specific receptors for IgM such as Fc receptor on the surface of macrophages [52].
IgM-mediated complement activation has been anticipated to be the rate-limiting
step of the ABC phenomenon of PEGylated products.
Fig. 20.1 Cartoon depicting the sequence of events leading from anti-PEG IgM induction to
accelerated blood clearance of PEGylated liposomes. Modified from [15]
20 Immune Response to PEGylated Nanomedicines …
375
IgM-mediated complement activation has been anticipated to be the rate-limiting
step of the ABC phenomenon of PEGylated products.
Fig. 20.1 Cartoon depicting the sequence of events leading from anti-PEG IgM induction to
accelerated blood clearance of PEGylated liposomes. Modified from [15]
20 Immune Response to PEGylated Nanomedicines …
375