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et al (2011) In vitro evidence for immune evasion activity by human plasmin associated to
pathogenic Leptospira interrogans. Microb
Pathog 51:360–365. https://doi.org/10.
1016/j.micpath.2011.06.008
11. Castiblanco-Valencia MM, Fraga TR, Pagotto
AH et al (2016) Plasmin cleaves fibrinogen and
the human complement proteins C3b and C5
in the presence of Leptospira interrogans proteins: a new role of LigA and LigB in invasion
and complement immune evasion. Immunobiology 221:679–689. https://doi.org/10.
1016/j.imbio.2016.01.001
12. Roos A, Bouwman LH, Munoz J et al (2003)
Functional characterization of the lectin pathway of complement in human serum. Mol
Immunol 39:655–668. https://doi.org/10.
1016/S0161-5890(02)00254-7
13. Castiblanco-Valencia MM, Fraga TR, Breda
LC et al (2016) Acquisition of negative complement regulators by the saprophyte Leptospira biflexa expressing LigA or LigB confers
enhanced survival in human serum. Immunol
Lett 173:61–68. https://doi.org/10.1016/j.
imlet.2016.03.005
198
Lourdes Isaac and Angela Silva Barbosa