Chapter 9
Endogenous Radionanomedicine:
Validation of Therapeutic Potential
Seunggyun Ha and Dong Soo Lee
Abstract Exosomes have features to be able to promise therapeutic opportunities,
which are exosomes-mediated pathogenesis in certain diseases, and thus their
inherent therapeutic potential, and again possibility of use of exosomes as drug
carriers. There have been increasing interests in this therapeutic potential of exosomes owing to the recent reports in regenerative medicine, tumor management,
infection, and organ transplantation. Radionanomedicines i.e. radiolabeled exosomes provide advantages of non-invasive, less toxic, highly penetrable, highly
sensitive, and quantification-enabling characteristic of radioactivity for validation of
therapeutic potentials of exosomes. Radiolabeled exosomes are expected to allow
their theranostic use even in clinical settings. However, there remain the issues to
overcome the low yields of exosomes, release of free radioisotope after degradation
of exosomes, and yet unveiled dosimetry of therapeutic radiolabeled exosomes.
This chapter reviews current evidences of therapeutic applications of exosomes in
regenerative medicine and tumor management and discusses radiolabeled exosomes
or exosome-mimetic nanovesicles as well as remaining issues in endogenous
radionanomedicines regarding the desired therapeutic potentials of radiolabeled or
unlabeled exosomes.
S. Ha (&) Á D. S. Lee
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul 03080, Republic of Korea
e-mail: gyuriha@snu.ac.kr
S. Ha Á D. S. Lee
Department of Molecular Medicine and Biopharmaceutical Sciences,
Graduate School of Convergence Science and Technology, Seoul National University,
Seoul 03080, Republic of Korea
D. S. Lee
Korea Brain Research Institute, Daegu, Republic of Korea
e-mail: dsl@snu.ac.kr
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_9
167
Endogenous Radionanomedicine:
Validation of Therapeutic Potential
Seunggyun Ha and Dong Soo Lee
Abstract Exosomes have features to be able to promise therapeutic opportunities,
which are exosomes-mediated pathogenesis in certain diseases, and thus their
inherent therapeutic potential, and again possibility of use of exosomes as drug
carriers. There have been increasing interests in this therapeutic potential of exosomes owing to the recent reports in regenerative medicine, tumor management,
infection, and organ transplantation. Radionanomedicines i.e. radiolabeled exosomes provide advantages of non-invasive, less toxic, highly penetrable, highly
sensitive, and quantification-enabling characteristic of radioactivity for validation of
therapeutic potentials of exosomes. Radiolabeled exosomes are expected to allow
their theranostic use even in clinical settings. However, there remain the issues to
overcome the low yields of exosomes, release of free radioisotope after degradation
of exosomes, and yet unveiled dosimetry of therapeutic radiolabeled exosomes.
This chapter reviews current evidences of therapeutic applications of exosomes in
regenerative medicine and tumor management and discusses radiolabeled exosomes
or exosome-mimetic nanovesicles as well as remaining issues in endogenous
radionanomedicines regarding the desired therapeutic potentials of radiolabeled or
unlabeled exosomes.
S. Ha (&) Á D. S. Lee
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul 03080, Republic of Korea
e-mail: gyuriha@snu.ac.kr
S. Ha Á D. S. Lee
Department of Molecular Medicine and Biopharmaceutical Sciences,
Graduate School of Convergence Science and Technology, Seoul National University,
Seoul 03080, Republic of Korea
D. S. Lee
Korea Brain Research Institute, Daegu, Republic of Korea
e-mail: dsl@snu.ac.kr
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_9
167