Part VI
Factors Affecting Biodistribution
and Their Consequences
Chapter 17: Size-, Shape- and Charge-dependent Pharmacokinetics of Radiolabeled
Nanoparticles
Chapter 18: PEGylation and the Similar
Chapter 19: Excretion and Clearance
In this part, radiolabeled nanoparticles are at most the radionuclide labeled nanomaterials with various sizes, shapes, charges, and hydrophilicity and affinity for
hard or soft corona proteins in the plasma. If the readers understand the effects of
the factors affecting the in vivo fates of the nanomaterials, then the biodistribution
and final disposal of radionanomaterials are easily predicted. What really matters
are the lack of knowledge of the effects of each factor affecting the biodistribution
of nanomaterials. If the procedures of surface modification and radiolabeling are
standardized and production of size-varied, shape-characterized, charge-measured
and variously hydrophilized with PEGs or zwitterions are to be realized, then the
consequences of these factors and further corona modification of these radionanomaterials are to be examined. The easy and standardized surface modification
and acquisition of homogenous final products of radionanomaterials will enable us
to understand the effects of the factors just like making multidimensional periodic
tables to explain the in vivo behavior of radionanomaterials.
Fortunately, the traceability of radionanomaterials in vivo in animals first and
then in humans later will greatly increase the chances of reaching the goal of the
most desired combination of factors to yield the best product as reasonably fabricable. Chapter 17 explained the effect of factors in common for any nanomaterials
such as size, shape, and charge. Chapter 18 explained the effect of hydrophilization
using PEGs and zwitterions. Further subtle effect of corona wrapping of PEGylated
size, shape, and charge-controlled nanomaterials in vivo was touched upon in every
chapter, if systemically injected, upon the biodistribution of nanomaterials. Corona
wrapping of radionanomaterials is to be examined in a similar setting of experiments. Chapter 19 finally summarized the clearance and excretion of nanomaterials
Factors Affecting Biodistribution
and Their Consequences
Chapter 17: Size-, Shape- and Charge-dependent Pharmacokinetics of Radiolabeled
Nanoparticles
Chapter 18: PEGylation and the Similar
Chapter 19: Excretion and Clearance
In this part, radiolabeled nanoparticles are at most the radionuclide labeled nanomaterials with various sizes, shapes, charges, and hydrophilicity and affinity for
hard or soft corona proteins in the plasma. If the readers understand the effects of
the factors affecting the in vivo fates of the nanomaterials, then the biodistribution
and final disposal of radionanomaterials are easily predicted. What really matters
are the lack of knowledge of the effects of each factor affecting the biodistribution
of nanomaterials. If the procedures of surface modification and radiolabeling are
standardized and production of size-varied, shape-characterized, charge-measured
and variously hydrophilized with PEGs or zwitterions are to be realized, then the
consequences of these factors and further corona modification of these radionanomaterials are to be examined. The easy and standardized surface modification
and acquisition of homogenous final products of radionanomaterials will enable us
to understand the effects of the factors just like making multidimensional periodic
tables to explain the in vivo behavior of radionanomaterials.
Fortunately, the traceability of radionanomaterials in vivo in animals first and
then in humans later will greatly increase the chances of reaching the goal of the
most desired combination of factors to yield the best product as reasonably fabricable. Chapter 17 explained the effect of factors in common for any nanomaterials
such as size, shape, and charge. Chapter 18 explained the effect of hydrophilization
using PEGs and zwitterions. Further subtle effect of corona wrapping of PEGylated
size, shape, and charge-controlled nanomaterials in vivo was touched upon in every
chapter, if systemically injected, upon the biodistribution of nanomaterials. Corona
wrapping of radionanomaterials is to be examined in a similar setting of experiments. Chapter 19 finally summarized the clearance and excretion of nanomaterials