4 Aptamer-Based Drug Delivery Systems
99
[110]. In the presence of transfection reagent group, the DNA prism exhibited the
highest knockdown efficiency when carrying three aptamers and three Rab26 siRNA.
Further introducing functional nucleic acid component can confer DNA hydrogel
many dynamic behaviors [111].
Besides as carrier for gene therapeutic molecules, the hydrogel also received wide
application in delivering anticancer drugs or combinational therapeutic molecules
including anticancer drugs and gene molecules. Early in 2013, Wu et al. [112]
constructed aptamer-modified DNA nanoassembly where X-shaped DNA served
as the core connector to link various Y-shaped functional DNAs bearing targeting
aptamers, intercalated anticancer drugs, and therapeutic antisense oligonucleotides
(Fig. 4.8a). Modifying the basic nanostructure with acrydite groups allowed their
Fig. 4.8 a Photo-crosslinked DNA nanostructures containing targeting aptamers, intercalated anticancer drugs, and therapeutic antisense oligonucleotides. Reprinted with permission from Ref. [112]
Copyright 2013, American Chemical Society. b The construction and working mechanism of DNA
dendrimers assembled from Y-shaped DNA scaffolds. Reprinted with permission from Ref. [113]
Copyright 2015, Springer Nature. c Schematic diagram of the synthesis and action procedure of
CpG-MUC1-hydrogel/DOX. Reprinted with permission from Ref. [116] Copyright 2019, American
Chemical Society. d Multivalent aptamer system in which multiple aptamers were linked together
by rolling circle amplification (RCA) and drugs were then physically encapsulated. Reprinted with
permission from Ref. [117] Copyright 2019, American Chemical Society. e DNA nanosponge fabricated via RCA for chemo-gene combination therapy. Reprinted with permission from Ref. [118]
Copyright 2019, American Chemical Society. f Self-assembled RNA-triple helix hydrogel as drug
delivery system. Reprinted with permission from Ref. [119] Copyright 2020, The Royal Society of
Chemistry
99
[110]. In the presence of transfection reagent group, the DNA prism exhibited the
highest knockdown efficiency when carrying three aptamers and three Rab26 siRNA.
Further introducing functional nucleic acid component can confer DNA hydrogel
many dynamic behaviors [111].
Besides as carrier for gene therapeutic molecules, the hydrogel also received wide
application in delivering anticancer drugs or combinational therapeutic molecules
including anticancer drugs and gene molecules. Early in 2013, Wu et al. [112]
constructed aptamer-modified DNA nanoassembly where X-shaped DNA served
as the core connector to link various Y-shaped functional DNAs bearing targeting
aptamers, intercalated anticancer drugs, and therapeutic antisense oligonucleotides
(Fig. 4.8a). Modifying the basic nanostructure with acrydite groups allowed their
Fig. 4.8 a Photo-crosslinked DNA nanostructures containing targeting aptamers, intercalated anticancer drugs, and therapeutic antisense oligonucleotides. Reprinted with permission from Ref. [112]
Copyright 2013, American Chemical Society. b The construction and working mechanism of DNA
dendrimers assembled from Y-shaped DNA scaffolds. Reprinted with permission from Ref. [113]
Copyright 2015, Springer Nature. c Schematic diagram of the synthesis and action procedure of
CpG-MUC1-hydrogel/DOX. Reprinted with permission from Ref. [116] Copyright 2019, American
Chemical Society. d Multivalent aptamer system in which multiple aptamers were linked together
by rolling circle amplification (RCA) and drugs were then physically encapsulated. Reprinted with
permission from Ref. [117] Copyright 2019, American Chemical Society. e DNA nanosponge fabricated via RCA for chemo-gene combination therapy. Reprinted with permission from Ref. [118]
Copyright 2019, American Chemical Society. f Self-assembled RNA-triple helix hydrogel as drug
delivery system. Reprinted with permission from Ref. [119] Copyright 2020, The Royal Society of
Chemistry