11. Black JC, Manning AL, Van Rechem C et al (2013) KDM4A lysine demethylase induces sitespecific copy gain and rereplication of regions amplified in tumors. Cell 154:541–555. https://
doi.org/10.1016/j.cell.2013.06.051
12. Young LC, Hendzel MJ (2012) The oncogenic potential of Jumonji D2 (JMJD2/KDM4)
histone demethylase overexpression. Biochem Cell Biol 91:369–377. https://doi.org/10.1139/
bcb-2012-0054
13. Young LC, McDonald DW, Hendzel MJ (2013) Kdm4b histone demethylase is a DNA damage
response protein and confers a survival advantage following γ-irradiation. J Biol Chem
288:21376–21388. https://doi.org/10.1074/jbc.M113.491514
14. Coffey K, Rogerson L, Ryan-Munden C et al (2013) The lysine demethylase, KDM4B, is a key
molecule in androgen receptor signalling and turnover. Nucleic Acids Res 41:4433–4446
15. Italiano A, Attias R, Aurias A et al (2006) Molecular cytogenetic characterization of a
metastatic lung sarcomatoid carcinoma: 9p23 neocentromere and 9p23$p24 amplification
including JAK2 and JMJD2C. Cancer Genet Cytogenet 167:122–130. https://doi.org/10.
1016/j.cancergencyto.2006.01.004
16. Liu G, Bollig-Fischer A, Kreike B et al (2009) Genomic amplification and oncogenic properties
of the GASC1 histone demethylase gene in breast cancer. Oncogene 28:4491
17. Vinatzer U, Gollinger M, Müllauer L et al (2008) Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3. Clin
Cancer Res 14:6426–6431
18. Yang Z-Q, Imoto I, Fukuda Y et al (2000) Identification of a novel gene, GASC1, within an
amplicon at 9p23–24 frequently detected in esophageal cancer cell lines. Cancer Res
60:4735–4739
19. Wang GG, Song J, Wang Z et al (2009) Haematopoietic malignancies caused by dysregulation
of a chromatin-binding PHD finger. Nature 459:847–851. https://doi.org/10.1038/nature08036
20. Liang X, Zeng J, Wang L et al (2013) Histone demethylase retinoblastoma binding protein 2 is
overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212. PLoS
One 8:e69784
21. Teng Y-C, Lee C-F, Li Y-S et al (2013) Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis. Cancer Res 73:4711–4721
22. Zeng J, Ge Z, Wang L et al (2010) The histone demethylase RBP2 is overexpressed in gastric
cancer and its inhibition triggers senescence of cancer cells. Gastroenterology 138:981–992.
https://doi.org/10.1053/j.gastro.2009.10.004
23. Roesch A, Fukunaga-Kalabis M, Schmidt EC et al (2010) A temporarily distinct subpopulation
of slow-cycling melanoma cells is required for continuous tumor growth. Cell 141:583–594.
https://doi.org/10.1016/j.cell.2010.04.020
24. Angela B, Bente M, John C et al (2002) PLU-1 nuclear protein, which is upregulated in breast
cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?
Int J Cancer 101:581–588. https://doi.org/10.1002/ijc.10644
25. Wang L, Mao Y, Du G et al (2015) Overexpression of JARID1B is associated with poor
prognosis and chemotherapy resistance in epithelial ovarian cancer. Tumor Biol 36:2465–2472.
https://doi.org/10.1007/s13277-014-2859-z
26. Madsen B, Tarsounas M, Burchell JM et al (2003) PLU-1, a transcriptional repressor and
putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis.
Chromosoma 112:124–132. https://doi.org/10.1007/s00412-003-0252-6
27. Blair LP, Cao J, Zou MR et al (2011) Epigenetic regulation by lysine demethylase 5 (KDM5)
enzymes in cancer. Cancers (Basel) 3:1383–1404. https://doi.org/10.3390/cancers3011383
28. Rasmussen PB, Staller P (2014) The KDM5 family of histone demethylases as targets in
oncology drug discovery. Epigenomics 6:277–286. https://doi.org/10.2217/epi.14.14
29. Li J, Yu B, Deng P et al (2017) KDM3 epigenetically controls tumorigenic potentials of human
colorectal cancer stem cells through Wnt/β-catenin signalling. Nat Commun 8:15146
