408
H. Jin
Table 14.1
(continued)
Characters
Merits
Demerits
Merits
Demerits
Interaction Flexibility 1. Renature easily after
denaturation
2. Pharmacokinetic parameters
can be changed on demand
3. Produced in a controlled
manner
4. No affinity loss after
modification of aptamers
N/A
N/A
1. Cannot renature after
denaturation
2. Cannot change
pharmacokinetic
parameters on demand
3. Produced in an
uncontrolled manner
Safety related
Nature structure has no
immunogenicity and toxicity
N/A
N/A
May have immunogenicity or
toxicity
Molecular Size
1. Small
2. High tissue penetration
capacity
Rapidly excreted by the
kidneys
N/A
1. Large
2. A limited tissue
penetration capacity
Specificity
Single point mutation
identifiable
Cross reactive with its
analogues
N/A
Different antibody might bind
same antigen