14 Perspectives of Aptamers for Medical Applications
449
29. Singh V, Krishnan S (2018) Electrochemical and surface plasmon insulin assays on clinical
samples. Analyst 143(7):1544–1555. https://doi.org/10.1039/c7an01872j
30. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L,
Motala AA, Ogurtsova K, Shaw JE, Bright D, Williams R (2019) Global and regional diabetes
prevalence estimates for 2019 and projections for 2030 and 2045: results from the International
diabetes federation diabetes atlas, 9(th) edition. Diabet Res Clin Pract 157:107843. https://
doi.org/10.1016/j.diabres.2019.107843
31. Lin HI, Wu CC, Yang CH, Chang KW, Lee GB, Shiesh SC (2015) Selection of aptamers
specific for glycated hemoglobin and total hemoglobin using on-chip SELEX. Lab Chip
15(2):486–494. https://doi.org/10.1039/c4lc01124d
32. Chang KW, Li J, Yang CH, Shiesh SC, Lee GB (2015) An integrated microfluidic system for
measurement of glycated hemoglobin levels by using an aptamer-antibody assay on magnetic
beads. Biosens Bioelectron 68:397–403. https://doi.org/10.1016/j.bios.2015.01.027
33. Ciobanu DM, Bogdan F, P˘ atru¸ t CI, Roman G (2019) Glycated albumin is correlated with
glycated hemoglobin in type 2 diabetes. Med Pharm Rep 92(2):134–138. https://doi.org/10.
15386/mpr-1247
34. Ghosh S, Datta D, Cheema M, Dutta M, Stroscio MA (2017) Aptasensor based optical detection of glycated albumin for diabetes mellitus diagnosis. Nanotechnology 28(43):435505.
https://doi.org/10.1088/1361-6528/aa893a
35. Gerasimov JY, Schaefer CS, Yang W, Grout RL, Lai RY (2013) Development of an electrochemical insulin sensor based on the insulin-linked polymorphic region. Biosens Bioelectron
42:62–68. https://doi.org/10.1016/j.bios.2012.10.046
36. Connor AC, Frederick KA, Morgan EJ, McGown LB (2006) Insulin capture by an
insulin-linked polymorphic region G-quadruplex DNA oligonucleotide. J Am Chem Soc
128(15):4986–4991. https://doi.org/10.1021/ja056097c
37. Yoshida W, Mochizuki E, Takase M, Hasegawa H, Morita Y, Yamazaki H, Sode K, Ikebukuro
K (2009) Selection of DNA aptamers against insulin and construction of an aptameric enzyme
subunit for insulin sensing. Biosens Bioelectron 24(5):1116–1120. https://doi.org/10.1016/j.
bios.2008.06.016
38. Muhammad S, Xu G, Wei F, Cen Y, Younis MR, Xu X, Shi M, Cheng X, Chai Y, Hu Q (2019)
Simultaneous determination of insulin and glucose in human serum based on dual emissive
fluorescent nano-aptasensor of carbon dots and CdTe/CdS/ZnS quantum dots. Sens Actuators
B Chem 292:321–330
39. Tombelli S, Minunni M, Luzi E, Mascini M (2005) Aptamer-based biosensors for the detection
of HIV-1 Tat protein. Bioelectrochemistry 67(2):135–141. https://doi.org/10.1016/j.bioele
chem.2004.04.011
40. Rahim Ruslinda A, Tanabe K, Ibori S, Wang X, Kawarada H (2013) Effects of diamondFET-based RNA aptamer sensing for detection of real sample of HIV-1 Tat protein. Biosens
Bioelectron 40(1):277–282. https://doi.org/10.1016/j.bios.2012.07.048
41. Schlecht U, Gronewold T, Malave A, Tewes M (2007) Detection of receptor-ligand interactions
with an GHz impedance biosensor system. IEEE Sens J 7(12):1680–1684
42. Porichis F, Kaufmann DE (2011) HIV-specific CD4 T cells and immune control of viral
replication. Curr Opin HIV AIDS 6(3):174–180. https://doi.org/10.1097/COH.0b013e328
3454058
43. Davis KA, Lin Y, Abrams B, Jayasena SD (1998) Staining of cell surface human CD4 with
2 -F-pyrimidine-containing RNA aptamers for flow cytometry. Nucl Acids Res 26(17):3915–
3924. https://doi.org/10.1093/nar/26.17.3915
44. Zhou Q, Liu Y, Shin DS, Silangcruz J, Tuleuova N, Revzin A (2012) Aptamer-containing
surfaces for selective capture of CD4 expressing cells. Langmuir 28(34):12544–12549. https://
doi.org/10.1021/la2050338
45. Trausch JJ, Shank-Retzlaff M, Verch T (2017) Development and characterization of an HPV
Type-16 specific modified DNA aptamer for the improvement of potency assays. Anal Chem
89(6):3554–3561. https://doi.org/10.1021/acs.analchem.6b04852
46. Organization WH (2019) Global Tuberculosis Report 2019. World Health Organization,
449
29. Singh V, Krishnan S (2018) Electrochemical and surface plasmon insulin assays on clinical
samples. Analyst 143(7):1544–1555. https://doi.org/10.1039/c7an01872j
30. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L,
Motala AA, Ogurtsova K, Shaw JE, Bright D, Williams R (2019) Global and regional diabetes
prevalence estimates for 2019 and projections for 2030 and 2045: results from the International
diabetes federation diabetes atlas, 9(th) edition. Diabet Res Clin Pract 157:107843. https://
doi.org/10.1016/j.diabres.2019.107843
31. Lin HI, Wu CC, Yang CH, Chang KW, Lee GB, Shiesh SC (2015) Selection of aptamers
specific for glycated hemoglobin and total hemoglobin using on-chip SELEX. Lab Chip
15(2):486–494. https://doi.org/10.1039/c4lc01124d
32. Chang KW, Li J, Yang CH, Shiesh SC, Lee GB (2015) An integrated microfluidic system for
measurement of glycated hemoglobin levels by using an aptamer-antibody assay on magnetic
beads. Biosens Bioelectron 68:397–403. https://doi.org/10.1016/j.bios.2015.01.027
33. Ciobanu DM, Bogdan F, P˘ atru¸ t CI, Roman G (2019) Glycated albumin is correlated with
glycated hemoglobin in type 2 diabetes. Med Pharm Rep 92(2):134–138. https://doi.org/10.
