152
S.-H. Lee and Y. Park
Fig. 7.1 Loudness dependence of auditory evoked potential (LDAEP) could reflect sensitivity
and impulsivity because both reflect serotonin related regulation. Theoretically, LDAEP could be
correlated with emotional and sensory processing sensitivity. Moreover, LDAEP might be associated
with impulsivity, which influences motor and cognitive systems. Cited from the article of Kim et al.
[62]
• Efficiency refers to the efficiency of information processing in the brain.
7.2.3 Loudness Dependence of Auditory Evoked Potential
The loudness dependence of auditory evoked potential (LDAEP) has been suggested
as a valid marker of central serotonergic activity. Empirical studies have found significant inverse correlations between LDAEP and central serotonergic activity, indicating that high LDAEP reflects low levels of serotonergic neurotransmission [53]. The
LDAEP is measured through calculating the amplitude change of the evoked N1/P2
components in response to auditory stimuli that vary in intensity [38], O’neill et al.
[97]. Greater amplitude changes reflect sensitivity to auditory stimuli, which then
again corresponds to the strength of LDAEP. Based on their associations with central
serotonin activity, the relationship between LDAEP and sensitivity (i.e., emotional
and sensory) and impulsivity has been studied [62] (see Fig. 7.1).
Both sensitivity and impulsivity not only are central characteristics of various
psychiatric disorders but they also heavily influence their progression. Impulsivity is
defined as the inability to inhibit inappropriate behaviors [6, 126]. Previous literature
has reported that the serotonin system plays a critical role in behavioral inhibition and
impulsivity [41, 85, 126], and dysregulations of the serotonin system in sub-regions
of the prefrontal cortex are associated with maladaptive behaviors. Considering the
associations between impulsivity and central serotonin system, and serotonin activity and LDAEP, a significant relationship between LDAEP and impulsivity can be
assumed.
Although, the relationship between sensory sensitivity and impulsivity is not conclusive and might differ in various clinical populations, a relationship between the
S.-H. Lee and Y. Park
Fig. 7.1 Loudness dependence of auditory evoked potential (LDAEP) could reflect sensitivity
and impulsivity because both reflect serotonin related regulation. Theoretically, LDAEP could be
correlated with emotional and sensory processing sensitivity. Moreover, LDAEP might be associated
with impulsivity, which influences motor and cognitive systems. Cited from the article of Kim et al.
[62]
• Efficiency refers to the efficiency of information processing in the brain.
7.2.3 Loudness Dependence of Auditory Evoked Potential
The loudness dependence of auditory evoked potential (LDAEP) has been suggested
as a valid marker of central serotonergic activity. Empirical studies have found significant inverse correlations between LDAEP and central serotonergic activity, indicating that high LDAEP reflects low levels of serotonergic neurotransmission [53]. The
LDAEP is measured through calculating the amplitude change of the evoked N1/P2
components in response to auditory stimuli that vary in intensity [38], O’neill et al.
[97]. Greater amplitude changes reflect sensitivity to auditory stimuli, which then
again corresponds to the strength of LDAEP. Based on their associations with central
serotonin activity, the relationship between LDAEP and sensitivity (i.e., emotional
and sensory) and impulsivity has been studied [62] (see Fig. 7.1).
Both sensitivity and impulsivity not only are central characteristics of various
psychiatric disorders but they also heavily influence their progression. Impulsivity is
defined as the inability to inhibit inappropriate behaviors [6, 126]. Previous literature
has reported that the serotonin system plays a critical role in behavioral inhibition and
impulsivity [41, 85, 126], and dysregulations of the serotonin system in sub-regions
of the prefrontal cortex are associated with maladaptive behaviors. Considering the
associations between impulsivity and central serotonin system, and serotonin activity and LDAEP, a significant relationship between LDAEP and impulsivity can be
assumed.
Although, the relationship between sensory sensitivity and impulsivity is not conclusive and might differ in various clinical populations, a relationship between the