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69. Shen Z, Wu A, Chen X (2017) Current detection technologies for circulating tumor cells.
Chem Soc Rev 46(8):2038–2056
70. Green BJ, Saberi Safaei T, Mepham A, Labib M, Mohamadi RM, Kelley SO (2016) Beyond
the capture of circulating tumor cells: next-generation devices and materials. Angew Chem
Int Ed Engl 55(4):1252–1265
71. Sieuwerts AM, Kraan J, Bolt J, van der Spoel P, Elstrodt F, Schutte M, Martens JWM, Gratama
J-W, Sleijfer S, Foekens JA (2009) Anti-epithelial cell adhesion molecule antibodies and the
detection of circulating normal-like breast tumor cells. J Natl Cancer I 101(1):61–66
72. Zhao W, Cui CH, Bose S, Guo D, Shen C, Wong WP, Halvorsen K, Farokhzad OC, Teo GSL,
Phillips JA (2012) Bioinspired multivalent DNA network for capture and release of cells. Proc
Natl Acad Sci USA 109(48):19626–19631
73. Shen Q, Xu L, Zhao L, Wu D, Fan Y, Zhou Y, OuYang WH, Xu X, Zhang Z, Song M (2013)
Specific capture and release of circulating tumor cells using aptamer-modified nanosubstrates.
Adv Mater 25(16):2368–2373
74. Wan Y, Liu Y, Allen PB, Asghar W, Mahmood MAI, Tan J, Duhon H, Kim Y-t, Ellington AD,
Iqbal SM (2012) Capture, isolation and release of cancer cells with aptamer-functionalized
glass bead array. Lab Chip 12(22):4693–4701
75. Hasanzadeh M, Shadjou N, de la Guardia M (2015) Recent advances in nanostructures and
nanocrystals as signal-amplification elements in electrochemical cytosensing. TrAC Trends
Anal Chem 72:123–140
76. Li S, Liu Y, Ma Q (2019) Nanoparticle-based electrochemiluminescence cytosensors for
single cell level detection. TrAC Trends Anal Chem 110:277–292
77. Lorenzo-Gómez R, Miranda-Castro R, de-los-Santos-Álvarez N, Lobo-Castañón MJ (2019)
Electrochemical aptamer-based assays coupled to isothermal nucleic acid amplification
techniques: New tools for cancer diagnosis. Curr Opin Electrochem 14:32-43
78. Du Y, Dong S (2017) Nucleic acid biosensors: recent advances and perspectives. Anal Chem
89(1):189–215
79. Zhao Y, Xu D, Tan W (2017) Aptamer-functionalized nano/micro-materials for clinical
diagnosis: isolation, release and bioanalysis of circulating tumor cells. Integr Biol-UK
9(3):188–205
80. Pan C, Guo M, Nie Z, Xiao X, Yao S (2009) Aptamer-based electrochemical sensor for
label-free recognition and detection of cancer cells. Electroanalysis 21(11):1321–1326
81. Feng L, Chen Y, Ren J, Qu X (2011) A graphene functionalized electrochemical aptasensor
for selective label-free detection of cancer cells. Biomaterials 32(11):2930–2937
82. Zhang H, Li B, Sun Z, Zhou H, Zhang S (2017) Integration of intracellular telomerase
monitoring by electrochemiluminescence technology and targeted cancer therapy by reactive
oxygen species. Chem Sci 8(12):8025–8029
83. Liu S, Zhao S, Tu W, Wang X, Wang X, Bao J, Wang Y, Han M, Dai Z (2018) A “signal
on” photoelectrochemical biosensor based on bismuth@ N, O-codoped-carbon core-shell
nanohybrids for ultrasensitive detection of telomerase in HeLa cells. Chem Eur J 24(15):3677–
3682
84. Khoshfetrat SM, Mehrgardi MA (2017) Amplified detection of leukemia cancer cells using
an aptamer-conjugated gold-coated magnetic nanoparticles on a nitrogen-doped graphene
modified electrode. Bioelectrochemistry 114:24–32
85. Cao J, Zhao X-P, Younis MR, Li Z-Q, Xia X-H, Wang C (2017) Ultrasensitive capture,
detection, and release of circulating tumor cells using a nanochannel–ion channel hybrid
coupled with electrochemical detection technique. Anal Chem 89(20):10957–10964
86. Sun D, Lu J, Zhang L, Chen Z (2019) Aptamer-based electrochemical cytosensors for tumor
cell detection in cancer diagnosis: A review. Anal Chim Acta 1082:1–17
87. Li J, Lin X, Zhang Z, Tu W, Dai Z (2019) Red light-driven photoelectrochemical biosensing for
ultrasensitive and scatheless assay of tumor cells based on hypotoxic AgInS2 nanoparticles.
