14 Perspectives of Aptamers for Medical Applications
457
168. Ababneh N, Alshaer W, Allozi O, Mahafzah A, El-Khateeb M, Hillaireau H, Noiray M, Fattal
E, Ismail S (2013) In vitro selection of modified RNA aptamers against CD44 cancer stem
cell marker. Nucl Acid Ther 23(6):401–407. https://doi.org/10.1089/nat.2013.0423
169. Alshaer W, Hillaireau H, Vergnaud J, Ismail S, Fattal E (2015) Functionalizing liposomes with
anti-CD44 aptamer for selective targeting of cancer cells. Bioconjug Chem 26(7):1307–1313.
https://doi.org/10.1021/bc5004313
170. Alshaer W, Hillaireau H, Vergnaud J, Mura S, Deloménie C, Sauvage F, Ismail S, Fattal E
(2018) Aptamer-guided siRNA-loaded nanomedicines for systemic gene silencing in CD-44
expressing murine triple-negative breast cancer model. J Control Release 271:98–106. https://
doi.org/10.1016/j.jconrel.2017.12.022
171. Matsuda N, Lim B, Wang X, Ueno NT (2017) Early clinical development of epidermal growth
factor receptor targeted therapy in breast cancer. Expert Opin Investig Drugs 26(4):463–479.
https://doi.org/10.1080/13543784.2017.1299707
172. Park HS, Jang MH, Kim EJ, Kim HJ, Lee HJ, Kim YJ, Kim JH, Kang E, Kim SW, Kim
IA, Park SY (2014) High EGFR gene copy number predicts poor outcome in triple-negative
breast cancer. Mod Pathol 27(9):1212–1222. https://doi.org/10.1038/modpathol.2013.251
173. Esposito CL, Passaro D, Longobardo I, Condorelli G, Marotta P, Affuso A, de Franciscis V,
Cerchia L (2011) A neutralizing RNA aptamer against EGFR causes selective apoptotic cell
death. PLoS ONE 6(9):e24071. https://doi.org/10.1371/journal.pone.0024071
174. Camorani S, Esposito CL, Rienzo A, Catuogno S, Iaboni M, Condorelli G, de Franciscis V,
Cerchia L (2014) Inhibition of receptor signaling and of glioblastoma-derived tumor growth
by a novel PDGFRβ aptamer. Mol Ther 22(4):828–841. https://doi.org/10.1038/mt.2013.300
175. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer
statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers
in 185 countries. CA Cancer J Clin 68(6):394–424. https://doi.org/10.3322/caac.21492
176. Wang Y, Luo J, Liu J, Sun S, Xiong Y, Ma Y, Yan S, Yang Y, Yin H, Cai X (2019) Labelfree microfluidic paper-based electrochemical aptasensor for ultrasensitive and simultaneous
multiplexed detection of cancer biomarkers. Biosens Bioelectron 136:84–90. https://doi.org/
10.1016/j.bios.2019.04.032
177. Zamay GS, Kolovskaya OS, Zamay TN, Glazyrin YE, Krat AV, Zubkova O, Spivak E, Wehbe
M, Gargaun A, Muharemagic D, Komarova M, Grigorieva V, Savchenko A, Modestov AA,
Berezovski MV, Zamay AS (2015) Aptamers selected to postoperative lung adenocarcinoma
detect circulating tumor cells in human blood. Mol Ther 23(9):1486–1496. https://doi.org/10.
1038/mt.2015.108
178. Zamay GS, Zamay TN, Kolovskii VA, Shabanov AV, Glazyrin YE, Veprintsev DV, Krat
AV, Zamay SS, Kolovskaya OS, Gargaun A, Sokolov AE, Modestov AA, Artyukhov IP,
Chesnokov NV, Petrova MM, Berezovski MV, Zamay AS (2016) Electrochemical aptasensor
for lung cancer-related protein detection in crude blood plasma samples. Sci Rep 6:34350.
https://doi.org/10.1038/srep34350
179. Wang H, Zhang Y, Yang H, Qin M, Ding X, Liu R, Jiang Y (2018) In vivo SELEX of an
inhibitory NSCLC-specific RNA aptamer from PEGylated RNA library. Mol Ther Nucl Acids
10:187–198. https://doi.org/10.1016/j.omtn.2017.12.003
180. Wang H, Qin M, Liu R, Ding X, Chen ISY, Jiang Y (2019) Characterization of a bifunctional
synthetic rna aptamer and a truncated form for ability to inhibit growth of non-small cell lung
cancer. Sci Rep 9(1):18836. https://doi.org/10.1038/s41598-019-55280-x
181. Corapi E, Carrizo G, Compagno D, Laderach D (2018) Endogenous Galectin-1 in T lymphocytes regulates anti-prostate cancer immunity. Front Immunol 9:2190. https://doi.org/10.3389/
fimmu.2018.02190
182. You X, Wang Y, Wu J, Liu Q, Chen D, Tang D, Wang D (2018) Galectin-1 promotes metastasis
in gastric cancer through a Sphingosine-1-Phosphate receptor 1-Dependent mechanism. Cell
Physiol Biochem 51(1):11–30. https://doi.org/10.1159/000495157
183. Tsai YT, Liang CH, Yu JH, Huang KC, Tung CH, Wu JE, Wu YY, Chang CH, Hong TM, Chen
YL (2019) A DNA aptamer targeting Galectin-1 as a novel immunotherapeutic strategy for
lung cancer. Mol Ther Nucl Acids 18:991–998. https://doi.org/10.1016/j.omtn.2019.10.029
457
168. Ababneh N, Alshaer W, Allozi O, Mahafzah A, El-Khateeb M, Hillaireau H, Noiray M, Fattal
E, Ismail S (2013) In vitro selection of modified RNA aptamers against CD44 cancer stem
cell marker. Nucl Acid Ther 23(6):401–407. https://doi.org/10.1089/nat.2013.0423
169. Alshaer W, Hillaireau H, Vergnaud J, Ismail S, Fattal E (2015) Functionalizing liposomes with
anti-CD44 aptamer for selective targeting of cancer cells. Bioconjug Chem 26(7):1307–1313.
