Chapter 6
Endogenous Radionanomedicine:
Extracellular Vesicles
Changjin Lee, Do Won Hwang and Yong Song Gho
Abstract Extracellular vesicles are bilayered proteolipids ranging from 30 to
1000 nm in diameter. All cells of three domains of life on earth actively shed
extracellular vesicles to the surrounding environments including various biological
body fluids. Moreover, extracellular vesicles harbor specific subsets of cellular
bioactive molecules including proteins, lipids, mRNAs, miRNAs, and metabolites.
During last decade, explosively growing evidences are supporting the emerging
roles of these complex extracellular organelles as endogenous and environmental
nanocarriers by carrying specific subsets of bioactive cargos: extracellular
vesicle-mediated intercellular communication is evolutionarily conserved phenomenon. Furthermore, extracellular vesicles are novel targets for diagnostics and
therapeutics. Thus, a future comprehensive understanding of extracellular
vesicle-mediated intercellular communication including their complex pathophysiological functions is critical to decode the secrets of life and to develop novel
extracellular vesicle-based diagnostics and therapeutics against hard-to-cure diseases
such as cancer. Here, we briefly review history, biogenesis, pathophysiological
C. Lee Á Y. S. Gho (&)
Department of Life Sciences, Pohang University of Science
and Technology (POSTECH), Pohang 37673, Republic of Korea
e-mail: ysgho@postech.ac.kr
D. W. Hwang
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul, Republic of Korea
D. W. Hwang
Department of Molecular Medicine and Biopharmaceutical Sciences,
Graduate School of Convergence Science and Technology,
College of Medicine or College of Pharmacy,
Seoul National University, Seoul, Republic of Korea
Y. S. Gho
The Krefting Research Centre, Institute of Medicine,
University of Gothenburg, Gothenburg, Sweden
Y. S. Gho
Exosome BioSciences Inc., Pohang, Republic of Korea
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_6
127
Endogenous Radionanomedicine:
Extracellular Vesicles
Changjin Lee, Do Won Hwang and Yong Song Gho
Abstract Extracellular vesicles are bilayered proteolipids ranging from 30 to
1000 nm in diameter. All cells of three domains of life on earth actively shed
extracellular vesicles to the surrounding environments including various biological
body fluids. Moreover, extracellular vesicles harbor specific subsets of cellular
bioactive molecules including proteins, lipids, mRNAs, miRNAs, and metabolites.
During last decade, explosively growing evidences are supporting the emerging
roles of these complex extracellular organelles as endogenous and environmental
nanocarriers by carrying specific subsets of bioactive cargos: extracellular
vesicle-mediated intercellular communication is evolutionarily conserved phenomenon. Furthermore, extracellular vesicles are novel targets for diagnostics and
therapeutics. Thus, a future comprehensive understanding of extracellular
vesicle-mediated intercellular communication including their complex pathophysiological functions is critical to decode the secrets of life and to develop novel
extracellular vesicle-based diagnostics and therapeutics against hard-to-cure diseases
such as cancer. Here, we briefly review history, biogenesis, pathophysiological
C. Lee Á Y. S. Gho (&)
Department of Life Sciences, Pohang University of Science
and Technology (POSTECH), Pohang 37673, Republic of Korea
e-mail: ysgho@postech.ac.kr
D. W. Hwang
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul, Republic of Korea
D. W. Hwang
Department of Molecular Medicine and Biopharmaceutical Sciences,
Graduate School of Convergence Science and Technology,
College of Medicine or College of Pharmacy,
Seoul National University, Seoul, Republic of Korea
Y. S. Gho
The Krefting Research Centre, Institute of Medicine,
University of Gothenburg, Gothenburg, Sweden
Y. S. Gho
Exosome BioSciences Inc., Pohang, Republic of Korea
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_6
127