Biosens Bioelectron 126:332–338
Q. Lv et al.
68. Chaffer CL, Weinberg RA (2011) A perspective on cancer cell metastasis. Science
331(6024):1559–1564
69. Shen Z, Wu A, Chen X (2017) Current detection technologies for circulating tumor cells.
Chem Soc Rev 46(8):2038–2056
70. Green BJ, Saberi Safaei T, Mepham A, Labib M, Mohamadi RM, Kelley SO (2016) Beyond
the capture of circulating tumor cells: next-generation devices and materials. Angew Chem
Int Ed Engl 55(4):1252–1265
71. Sieuwerts AM, Kraan J, Bolt J, van der Spoel P, Elstrodt F, Schutte M, Martens JWM, Gratama
J-W, Sleijfer S, Foekens JA (2009) Anti-epithelial cell adhesion molecule antibodies and the
detection of circulating normal-like breast tumor cells. J Natl Cancer I 101(1):61–66
72. Zhao W, Cui CH, Bose S, Guo D, Shen C, Wong WP, Halvorsen K, Farokhzad OC, Teo GSL,
Phillips JA (2012) Bioinspired multivalent DNA network for capture and release of cells. Proc
Natl Acad Sci USA 109(48):19626–19631
73. Shen Q, Xu L, Zhao L, Wu D, Fan Y, Zhou Y, OuYang WH, Xu X, Zhang Z, Song M (2013)
Specific capture and release of circulating tumor cells using aptamer-modified nanosubstrates.
Adv Mater 25(16):2368–2373
74. Wan Y, Liu Y, Allen PB, Asghar W, Mahmood MAI, Tan J, Duhon H, Kim Y-t, Ellington AD,
Iqbal SM (2012) Capture, isolation and release of cancer cells with aptamer-functionalized
glass bead array. Lab Chip 12(22):4693–4701
75. Hasanzadeh M, Shadjou N, de la Guardia M (2015) Recent advances in nanostructures and
nanocrystals as signal-amplification elements in electrochemical cytosensing. TrAC Trends
Anal Chem 72:123–140
76. Li S, Liu Y, Ma Q (2019) Nanoparticle-based electrochemiluminescence cytosensors for
single cell level detection. TrAC Trends Anal Chem 110:277–292
77. Lorenzo-Gómez R, Miranda-Castro R, de-los-Santos-Álvarez N, Lobo-Castañón MJ (2019)
Electrochemical aptamer-based assays coupled to isothermal nucleic acid amplification
techniques: New tools for cancer diagnosis. Curr Opin Electrochem 14:32-43
78. Du Y, Dong S (2017) Nucleic acid biosensors: recent advances and perspectives. Anal Chem
89(1):189–215
79. Zhao Y, Xu D, Tan W (2017) Aptamer-functionalized nano/micro-materials for clinical
diagnosis: isolation, release and bioanalysis of circulating tumor cells. Integr Biol-UK
9(3):188–205
80. Pan C, Guo M, Nie Z, Xiao X, Yao S (2009) Aptamer-based electrochemical sensor for
label-free recognition and detection of cancer cells. Electroanalysis 21(11):1321–1326
81. Feng L, Chen Y, Ren J, Qu X (2011) A graphene functionalized electrochemical aptasensor
for selective label-free detection of cancer cells. Biomaterials 32(11):2930–2937
82. Zhang H, Li B, Sun Z, Zhou H, Zhang S (2017) Integration of intracellular telomerase
monitoring by electrochemiluminescence technology and targeted cancer therapy by reactive
oxygen species. Chem Sci 8(12):8025–8029
83. Liu S, Zhao S, Tu W, Wang X, Wang X, Bao J, Wang Y, Han M, Dai Z (2018) A “signal
on” photoelectrochemical biosensor based on bismuth@ N, O-codoped-carbon core-shell
nanohybrids for ultrasensitive detection of telomerase in HeLa cells. Chem Eur J 24(15):3677–
3682
84. Khoshfetrat SM, Mehrgardi MA (2017) Amplified detection of leukemia cancer cells using
an aptamer-conjugated gold-coated magnetic nanoparticles on a nitrogen-doped graphene
modified electrode. Bioelectrochemistry 114:24–32
85. Cao J, Zhao X-P, Younis MR, Li Z-Q, Xia X-H, Wang C (2017) Ultrasensitive capture,
detection, and release of circulating tumor cells using a nanochannel–ion channel hybrid
coupled with electrochemical detection technique. Anal Chem 89(20):10957–10964
86. Sun D, Lu J, Zhang L, Chen Z (2019) Aptamer-based electrochemical cytosensors for tumor
cell detection in cancer diagnosis: A review. Anal Chim Acta 1082:1–17
87. Li J, Lin X, Zhang Z, Tu W, Dai Z (2019) Red light-driven photoelectrochemical biosensing for
ultrasensitive and scatheless assay of tumor cells based on hypotoxic AgInS2 nanoparticles.
Biosens Bioelectron 126:332–338