170
G. Yang and Y. Huang
inhibits development of collagen-induced arthritis in cynomolgus monkeys. Nucleic Acid
Ther 26(1):10–19
104. Meyer C, Berg K, Eydeler-Haeder K, Lorenzen I, Grotzinger J, Rose-John S, Hahn U (2014)
Stabilized interleukin-6 receptor binding RNA aptamers. RNA Biol 11(1):57–65
105. Szameit K, Berg K, Kruspe S, Valentini E, Magbanua E, Kwiatkowski M, Chauvot de
Beauchene I, Krichel B, Schamoni K, Uetrecht C, Svergun DI, Schluter H, Zacharias M,
Hahn U (2016) Structure and target interaction of a G-quadruplex RNA-aptamer. RNA Biol
13(10):973–987
106. Hahn U (2017) Charomers-Interleukin-6 receptor specific aptamers for cellular internalization
and targeted drug delivery. Int J Mol Sci 18(12):2641
107. Prisner L, Bohn N, Hahn U, Mews A (2017) Size dependent targeted delivery of gold nanoparticles modified with the IL-6R-specific aptamer AIR-3A to IL-6R-carrying cells. Nanoscale
9(38):14486–14498
108. Thelen M (2001) Dancing to the tune of chemokines. Nat Immunol 2(2):129–134
109. Baggiolini M, Walz A, Kunkel SL (1989) Neutrophil-activating peptide-1 interleukin-8, a
novel cytokine that activates neutrophils. J Clin Invest 84(4):1045–1049
110. Waugh DJ, Wilson C (2008) The interleukin-8 pathway in cancer. Clin Cancer Res
14(21):6735–6741
111. Skov L, Beurskens FJ, Zachariae COC, Reitamo S, Teeling J, Satijn D, Knudsen KM, Boot
EPJ, Hudson D, Baadsgaard O, Parren PWHI, de Winkel JGJV (2008) IL-8 as antibody
therapeutic target in inflammatory diseases: Reduction of clinical activity in palmoplantar
pustulosis. J Immunol 181(1):669–679
112. Sung HJ, Choi S, Lee JW, Ok CY, Bae YS, Kim YH, Lee W, Heo K, Kim IH (2014) Inhibition of human neutrophil activity by an RNA aptamer bound to interleukin-8. Biomaterials
35(1):578–589
113. Blackburn SD, Wherry EJ (2007) IL-10, T cell exhaustion and viral persistence. Trends
Microbiol 15(4):143–146
114. Couper KN, Blount DG, Riley EM (2008) IL-10: the master regulator of immunity to infection.
J Immunol 180(9):5771–5777
115. Moore KW, de Waal Malefyt R, Coffman RL, O’Garra A (2001) Interleukin-10 and the
interleukin-10 receptor. Annu Rev Immunol 19 (0732–0582 Print):683–765
116. Brooks DG, Trifilo MJ, Edelmann KH, Teyton L, McGavern DB, Oldstone MB (2006)
Interleukin-10 determines viral clearance or persistence in vivo. Nat Med 12(11):1301–1309
117. Brockman MA, Kwon DS, Tighe DP, Pavlik DF, Rosato PC, Sela J, Porichis F, Le Gall S,
Waring MT, Moss K, Jessen H, Pereyra F, Kavanagh DG, Walker BD, Kaufmann DE (2009)
IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly
inhibits virus-specific T cells. Blood 114(2):346–356
118. Berezhnoy A, Stewart CA, Mcnamara JO, Thiel W, Giangrande P, Trinchieri G, Gilboa E
(2012) Isolation and optimization of murine IL-10 receptor blocking oligonucleotide aptamers
using high-throughput sequencing. Mol Ther 20(6):1242–1250
119. Tang W, Geba GP, Zheng T, Ray P, Homer RJ, Kuhn C 3rd, Flavell RA, Elias JA (1996)
Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation,
bronchial remodeling, and airways obstruction. J Clin Invest 98(12):2845–2853
120. Nguyen PM, Abdirahman SM, Putoczki TL (2019) Emerging roles for Interleukin-11 in
disease. Growth Factors 37(1–2):1–11
121. Lokau J, Agthe M, Flynn CM, Garbers C (2017) Proteolytic control of Interleukin-11 and
Interleukin-6 biology. Biochim Biophys Acta Mol Cell Res 1864 (11 Pt B):2105–2117
122. Arap W, Kolonin MG, Trepel M, Lahdenranta J, Cardo-Vila M, Giordano RJ, Mintz PJ, Ardelt
PU, Yao VJ, Vidal CI, Chen L, Flamm A, Valtanen H, Weavind LM, Hicks ME, Pollock RE,
Botz GH, Bucana CD, Koivunen E, Cahill D, Troncoso P, Baggerly KA, Pentz RD, Do KA,
Logothetis CJ, Pasqualini R (2002) Steps toward mapping the human vasculature by phage
display. Nat Med 8(2):121–127
123. Krueger GG, Langley RG, Leonardi C, Yeilding N, Guzzo C, Wang Y, Dooley LT, Lebwohl
M, Group CPS (2007) A human interleukin-12/23 monoclonal antibody for the treatment of
psoriasis. N Engl J Med 356(6):580–592
