6 Aptamers for Targeted Therapy
135
Table 6.2
Representative aptamers targeting the molecules involved in coagulation [39]
Aptamer
Target
Length
Nucleotide
Sequence (5
−3
)
ARC-183/HD1
Thrombin
Exosite I
15 nt
DNA
GGTTGGTGTGGTTGG
HD22
Thrombin
Exosite II
29 nt
DNA
AGTCCGTGGTAGGGCAGGTTGGGGTGACT
HD1-22
Thrombin
Exosite I/II
59 nt
DNA
GGTTGGTGTGGTTGGAAAAAAAAAAAAAAAAGTCCGTGGTAGGGCAGGTTGGGGTGACT
NU172
Thrombin
Exosite I
26 nt
DNA
CGCCTAGGTTGGGTAGGGTGGTGGCG
TOG25
Thrombin
Exosite II
25 nt
RNA
GGGAACAAAGCUGAAGUACUUACCC
RB006
FIXa
30 nt
RNA
GUGGACUAUACCGCGUAAUGCUGCCUCCAC
RB007
RB006
15 nt
RNA
CGCGGUAUAGUCCAC
9.14
von
Willebrand
factor
80 nt
DNA
GGGAGGACGATGCGGTGGACGAACTGCCCTCAGCTACTTTCATGTTGCTGACGCACAGACGACTCGCTGAGGATCCGAGA
ARC19499/BAX
499
Tissue factor
pathway
inhibitor
84 nt
RNA
PEG-GGAGGGAAAAGUUAUCAGGCCUGAAUUUGGAAUAUACUUGGCUCGUUAGGUGCGUAUAUAGAUUAGUUUUGGAGUACUCGCUCC
HS02-88
Activated
protein C
88 nt
DNA
GCCTGTTGTGAGCCTCCTAACTGAGCTGTACTCGACTTATCCCGGATGGGGCTCTTATGAGGCGCGACCATGCTTATTCTTGTCTCCC