184. Daitoku H, Hatta M, Matsuzaki H et al (2004) Silent information regulator 2 potentiates
Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A 101
(27):10042–10047. https://doi.org/10.1073/pnas.0400593101
185. Gan L, Han Y, Bastianetto S et al (2005) FoxO-dependent and -independent mechanisms
mediate SirT1 effects on IGFBP-1 gene expression. Biochem Biophys Res Commun 337
(4):1092–1096. https://doi.org/10.1016/j.bbrc.2005.09.169
186. Kobayashi Y, Furukawa-Hibi Y, Chen C et al (2005) SIRT1 is critical regulator of FOXOmediated transcription in response to oxidative stress. Int J Mol Med 16(2):237–243. https://
doi.org/10.3892/ijmm.16.2.237
187. Chen Y, Zhang J, Lin Y et al (2011) Tumour suppressor SIRT3 deacetylates and activates
manganese superoxide dismutase to scavenge ROS. EMBO Rep 12(6):534–541. https://doi.
org/10.1038/embor.2011.65
188. Pillai VB, Samant S, Sundaresan NR et al (2015) Honokiol blocks and reverses cardiac
hypertrophy in mice by activating mitochondrial Sirt3. Nat Commun 6:6656. https://doi.org/
10.1038/ncomms7656
189. Lu J, Zhang H, Chen X et al (2017) A small molecule activator of SIRT3 promotes
deacetylation and activation of manganese superoxide dismutase. Free Radic Biol Med
112:287–297. https://doi.org/10.1016/j.freeradbiomed.2017.07.012
190. Rahnasto-Rilla M, McLoughlin P, Kulikowicz T et al (2017) The identification of a SIRT6
activator from brown algae Fucus distichus. Mar Drugs 15(6):E190. https://doi.org/10.3390/
md15060190
191. Valente S, Mellini P, Spallotta F et al (2016) 1,4-Dihydropyridines active on the SIRT1/
AMPK pathway ameliorate skin repair and mitochondrial function and exhibit inhibition of
proliferation in cancer cells. J Med Chem 59(4):1471–1491. https://doi.org/10.1021/acs.
jmedchem.5b01117
192. Nayagam VM, Wang X, Tan YC et al (2006) SIRT1 modulating compounds from highthroughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen 11
(8):959–967. https://doi.org/10.1177/1087057106294710
92
M. Rahnasto-Rilla et al.
Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A 101
(27):10042–10047. https://doi.org/10.1073/pnas.0400593101
185. Gan L, Han Y, Bastianetto S et al (2005) FoxO-dependent and -independent mechanisms
mediate SirT1 effects on IGFBP-1 gene expression. Biochem Biophys Res Commun 337
(4):1092–1096. https://doi.org/10.1016/j.bbrc.2005.09.169
186. Kobayashi Y, Furukawa-Hibi Y, Chen C et al (2005) SIRT1 is critical regulator of FOXOmediated transcription in response to oxidative stress. Int J Mol Med 16(2):237–243. https://
doi.org/10.3892/ijmm.16.2.237
187. Chen Y, Zhang J, Lin Y et al (2011) Tumour suppressor SIRT3 deacetylates and activates
manganese superoxide dismutase to scavenge ROS. EMBO Rep 12(6):534–541. https://doi.
org/10.1038/embor.2011.65
188. Pillai VB, Samant S, Sundaresan NR et al (2015) Honokiol blocks and reverses cardiac
hypertrophy in mice by activating mitochondrial Sirt3. Nat Commun 6:6656. https://doi.org/
10.1038/ncomms7656
189. Lu J, Zhang H, Chen X et al (2017) A small molecule activator of SIRT3 promotes
deacetylation and activation of manganese superoxide dismutase. Free Radic Biol Med
112:287–297. https://doi.org/10.1016/j.freeradbiomed.2017.07.012
190. Rahnasto-Rilla M, McLoughlin P, Kulikowicz T et al (2017) The identification of a SIRT6
activator from brown algae Fucus distichus. Mar Drugs 15(6):E190. https://doi.org/10.3390/
md15060190
191. Valente S, Mellini P, Spallotta F et al (2016) 1,4-Dihydropyridines active on the SIRT1/
AMPK pathway ameliorate skin repair and mitochondrial function and exhibit inhibition of
proliferation in cancer cells. J Med Chem 59(4):1471–1491. https://doi.org/10.1021/acs.
jmedchem.5b01117
192. Nayagam VM, Wang X, Tan YC et al (2006) SIRT1 modulating compounds from highthroughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen 11
(8):959–967. https://doi.org/10.1177/1087057106294710
92
M. Rahnasto-Rilla et al.