experiment of mixing the zwitterion coated nanoparticle with serum and at last by
in vivo experiment of proteomics analysis of systemically injected zwitterion coated
nanoparticles.
Zwitterion-modification of nanoparticles were recently reported by several
groups for small iron oxide, silica or gold nanoparticles [35, 50–54]. Sulfobetaine
small molecule [35, 52, 54], carboxybetaine small molecule [53] or polymeric
carboxybetaine or sulfobetaine were used to coat the nanoparticles. Interestingly,
Fig. 18.6 Zwitterionic polymeric materials made of sulfobetaines and carboxybetaines and their
molecular dynamics showing hydration, abhorrence of self-aggregation, and resistance to
nonspecific protein adsorption. Adapted modified from [36] with permission
338
D. S. Lee and Y.-S. Lee
in vivo experiment of proteomics analysis of systemically injected zwitterion coated
nanoparticles.
Zwitterion-modification of nanoparticles were recently reported by several
groups for small iron oxide, silica or gold nanoparticles [35, 50–54]. Sulfobetaine
small molecule [35, 52, 54], carboxybetaine small molecule [53] or polymeric
carboxybetaine or sulfobetaine were used to coat the nanoparticles. Interestingly,
Fig. 18.6 Zwitterionic polymeric materials made of sulfobetaines and carboxybetaines and their
molecular dynamics showing hydration, abhorrence of self-aggregation, and resistance to
nonspecific protein adsorption. Adapted modified from [36] with permission
338
D. S. Lee and Y.-S. Lee