12.3 General Structure Models Interaction of Laser Radiation with a Biotissue
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Study of the Optical Characteristics of Thin Layer of the Biological Sample for
Case In vitro
Input parameters:
n j (λ) + iχ j (λ) is refractive index of the jth layer,
d j is thickness jth layer,
M 1 ,M 2 are the radii of mirrors,
L is the mirror distance.
σ is the standard deviation of the profile of the rough boundary from the unperturbed
boundary
Output parameters:
ω = ω(d j , n j , iχ j , σ )are frequencies of the resonator eigenmodes
Experimental measurement:
χ j (λ) is dependence of the imaginary part of the refractive index
on simulated biological structures for jth layer.
Calculate:
1. n j (λ) is dependence of the real part of the refractive index epidermis
2. χ j (λ) is dependence of the imaginary part of the refractive index epidermis
Simulation of the Thermal Processes for Case In vivo
Input parameters:
n j (λ) + iχ j (λ)is refractive index of the jth layer,
d j is thickness jth layer,
m
k
1 is refractive index of the cytoplasm
m
k
2 is refractive index of the plasma membrane
a
k
1 is the radius of the cytoplasm of kth particle,
a
k
2 is the radius of the plasma membrane of kth particle,
c
j
0 is specific heat capacity jth layer,
Λ
j is heat conductivity coefficient jth layer,
ρ
j is density jth layer,
μ is absorption coefficient,
E o is radiant energy density,
τ p is pulse duration,
ρ blood is density blood,
T blood is temperature blood,
f (t, T ) is the density of the flow of blood into the tissues,
is the reduced heat-transfer coefficient,
T 0 is the initial temperature,
ΔH is enthalpy of activation,
ΔS is entropy of activation,