G. Yang and Y. Huang
inhibits development of collagen-induced arthritis in cynomolgus monkeys. Nucleic Acid
Ther 26(1):10–19
104. Meyer C, Berg K, Eydeler-Haeder K, Lorenzen I, Grotzinger J, Rose-John S, Hahn U (2014)
Stabilized interleukin-6 receptor binding RNA aptamers. RNA Biol 11(1):57–65
105. Szameit K, Berg K, Kruspe S, Valentini E, Magbanua E, Kwiatkowski M, Chauvot de
Beauchene I, Krichel B, Schamoni K, Uetrecht C, Svergun DI, Schluter H, Zacharias M,
Hahn U (2016) Structure and target interaction of a G-quadruplex RNA-aptamer. RNA Biol
13(10):973–987
106. Hahn U (2017) Charomers-Interleukin-6 receptor specific aptamers for cellular internalization
and targeted drug delivery. Int J Mol Sci 18(12):2641
107. Prisner L, Bohn N, Hahn U, Mews A (2017) Size dependent targeted delivery of gold nanoparticles modified with the IL-6R-specific aptamer AIR-3A to IL-6R-carrying cells. Nanoscale
9(38):14486–14498
108. Thelen M (2001) Dancing to the tune of chemokines. Nat Immunol 2(2):129–134
109. Baggiolini M, Walz A, Kunkel SL (1989) Neutrophil-activating peptide-1 interleukin-8, a
novel cytokine that activates neutrophils. J Clin Invest 84(4):1045–1049
110. Waugh DJ, Wilson C (2008) The interleukin-8 pathway in cancer. Clin Cancer Res
14(21):6735–6741
111. Skov L, Beurskens FJ, Zachariae COC, Reitamo S, Teeling J, Satijn D, Knudsen KM, Boot
EPJ, Hudson D, Baadsgaard O, Parren PWHI, de Winkel JGJV (2008) IL-8 as antibody
therapeutic target in inflammatory diseases: Reduction of clinical activity in palmoplantar
pustulosis. J Immunol 181(1):669–679
112. Sung HJ, Choi S, Lee JW, Ok CY, Bae YS, Kim YH, Lee W, Heo K, Kim IH (2014) Inhibition of human neutrophil activity by an RNA aptamer bound to interleukin-8. Biomaterials
35(1):578–589
113. Blackburn SD, Wherry EJ (2007) IL-10, T cell exhaustion and viral persistence. Trends
Microbiol 15(4):143–146
114. Couper KN, Blount DG, Riley EM (2008) IL-10: the master regulator of immunity to infection.
J Immunol 180(9):5771–5777
115. Moore KW, de Waal Malefyt R, Coffman RL, O’Garra A (2001) Interleukin-10 and the
interleukin-10 receptor. Annu Rev Immunol 19 (0732–0582 Print):683–765
116. Brooks DG, Trifilo MJ, Edelmann KH, Teyton L, McGavern DB, Oldstone MB (2006)
Interleukin-10 determines viral clearance or persistence in vivo. Nat Med 12(11):1301–1309
117. Brockman MA, Kwon DS, Tighe DP, Pavlik DF, Rosato PC, Sela J, Porichis F, Le Gall S,
Waring MT, Moss K, Jessen H, Pereyra F, Kavanagh DG, Walker BD, Kaufmann DE (2009)
IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly
inhibits virus-specific T cells. Blood 114(2):346–356
118. Berezhnoy A, Stewart CA, Mcnamara JO, Thiel W, Giangrande P, Trinchieri G, Gilboa E
(2012) Isolation and optimization of murine IL-10 receptor blocking oligonucleotide aptamers
using high-throughput sequencing. Mol Ther 20(6):1242–1250
119. Tang W, Geba GP, Zheng T, Ray P, Homer RJ, Kuhn C 3rd, Flavell RA, Elias JA (1996)
Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation,
bronchial remodeling, and airways obstruction. J Clin Invest 98(12):2845–2853
120. Nguyen PM, Abdirahman SM, Putoczki TL (2019) Emerging roles for Interleukin-11 in
disease. Growth Factors 37(1–2):1–11
121. Lokau J, Agthe M, Flynn CM, Garbers C (2017) Proteolytic control of Interleukin-11 and
Interleukin-6 biology. Biochim Biophys Acta Mol Cell Res 1864 (11 Pt B):2105–2117
122. Arap W, Kolonin MG, Trepel M, Lahdenranta J, Cardo-Vila M, Giordano RJ, Mintz PJ, Ardelt
PU, Yao VJ, Vidal CI, Chen L, Flamm A, Valtanen H, Weavind LM, Hicks ME, Pollock RE,
Botz GH, Bucana CD, Koivunen E, Cahill D, Troncoso P, Baggerly KA, Pentz RD, Do KA,
Logothetis CJ, Pasqualini R (2002) Steps toward mapping the human vasculature by phage
display. Nat Med 8(2):121–127
123. Krueger GG, Langley RG, Leonardi C, Yeilding N, Guzzo C, Wang Y, Dooley LT, Lebwohl
M, Group CPS (2007) A human interleukin-12/23 monoclonal antibody for the treatment of
psoriasis. N Engl J Med 356(6):580–592