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state analogues to produce chemical scaffolds for PRMT inhibitors. Philos Trans R Soc Lond
B Biol Sci 373:20170072. https://doi.org/10.1098/rstb.2017.0072
95. Miletić V, Odorčić I, Nikolić P, Svedružić ŽM (2017) In silico design of the first
DNA-independent mechanism-based inhibitor of mammalian DNA methyltransferase Dnmt
1. PLoS One 12:e0174410. https://doi.org/10.1371/journal.pone.0174410
96. Halby L, Menon Y, Rilova E et al (2017) Rational design of bisubstrate-type analogues as
inhibitors of DNA methyltransferases in cancer cells. J Med Chem 60:4665–4679. https://doi.
org/10.1021/acs.jmedchem.7b00176
97. Ganesan A (2016) Multitarget drugs: an epigenetic epiphany. ChemMedChem 11:1227–1241.
https://doi.org/10.1002/cmdc.201500394
98. Rotili D, Tarantino D, Marrocco B et al (2014) Properly substituted analogues of BIX-01294
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methyltransferase 3A activity. PLoS One 9:e96941. https://doi.org/10.1371/journal.pone.
0096941
99. San José-Enériz E, Agirre X, Rabal O et al (2017) Discovery of first-in-class reversible dual
small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat
Commun 8:15424. https://doi.org/10.1038/ncomms15424
100. Yuan Z, Sun Q, Li D et al (2017) Design, synthesis and anticancer potential of NSC-319745
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https://doi.org/10.1016/J.EJMECH.2017.04.017
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methyltransferase inhibitors. Epi-informatics. Elsevier, Amsterdam, pp 53–73
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HMT crosstalk challenge. Biomol Ther 7:3. https://doi.org/10.3390/biom7010003
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mammalian brain. Neuron 86:1369–1384. https://doi.org/10.1016/j.neuron.2015.05.018
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paternal genome. Nature 403:501–502. https://doi.org/10.1038/35000656
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fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia
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107. Ito S, Shen L, Dai Q et al (2011) Tet proteins can convert 5-methylcytosine to
5-formylcytosine and 5-carboxylcytosine. Science 333:1300–1303. https://doi.org/10.1126/
science.1210597
108. Sudhamalla B, Dey D, Breski M, Islam K (2017) A rapid mass spectrometric method for the
measurement of catalytic activity of ten-eleven translocation enzymes. Anal Biochem
534:28–35. https://doi.org/10.1016/j.ab.2017.06.011
109. He Y-F, Li B-Z, Li Z et al (2011) Tet-mediated formation of 5-carboxylcytosine and its
excision by TDG in mammalian DNA. Science 333:1303–1307
110. Ito S, D’alessio AC, Taranova OV et al (2010) Role of Tet proteins in 5mC to 5hmC
conversion, ES-cell self-renewal and inner cell mass specification. Nature 466:1129–1133.
https://doi.org/10.1038/nature09303
111. Iyer LM, Zhang D, Maxwell Burroughs A, Aravind L (2013) Computational identification of
novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA. Nucleic Acids Res 41:7635–7655. https://doi.org/10.1093/nar/gkt573
112. Hashimoto H, Pais JE, Zhang X et al (2014) Structure of a Naegleria Tet-like dioxygenase in
complex with 5-methylcytosine DNA. Nature 506:391–395. https://doi.org/10.1038/
nature12905
Chemical Compounds Targeting DNA Methylation and Hydroxymethylation
283