4 Aptamer-Based Drug Delivery Systems
87
Fig. 4.5 Schematic representation of aptamer modified drug-loaded nanocarriers. a Aptamerfunctionalized AuNP-based nanoparticles for the combination of chemotherapy and phototherapy.
Reprinted with permission from Ref. [53] Copyright 2019, Acta Materialia Inc. b Aptamer-gold
nanoparticles. Reprinted with permission from Ref. [55] Copyright 2016, The Royal Society of
Chemistry. c MSNs loaded with drugs and modified with aptamers. Reprinted with permission from
Ref. [58] Copyright 2015, Elsevier. d Aptamer-conjugated superparamagnetic magnetic nanoparticles for magnetic resonance imaging and targeted magneto dynamic therapy of cancer. Reprinted
with permission from Ref. [63] Copyright 2020, MDPI. e The assembly of aptamer-decorated
MOFs nanoparticles for cancer therapy. Reprinted with permission from Ref. [66] Copyright 2019,
MDPI. f ATP aptamer-modified GO for intracellular ATP detection. Reprinted with permission
from Ref. [67] Copyright 2014, American Chemical Society. g GO loaded with drug and modified
with aptamers for chemo-photothermal synergetic cancer therapy. Reprinted with permission from
Ref. [69] Copyright 2020, The Royal Society of Chemistry
became a promising and novel theranostic platform for delivering anticancer drugs
and tracking nanocarriers.
4.4.1.2 Mesoporous Silica Nanoparticles (MSNs)
Mesoporous silica nanoparticles (MSNs) are commonly used carriers in drug delivery
systems, featuring with homogeneous and tunable mesopore diameter, regular pore
structure, stable skeleton structure, easily modified inner and outer surface, and no
obvious physiological toxicity. Besides, MSNs possess remarkable stability and high
drug loading efficiency. MSNs have a large specific surface area and specific pore
volume. It can load various drugs in the channel, which can slow the release of drug
and improve the durability of efficacy [56, 57]. Xie and his co-workers [58] fabricated MSNs loaded with DOX and modified with aptamer for targeting the EpCAM
87
Fig. 4.5 Schematic representation of aptamer modified drug-loaded nanocarriers. a Aptamerfunctionalized AuNP-based nanoparticles for the combination of chemotherapy and phototherapy.
Reprinted with permission from Ref. [53] Copyright 2019, Acta Materialia Inc. b Aptamer-gold
nanoparticles. Reprinted with permission from Ref. [55] Copyright 2016, The Royal Society of
Chemistry. c MSNs loaded with drugs and modified with aptamers. Reprinted with permission from
Ref. [58] Copyright 2015, Elsevier. d Aptamer-conjugated superparamagnetic magnetic nanoparticles for magnetic resonance imaging and targeted magneto dynamic therapy of cancer. Reprinted
with permission from Ref. [63] Copyright 2020, MDPI. e The assembly of aptamer-decorated
MOFs nanoparticles for cancer therapy. Reprinted with permission from Ref. [66] Copyright 2019,
MDPI. f ATP aptamer-modified GO for intracellular ATP detection. Reprinted with permission
from Ref. [67] Copyright 2014, American Chemical Society. g GO loaded with drug and modified
with aptamers for chemo-photothermal synergetic cancer therapy. Reprinted with permission from
Ref. [69] Copyright 2020, The Royal Society of Chemistry
became a promising and novel theranostic platform for delivering anticancer drugs
and tracking nanocarriers.
4.4.1.2 Mesoporous Silica Nanoparticles (MSNs)
Mesoporous silica nanoparticles (MSNs) are commonly used carriers in drug delivery
systems, featuring with homogeneous and tunable mesopore diameter, regular pore
structure, stable skeleton structure, easily modified inner and outer surface, and no
obvious physiological toxicity. Besides, MSNs possess remarkable stability and high
drug loading efficiency. MSNs have a large specific surface area and specific pore
volume. It can load various drugs in the channel, which can slow the release of drug
and improve the durability of efficacy [56, 57]. Xie and his co-workers [58] fabricated MSNs loaded with DOX and modified with aptamer for targeting the EpCAM