https://doi.org/10.1021/bc5004313
170. Alshaer W, Hillaireau H, Vergnaud J, Mura S, Deloménie C, Sauvage F, Ismail S, Fattal E
(2018) Aptamer-guided siRNA-loaded nanomedicines for systemic gene silencing in CD-44
expressing murine triple-negative breast cancer model. J Control Release 271:98–106. https://
doi.org/10.1016/j.jconrel.2017.12.022
171. Matsuda N, Lim B, Wang X, Ueno NT (2017) Early clinical development of epidermal growth
factor receptor targeted therapy in breast cancer. Expert Opin Investig Drugs 26(4):463–479.
https://doi.org/10.1080/13543784.2017.1299707
172. Park HS, Jang MH, Kim EJ, Kim HJ, Lee HJ, Kim YJ, Kim JH, Kang E, Kim SW, Kim
IA, Park SY (2014) High EGFR gene copy number predicts poor outcome in triple-negative
breast cancer. Mod Pathol 27(9):1212–1222. https://doi.org/10.1038/modpathol.2013.251
173. Esposito CL, Passaro D, Longobardo I, Condorelli G, Marotta P, Affuso A, de Franciscis V,
Cerchia L (2011) A neutralizing RNA aptamer against EGFR causes selective apoptotic cell
death. PLoS ONE 6(9):e24071. https://doi.org/10.1371/journal.pone.0024071
174. Camorani S, Esposito CL, Rienzo A, Catuogno S, Iaboni M, Condorelli G, de Franciscis V,
Cerchia L (2014) Inhibition of receptor signaling and of glioblastoma-derived tumor growth
by a novel PDGFRβ aptamer. Mol Ther 22(4):828–841. https://doi.org/10.1038/mt.2013.300
175. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer
statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers
in 185 countries. CA Cancer J Clin 68(6):394–424. https://doi.org/10.3322/caac.21492
176. Wang Y, Luo J, Liu J, Sun S, Xiong Y, Ma Y, Yan S, Yang Y, Yin H, Cai X (2019) Labelfree microfluidic paper-based electrochemical aptasensor for ultrasensitive and simultaneous
multiplexed detection of cancer biomarkers. Biosens Bioelectron 136:84–90. https://doi.org/
10.1016/j.bios.2019.04.032
177. Zamay GS, Kolovskaya OS, Zamay TN, Glazyrin YE, Krat AV, Zubkova O, Spivak E, Wehbe
M, Gargaun A, Muharemagic D, Komarova M, Grigorieva V, Savchenko A, Modestov AA,
Berezovski MV, Zamay AS (2015) Aptamers selected to postoperative lung adenocarcinoma
detect circulating tumor cells in human blood. Mol Ther 23(9):1486–1496. https://doi.org/10.
1038/mt.2015.108
178. Zamay GS, Zamay TN, Kolovskii VA, Shabanov AV, Glazyrin YE, Veprintsev DV, Krat
AV, Zamay SS, Kolovskaya OS, Gargaun A, Sokolov AE, Modestov AA, Artyukhov IP,
Chesnokov NV, Petrova MM, Berezovski MV, Zamay AS (2016) Electrochemical aptasensor
for lung cancer-related protein detection in crude blood plasma samples. Sci Rep 6:34350.
https://doi.org/10.1038/srep34350
179. Wang H, Zhang Y, Yang H, Qin M, Ding X, Liu R, Jiang Y (2018) In vivo SELEX of an
inhibitory NSCLC-specific RNA aptamer from PEGylated RNA library. Mol Ther Nucl Acids
10:187–198. https://doi.org/10.1016/j.omtn.2017.12.003
180. Wang H, Qin M, Liu R, Ding X, Chen ISY, Jiang Y (2019) Characterization of a bifunctional
synthetic rna aptamer and a truncated form for ability to inhibit growth of non-small cell lung
cancer. Sci Rep 9(1):18836. https://doi.org/10.1038/s41598-019-55280-x
181. Corapi E, Carrizo G, Compagno D, Laderach D (2018) Endogenous Galectin-1 in T lymphocytes regulates anti-prostate cancer immunity. Front Immunol 9:2190. https://doi.org/10.3389/
fimmu.2018.02190
182. You X, Wang Y, Wu J, Liu Q, Chen D, Tang D, Wang D (2018) Galectin-1 promotes metastasis
in gastric cancer through a Sphingosine-1-Phosphate receptor 1-Dependent mechanism. Cell
Physiol Biochem 51(1):11–30. https://doi.org/10.1159/000495157
183. Tsai YT, Liang CH, Yu JH, Huang KC, Tung CH, Wu JE, Wu YY, Chang CH, Hong TM, Chen
YL (2019) A DNA aptamer targeting Galectin-1 as a novel immunotherapeutic strategy for
lung cancer. Mol Ther Nucl Acids 18:991–998. https://doi.org/10.1016/j.omtn.2019.10.029