15386/mpr-1247
34. Ghosh S, Datta D, Cheema M, Dutta M, Stroscio MA (2017) Aptasensor based optical detection of glycated albumin for diabetes mellitus diagnosis. Nanotechnology 28(43):435505.
https://doi.org/10.1088/1361-6528/aa893a
35. Gerasimov JY, Schaefer CS, Yang W, Grout RL, Lai RY (2013) Development of an electrochemical insulin sensor based on the insulin-linked polymorphic region. Biosens Bioelectron
42:62–68. https://doi.org/10.1016/j.bios.2012.10.046
36. Connor AC, Frederick KA, Morgan EJ, McGown LB (2006) Insulin capture by an
insulin-linked polymorphic region G-quadruplex DNA oligonucleotide. J Am Chem Soc
128(15):4986–4991. https://doi.org/10.1021/ja056097c
37. Yoshida W, Mochizuki E, Takase M, Hasegawa H, Morita Y, Yamazaki H, Sode K, Ikebukuro
K (2009) Selection of DNA aptamers against insulin and construction of an aptameric enzyme
subunit for insulin sensing. Biosens Bioelectron 24(5):1116–1120. https://doi.org/10.1016/j.
bios.2008.06.016
38. Muhammad S, Xu G, Wei F, Cen Y, Younis MR, Xu X, Shi M, Cheng X, Chai Y, Hu Q (2019)
Simultaneous determination of insulin and glucose in human serum based on dual emissive
fluorescent nano-aptasensor of carbon dots and CdTe/CdS/ZnS quantum dots. Sens Actuators
B Chem 292:321–330
39. Tombelli S, Minunni M, Luzi E, Mascini M (2005) Aptamer-based biosensors for the detection
of HIV-1 Tat protein. Bioelectrochemistry 67(2):135–141. https://doi.org/10.1016/j.bioele
chem.2004.04.011
40. Rahim Ruslinda A, Tanabe K, Ibori S, Wang X, Kawarada H (2013) Effects of diamondFET-based RNA aptamer sensing for detection of real sample of HIV-1 Tat protein. Biosens
Bioelectron 40(1):277–282. https://doi.org/10.1016/j.bios.2012.07.048
41. Schlecht U, Gronewold T, Malave A, Tewes M (2007) Detection of receptor-ligand interactions
with an GHz impedance biosensor system. IEEE Sens J 7(12):1680–1684
42. Porichis F, Kaufmann DE (2011) HIV-specific CD4 T cells and immune control of viral
replication. Curr Opin HIV AIDS 6(3):174–180. https://doi.org/10.1097/COH.0b013e328
3454058
43. Davis KA, Lin Y, Abrams B, Jayasena SD (1998) Staining of cell surface human CD4 with
2 -F-pyrimidine-containing RNA aptamers for flow cytometry. Nucl Acids Res 26(17):3915–
3924. https://doi.org/10.1093/nar/26.17.3915
44. Zhou Q, Liu Y, Shin DS, Silangcruz J, Tuleuova N, Revzin A (2012) Aptamer-containing
surfaces for selective capture of CD4 expressing cells. Langmuir 28(34):12544–12549. https://
doi.org/10.1021/la2050338
45. Trausch JJ, Shank-Retzlaff M, Verch T (2017) Development and characterization of an HPV
Type-16 specific modified DNA aptamer for the improvement of potency assays. Anal Chem
89(6):3554–3561. https://doi.org/10.1021/acs.analchem.6b04852
46. Organization WH (2019) Global Tuberculosis Report 2019. World Health Organization,