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Nat Struct Mol Biol 17(6):666–672. https://doi.org/10.1038/nsmb.1842
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19. Musselman CA, Lalonde M-E, Cote J, Kutateladze TG (2012) Perceiving the epigenetic
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82(1):81–118. https://doi.org/10.1146/annurev-biochem-072711-165700
23. Schindler U, Beckmann H, Cashmore AR (1993) HAT3.1, a novel Arabidopsis homeodomain
protein containing a conserved cysteine-rich region. Plant J 4(1):137–150. https://doi.org/10.
1046/j.1365-313X.1993.04010137.x
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Sci 36(7):364–372. https://doi.org/10.1016/j.tibs.2011.03.005
26. Oppikofer M, Sagolla M, Haley B, Zhang HM, Kummerfeld SK, Sudhamsu J, Flynn EM,
Bai T, Zhang J, Ciferri C, Cochran AG (2017) Non-canonical reader modules of BAZ1A
promote recovery from DNA damage. Nat Commun 8(1):862. https://doi.org/10.1038/
s41467-017-00866-0
27. Li H, Ilin S, Wang W, Duncan EM, Wysocka J, Allis CD, Patel DJ (2006) Molecular basis
for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature
442(7098):91–95. https://doi.org/10.1038/nature04802
28. Pena PV, Davrazou F, Shi X, Walter KL, Verkhusha VV, Gozani O, Zhao R, Kutateladze TG
(2006) Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of
ING2. Nature 442(7098):100–103. https://doi.org/10.1038/nature04814
29. Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T, Carney D, Pena P, Lan F,
Kaadige MR, Lacoste N, Cayrou C, Davrazou F, Saha A, Cairns BR, Ayer DE, Kutateladze
TG, Shi Y, Cote J, Chua KF, Gozani O (2006) ING2 PHD domain links histone H3 lysine
4 methylation to active gene repression. Nature 442(7098):96–99. https://doi.org/10.1038/
nature04835
384
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13(1):37–50. https://doi.org/10.1038/nrc3409
12. Molina-Serrano D, Schiza V, Kirmizis A (2013) Cross-talk among epigenetic modifications:
lessons from histone arginine methylation. Biochem Soc Trans 41(3):751–759. https://doi.org/
10.1042/BST20130003
13. Dawson MA, Kouzarides T (2012) Cancer epigenetics: from mechanism to therapy. Cell
150(1):12–27. https://doi.org/10.1016/j.cell.2012.06.013
14. Anderson D, Koch CA, Grey L, Ellis C, Moran MF, Pawson T (1990) Binding of SH2
domains of phospholipase C gamma l, GAP, and Src to activated growth factor receptors.
Science 250(4983):979–982
15. Deribe YL, Pawson T, Dikic I (2010) Post-translational modifications in signal integration.
Nat Struct Mol Biol 17(6):666–672. https://doi.org/10.1038/nsmb.1842
16. Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC, Kouzarides T
(2001) Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Nature 410(6824):120–124. https://doi.org/10.1038/35065138
17. Lachner M, O’Carroll D, Rea S, Mechtler K, Jenuwein T (2001) Methylation of histone H3
lysine 9 creates a binding site for HP1 proteins. Nature 410(6824):116–120. https://doi.org/10.
1038/35065132
18. Nakayama J, Rice JC, Strahl BD, Allis CD, Grewal SI (2001) Role of histone H3
lysine 9 methylation in epigenetic control of heterochromatin assembly. Science
292(5514):110–113. https://doi.org/10.1126/science.1060118
19. Musselman CA, Lalonde M-E, Cote J, Kutateladze TG (2012) Perceiving the epigenetic
landscape through histone readers. Nat Struct Mol Biol 19(12):1218–1227
20. Bae N, Viviano M, Su X, Lv J, Cheng D, Sagum C, Castellano S, Bai X, Johnson C, Khalil MI,
Shen J, Chen K, Li H, Sbardella G, Bedford MT (2017) Developing Spindlin1 small-molecule
inhibitors by using protein microarrays. Nat Chem Biol 13(7):750–756. https://doi.org/10.
1038/nchembio.2377
21. Musselman CA, Khorasanizadeh S, Kutateladze TG (2014) Towards understanding
methyllysine readout. Biochim Biophys Acta 1839(8):686–693. https://doi.org/10.1016/j.
bbagrm.2014.04.001
22. Patel DJ, Wang Z (2013) Readout of epigenetic modifications. Annu Rev Biochem
82(1):81–118. https://doi.org/10.1146/annurev-biochem-072711-165700
23. Schindler U, Beckmann H, Cashmore AR (1993) HAT3.1, a novel Arabidopsis homeodomain
protein containing a conserved cysteine-rich region. Plant J 4(1):137–150. https://doi.org/10.
1046/j.1365-313X.1993.04010137.x
24. Letunic I, Bork P (2018) 20 years of the SMART protein domain annotation resource. Nucleic
Acids Res 46(D1):D493–D496. https://doi.org/10.1093/nar/gkx922
25. Sanchez R, Zhou MM (2011) The PHD finger: a versatile epigenome reader. Trends Biochem
Sci 36(7):364–372. https://doi.org/10.1016/j.tibs.2011.03.005
26. Oppikofer M, Sagolla M, Haley B, Zhang HM, Kummerfeld SK, Sudhamsu J, Flynn EM,
Bai T, Zhang J, Ciferri C, Cochran AG (2017) Non-canonical reader modules of BAZ1A
promote recovery from DNA damage. Nat Commun 8(1):862. https://doi.org/10.1038/
s41467-017-00866-0
27. Li H, Ilin S, Wang W, Duncan EM, Wysocka J, Allis CD, Patel DJ (2006) Molecular basis
for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature
442(7098):91–95. https://doi.org/10.1038/nature04802
28. Pena PV, Davrazou F, Shi X, Walter KL, Verkhusha VV, Gozani O, Zhao R, Kutateladze TG
(2006) Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of
ING2. Nature 442(7098):100–103. https://doi.org/10.1038/nature04814
29. Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T, Carney D, Pena P, Lan F,
Kaadige MR, Lacoste N, Cayrou C, Davrazou F, Saha A, Cairns BR, Ayer DE, Kutateladze
TG, Shi Y, Cote J, Chua KF, Gozani O (2006) ING2 PHD domain links histone H3 lysine
4 methylation to active gene repression. Nature 442(7098):96–99. https://doi.org/10.1038/
nature04835
384
G. Sbardella