
Nussenzweig A (2010) 53BP1 inhibits homologous recombination in Brca1-deficient cells
by blocking resection of DNA breaks. Cell 141(2):243–254. https://doi.org/10.1016/j.cell.
2010.03.012
122. Sanders SL, Jennings J, Canutescu A, Link AJ, Weil PA (2002) Proteomics of the eukaryotic
transcription machinery: identification of proteins associated with components of yeast TFIID
by multidimensional mass spectrometry. Mol Cell Biol 22(13):4723–4738. https://doi.org/10.
1128/mcb.22.13.4723-4738.2002
390
G. Sbardella
doi.org/10.1016/j.molcel.2012.11.026
108. Musselman CA, Avvakumov N, Watanabe R, Abraham CG, Lalonde ME, Hong Z, Allen C,
Roy S, Nunez JK, Nickoloff J, Kulesza CA, Yasui A, Cote J, Kutateladze TG (2012)
Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Nat Struct Mol
Biol 19(12):1266–1272. https://doi.org/10.1038/nsmb.2435
109. Cui G, Park S, Badeaux AI, Kim D, Lee J, Thompson JR, Yan F, Kaneko S, Yuan Z, Botuyan
MV, Bedford MT, Cheng JQ, Mer G (2012) PHF20 is an effector protein of p53 double lysine
methylation that stabilizes and activates p53. Nat Struct Mol Biol 19(9):916–924. https://doi.
org/10.1038/nsmb.2353
110. Zhang T, Park KA, Li Y, Byun HS, Jeon J, Lee Y, Hong JH, Kim JM, Huang SM, Choi SW,
Kim SH, Sohn KC, Ro H, Lee JH, Lu T, Stark GR, Shen HM, Liu ZG, Park J, Hur GM (2013)
PHF20 regulates NF-kappaB signalling by disrupting recruitment of PP2A to p65. Nat
Commun 4:2062. https://doi.org/10.1038/ncomms3062
111. Badeaux AI, Yang Y, Cardenas K, Vemulapalli V, Chen K, Kusewitt D, Richie E, Li W,
Bedford MT (2012) Loss of the methyl lysine effector protein PHF20 impacts the expression
of genes regulated by the lysine acetyltransferase MOF. J Biol Chem 287(1):429–437. https://
doi.org/10.1074/jbc.M111.271163
112. Park S, Kim D, Dan HC, Chen H, Testa JR, Cheng JQ (2012) Identification of Akt interaction
protein PHF20/TZP that transcriptionally regulates p53. J Biol Chem 287(14):11151–11163.
https://doi.org/10.1074/jbc.M111.333922
113. Zhao W, Li Q, Ayers S, Gu Y, Shi Z, Zhu Q, Chen Y, Wang HY, Wang RF (2013) Jmjd3
inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for
ubiquitination. Cell 152(5):1037–1050. https://doi.org/10.1016/j.cell.2013.02.006
114. Charier G, Couprie J, Alpha-Bazin B, Meyer V, Quemeneur E, Guerois R, Callebaut I,
Gilquin B, Zinn-Justin S (2004) The Tudor tandem of 53BP1: a new structural motif involved
in DNA and RG-rich peptide binding. Structure 12(9):1551–1562. https://doi.org/10.1016/j.
str.2004.06.014
115. Panier S, Boulton SJ (2014) Double-strand break repair: 53BP1 comes into focus. Nat Rev
Mol Cell Biol 15(1):7–18. https://doi.org/10.1038/nrm3719
116. Huo Q, Yang Q (2011) P53-binding protein 1: a new player for tumorigenesis and a new target
for breast cancer treatment. Med Hypotheses 77(3):359–363. https://doi.org/10.1016/j.mehy.
2011.05.015
117. Zimmermann M, Lottersberger F, Buonomo SB, Sfeir A, de Lange T (2013) 53BP1 regulates
DSB repair using Rif1 to control 5
0 end resection. Science 339(6120):700–704. https://doi.org/
10.1126/science.1231573
118. Di Virgilio M, Callen E, Yamane A, Zhang W, Jankovic M, Gitlin AD, Feldhahn N, Resch W,
Oliveira TY, Chait BT, Nussenzweig A, Casellas R, Robbiani DF, Nussenzweig MC (2013)
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.
Science 339(6120):711–715. https://doi.org/10.1126/science.1230624
119. Ward IM, Reina-San-Martin B, Olaru A, Minn K, Tamada K, Lau JS, Cascalho M, Chen L,
Nussenzweig A, Livak F, Nussenzweig MC, Chen J (2004) 53BP1 is required for class switch
recombination. J Cell Biol 165(4):459–464. https://doi.org/10.1083/jcb.200403021
120. Dimitrova N, Chen YC, Spector DL, de Lange T (2008) 53BP1 promotes non-homologous
end joining of telomeres by increasing chromatin mobility. Nature 456(7221):524–528.
https://doi.org/10.1038/nature07433
121. Bunting SF, Callen E, Wong N, Chen HT, Polato F, Gunn A, Bothmer A, Feldhahn N,
Fernandez-Capetillo O, Cao L, Xu X, Deng CX, Finkel T, Nussenzweig M, Stark JM,
Nussenzweig A (2010) 53BP1 inhibits homologous recombination in Brca1-deficient cells
by blocking resection of DNA breaks. Cell 141(2):243–254. https://doi.org/10.1016/j.cell.
2010.03.012
122. Sanders SL, Jennings J, Canutescu A, Link AJ, Weil PA (2002) Proteomics of the eukaryotic
transcription machinery: identification of proteins associated with components of yeast TFIID
by multidimensional mass spectrometry. Mol Cell Biol 22(13):4723–4738. https://doi.org/10.
1128/mcb.22.13.4723-4738.2002
390
G. Sbardella