250
M. Wright et al.
doi.org/10.1016/j.cell.2013.06.051
12. Young LC, Hendzel MJ (2012) The oncogenic potential of Jumonji D2 (JMJD2/KDM4)
histone demethylase overexpression. Biochem Cell Biol 91:369–377. https://doi.org/10.1139/
bcb-2012-0054
13. Young LC, McDonald DW, Hendzel MJ (2013) Kdm4b histone demethylase is a DNA damage
response protein and confers a survival advantage following γ-irradiation. J Biol Chem
288:21376–21388. https://doi.org/10.1074/jbc.M113.491514
14. Coffey K, Rogerson L, Ryan-Munden C et al (2013) The lysine demethylase, KDM4B, is a key
molecule in androgen receptor signalling and turnover. Nucleic Acids Res 41:4433–4446
15. Italiano A, Attias R, Aurias A et al (2006) Molecular cytogenetic characterization of a
metastatic lung sarcomatoid carcinoma: 9p23 neocentromere and 9p23$p24 amplification
including JAK2 and JMJD2C. Cancer Genet Cytogenet 167:122–130. https://doi.org/10.
1016/j.cancergencyto.2006.01.004
16. Liu G, Bollig-Fischer A, Kreike B et al (2009) Genomic amplification and oncogenic properties
of the GASC1 histone demethylase gene in breast cancer. Oncogene 28:4491
17. Vinatzer U, Gollinger M, Müllauer L et al (2008) Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3. Clin
Cancer Res 14:6426–6431
18. Yang Z-Q, Imoto I, Fukuda Y et al (2000) Identification of a novel gene, GASC1, within an
amplicon at 9p23–24 frequently detected in esophageal cancer cell lines. Cancer Res
60:4735–4739
19. Wang GG, Song J, Wang Z et al (2009) Haematopoietic malignancies caused by dysregulation
of a chromatin-binding PHD finger. Nature 459:847–851. https://doi.org/10.1038/nature08036
20. Liang X, Zeng J, Wang L et al (2013) Histone demethylase retinoblastoma binding protein 2 is
overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212. PLoS
One 8:e69784
21. Teng Y-C, Lee C-F, Li Y-S et al (2013) Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis. Cancer Res 73:4711–4721
22. Zeng J, Ge Z, Wang L et al (2010) The histone demethylase RBP2 is overexpressed in gastric
cancer and its inhibition triggers senescence of cancer cells. Gastroenterology 138:981–992.
https://doi.org/10.1053/j.gastro.2009.10.004
23. Roesch A, Fukunaga-Kalabis M, Schmidt EC et al (2010) A temporarily distinct subpopulation
of slow-cycling melanoma cells is required for continuous tumor growth. Cell 141:583–594.
https://doi.org/10.1016/j.cell.2010.04.020
24. Angela B, Bente M, John C et al (2002) PLU-1 nuclear protein, which is upregulated in breast
cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?
Int J Cancer 101:581–588. https://doi.org/10.1002/ijc.10644
25. Wang L, Mao Y, Du G et al (2015) Overexpression of JARID1B is associated with poor
prognosis and chemotherapy resistance in epithelial ovarian cancer. Tumor Biol 36:2465–2472.
https://doi.org/10.1007/s13277-014-2859-z
26. Madsen B, Tarsounas M, Burchell JM et al (2003) PLU-1, a transcriptional repressor and
putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis.
Chromosoma 112:124–132. https://doi.org/10.1007/s00412-003-0252-6
27. Blair LP, Cao J, Zou MR et al (2011) Epigenetic regulation by lysine demethylase 5 (KDM5)
enzymes in cancer. Cancers (Basel) 3:1383–1404. https://doi.org/10.3390/cancers3011383
28. Rasmussen PB, Staller P (2014) The KDM5 family of histone demethylases as targets in
oncology drug discovery. Epigenomics 6:277–286. https://doi.org/10.2217/epi.14.14
29. Li J, Yu B, Deng P et al (2017) KDM3 epigenetically controls tumorigenic potentials of human
colorectal cancer stem cells through Wnt/β-catenin signalling. Nat Commun 8:15146
250
M. Wright et al.