1 Introduction of Aptamer, SELEX, and Different SELEX Variants
27
14. Li Q, Zhao X, Liu H, Qu F (2014) Low pH capillary electrophoresis application to improve capillary electrophoresis-systematic evolution of ligands by exponential enrichment. J Chromatogr
A 1364:289–294
15. Zhu C, Wang X, Li L, Hao C, Hu Y, Rizvi AS, Qu F (2018) Online reaction based single-step
CE for Protein-ssDNA complex obtainment to assist aptamer selection. Biochem Biophys Res
Commun 506:169–175
16. Bruno JG (1997) In vitro selection of DNA to chloroaromatics using magnetic microbead-based
affinity separation and fluorescence detection. Biochem Biophys Res Commun 234:117–120
17. Ruscito A, DeRosa MC (2016) Small-molecule binding aptamers: selection strategies,
characterization, and applications. Front Chemis 4
18. Pfeiffer F, Mayer G (2016) Selection and biosensor application of aptamers for small molecules.
Front Chemis 4
19. Stoltenburg R, Reinemann C, Strehlitz B (2005) FluMag-SELEX as an advantageous method
for DNA aptamer selection. Anal Bioanal Chem 383:83–91
20. Kim YS, Hyun CJ, Kim IA, Gu MB (2010) Isolation and characterization of enantioselective
DNA aptamers for ibuprofen. Bioorg Med Chem 18:3467–3473
21. Xu S, Yuan H, Chen S, Xu A, Wang J, Wu L (2012) Selection of DNA aptamers against
polychlorinated biphenyls as potential biorecognition elements for environmental analysis.
Anal Biochem 423:195–201
22. Eissa S, Zourob M (2017) In vitro selection of DNA aptamers targeting beta-lactoglobulin
and their integration in graphene-based biosensor for the detection of milk allergen. Biosens
Bioelectron 91:169–174
23. Ruscito A, DeRosa MC (2016) Small-molecule binding aptamers: selection strategies,
characterization, and applications. Front Chemis 4:14
24. Qian J, Lou X, Zhang Y, Xiao Y, Soh HT (2009) Generation of highly specific aptamers via
micromagnetic selection. Anal Chem 81:5490–5495
25. Lou XH, Qian JR, Xiao Y, Viel L, Gerdon AE, Lagally ET, Atzberger P, Tarasow TM, Heeger
AJ, Soh HT (2009) Micromagnetic selection of aptamers in microfluidic channels. Proc Nat
Acad Sci USA 106:2989–2994
26. Weng CH, Huang CJ, Lee GB (2012) Screening of aptamers on microfluidic systems for clinical
applications. Sensors 12:9514–9529
27. Sinha A, Gopinathan P, Chung YD, Lin HY, Li KH, Ma HP, Huang PC, Shiesh SC, Lee GB
(2018) An integrated microfluidic platform to perform uninterrupted SELEX cycles to screen
affinity reagents specific to cardiovascular biomarkers. Biosens Bioelectron 122:104–112
28. Nutiu R, Li Y (2005) In vitro selection of structure-switching signaling aptamers. Angew Chem
Int Ed Engl 44:1061–1065
29. Stoltenburg R, Nikolaus N, Strehlitz B (2012) Capture-SELEX: selection of DNA aptamers
for aminoglycoside antibiotics. J Anal Methods Chem 2012:415697
30. Oh SS, Plakos K, Lou X, Xiao Y, Soh HT (2010) In vitro selection of structure-switching,
self-reporting aptamers. Proc Natl Acad Sci USA 107:14053–14058
31. Yang KA, Barbu M, Halim M, Pallavi P, Kim B, Kolpashchikov DM, Pecic S, Taylor S,
Worgall TS, Stojanovic MN (2014) Recognition and sensing of low-epitope targets via ternary
complexes with oligonucleotides and synthetic receptors. Nat Chem 6:1003–1008
32. Ye H, Duan N, Wu S, Tan G, Gu H, Li J, Wang H, Wang Z (2017) Orientation selection
of broad-spectrum aptamers against lipopolysaccharides based on capture-SELEX by using
magnetic nanoparticles. Microchim Acta 184:4235–4242
33. Wu Y, Zhan S, Wang L, Zhou P (2014) Selection of a DNA aptamer for cadmium detection
based on cationic polymer mediated aggregation of gold nanoparticles. Analyst 139:1550–1561
34. Spiga FM, Maietta P, Guiducci C (2015) More DNA-aptamers for small drugs: a captureSELEX Coupled with surface plasmon resonance and high-throughput sequencing. ACS Comb
Sci 17:326–333
35. Paniel N, Istamboulie G, Triki A, Lozano C, Barthelmebs L, Noguer T (2017) Selection of DNA
aptamers against penicillin G using Capture-SELEX for the development of an impedimetric
sensor. Talanta 162:232–240
27
14. Li Q, Zhao X, Liu H, Qu F (2014) Low pH capillary electrophoresis application to improve capillary electrophoresis-systematic evolution of ligands by exponential enrichment. J Chromatogr
A 1364:289–294
15. Zhu C, Wang X, Li L, Hao C, Hu Y, Rizvi AS, Qu F (2018) Online reaction based single-step
CE for Protein-ssDNA complex obtainment to assist aptamer selection. Biochem Biophys Res
Commun 506:169–175
16. Bruno JG (1997) In vitro selection of DNA to chloroaromatics using magnetic microbead-based
affinity separation and fluorescence detection. Biochem Biophys Res Commun 234:117–120
