426
H. Jin
Table 14.3
Aptamer in cardiovascular disease
Biomarker
Aptamer-sequence 5
→ 3
Kd
cTnI
5‘-CGT GCA GTA CGC CAA CCT TTC TCA TGC GCT GCC CCT CTT A-3
270 pM
5
-GCC TGT TGT GAG CCT CCT AAC TAC ATG TTC TCA GGG TTG
AGG CTG GAT GGC GAT GGT GGC ATG CTT ATT CTT GTC TCC C-3
9.009
± 2.437 nM
5
-(SH)-(CH2)6- AGTCTCCGCTGTCCTCCCGATGCACTTGACGTATGTCTC
ACTTTCTTTTCATTGACATGGGATGACGCCGTGACTG-3
N/A
cTnT
5
-CGT AGA ATT CAT GAG GAC GTT ACG TAC CGA CTT CGT ATG CCA ACA
GCC CTT TAT CCA CCT CAG CTA AGC TTA CCA GTG CGA T-3
43.8
± 13.7 nM
BNP
5
-GGC GAT TCG TGA TCT CTG CTC TCG GTT TCG CGT TCG TTC G-3
12 nM
5
-ATA CGG GAG CCA ACA CCA CGT TGC GCA GCT GGG GGC AGT GCT CTT TCG ATT TGG AGA GCA
GGT GTG ACG GAT-3
N/A
5
-TAA ACG CTC AAA GGA CAG AGG GTG CGT AGG AAG GGT ATT CGA CAG GAG GCT CAC A-3
N/A
NT-proBNP 5
-CAC CTA ATA CGA CTC ACT ATA GCG GAT CCG ATA GGG TTG TAC TTT CGA TAG CCA GGG CTT GGG
GTG GTT GGC TGG CTC GAA CAA GCT TGC-3
55 nM
Myoglobin 5
-GAC AGG CAG GAC ACC GTA ACC CC TCC TTT CCT TCG ACG TAG ATC TGC TGC GTT GTT CCG ACT
GCT ACC TCC CTC CTC TTC-3
4.93 nM
CK-MB
5
-GGG GGG TGG GTG GGG GAT CTC GGA GGA TGC TTT TAG GGG GTT GG-3
0.81
± 0.79 nM
5
-CAC CTA ATA CGA CTC ACT ATA GCG GAT CCG AAA GTC GGA GCA GAA GTT GCC TCA TAG CTG GGA
AAC CTG CCC TGG CTC GAA CAA GCT TGC-3
43 mM
CRP
5
-CGA AGG GGA TTC GAG GGG TGA TTG CGT GCT CCA TTT GGT G-3
16.2 nM