17. Ruscito A, DeRosa MC (2016) Small-molecule binding aptamers: selection strategies,
characterization, and applications. Front Chemis 4
18. Pfeiffer F, Mayer G (2016) Selection and biosensor application of aptamers for small molecules.
Front Chemis 4
19. Stoltenburg R, Reinemann C, Strehlitz B (2005) FluMag-SELEX as an advantageous method
for DNA aptamer selection. Anal Bioanal Chem 383:83–91
20. Kim YS, Hyun CJ, Kim IA, Gu MB (2010) Isolation and characterization of enantioselective
DNA aptamers for ibuprofen. Bioorg Med Chem 18:3467–3473
21. Xu S, Yuan H, Chen S, Xu A, Wang J, Wu L (2012) Selection of DNA aptamers against
polychlorinated biphenyls as potential biorecognition elements for environmental analysis.
Anal Biochem 423:195–201
22. Eissa S, Zourob M (2017) In vitro selection of DNA aptamers targeting beta-lactoglobulin
and their integration in graphene-based biosensor for the detection of milk allergen. Biosens
Bioelectron 91:169–174
23. Ruscito A, DeRosa MC (2016) Small-molecule binding aptamers: selection strategies,
characterization, and applications. Front Chemis 4:14
24. Qian J, Lou X, Zhang Y, Xiao Y, Soh HT (2009) Generation of highly specific aptamers via
micromagnetic selection. Anal Chem 81:5490–5495
25. Lou XH, Qian JR, Xiao Y, Viel L, Gerdon AE, Lagally ET, Atzberger P, Tarasow TM, Heeger
AJ, Soh HT (2009) Micromagnetic selection of aptamers in microfluidic channels. Proc Nat
Acad Sci USA 106:2989–2994
26. Weng CH, Huang CJ, Lee GB (2012) Screening of aptamers on microfluidic systems for clinical
applications. Sensors 12:9514–9529
27. Sinha A, Gopinathan P, Chung YD, Lin HY, Li KH, Ma HP, Huang PC, Shiesh SC, Lee GB
(2018) An integrated microfluidic platform to perform uninterrupted SELEX cycles to screen
affinity reagents specific to cardiovascular biomarkers. Biosens Bioelectron 122:104–112
28. Nutiu R, Li Y (2005) In vitro selection of structure-switching signaling aptamers. Angew Chem
Int Ed Engl 44:1061–1065
29. Stoltenburg R, Nikolaus N, Strehlitz B (2012) Capture-SELEX: selection of DNA aptamers
for aminoglycoside antibiotics. J Anal Methods Chem 2012:415697
30. Oh SS, Plakos K, Lou X, Xiao Y, Soh HT (2010) In vitro selection of structure-switching,
self-reporting aptamers. Proc Natl Acad Sci USA 107:14053–14058
31. Yang KA, Barbu M, Halim M, Pallavi P, Kim B, Kolpashchikov DM, Pecic S, Taylor S,
Worgall TS, Stojanovic MN (2014) Recognition and sensing of low-epitope targets via ternary
complexes with oligonucleotides and synthetic receptors. Nat Chem 6:1003–1008
32. Ye H, Duan N, Wu S, Tan G, Gu H, Li J, Wang H, Wang Z (2017) Orientation selection
of broad-spectrum aptamers against lipopolysaccharides based on capture-SELEX by using
magnetic nanoparticles. Microchim Acta 184:4235–4242
33. Wu Y, Zhan S, Wang L, Zhou P (2014) Selection of a DNA aptamer for cadmium detection
based on cationic polymer mediated aggregation of gold nanoparticles. Analyst 139:1550–1561
34. Spiga FM, Maietta P, Guiducci C (2015) More DNA-aptamers for small drugs: a captureSELEX Coupled with surface plasmon resonance and high-throughput sequencing. ACS Comb
Sci 17:326–333
35. Paniel N, Istamboulie G, Triki A, Lozano C, Barthelmebs L, Noguer T (2017) Selection of DNA
aptamers against penicillin G using Capture-SELEX for the development of an impedimetric
sensor. Talanta 162:232–240