Chapter 5
Organic Nanomaterials: Liposomes,
Albumin, Dendrimer, Polymeric
Nanoparticles
Keon Wook Kang and Myung Geun Song
Abstract Organic nanoparticles (NPs) as a drug delivery system have a relative
long history of development and many of them are now approved for commercial
use. The nano-carrier used for drug delivery should be eliminated from the body,
either by degradation or by excretion. While many inorganic nano-carriers are very
stable and difficult to metabolize, many of organic NPs are biodegradable.
Radiolabeling of biomolecules enables tracing these molecules in vivo.
Biodistribution and autoradiography studies validate tissue distribution of the
nano-carriers in animals. Nuclear medicine imaging such as single photon emission
computed tomography (SPECT) or positron emission tomography (PET) allows
non-invasive longitudinal monitoring of the in vivo pharmacokinetics and tissue
distribution of the nano-carriers even in human subjects. In vivo tracking of
nano-carriers using radionuclide imaging techniques enables a theranostic approach
as well, not just being a drug carrier. The combination of diagnostic and therapeutic
capabilities in a single drug delivery system can be used for precision personalized
therapies. In this chapter, we dealt with four different groups of biodegradable
organic NPs and their radiolabeled forms: liposomes, albumin-based nanoparticles,
dendrimers, and polymeric nanoparticles.
K. W. Kang (&) Á M. G. Song
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul 03080, Republic of Korea
e-mail: kangkw@snu.ac.kr
K. W. Kang Á M. G. Song
Cancer Research Institute, Seoul National University,
Seoul, Republic of Korea
M. G. Song
Biomedical Research Institute, Seoul National University Hospital,
Seoul 03082, Republic of Korea
e-mail: mgsong0310@snu.ac.kr
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_5
105
Organic Nanomaterials: Liposomes,
Albumin, Dendrimer, Polymeric
Nanoparticles
Keon Wook Kang and Myung Geun Song
Abstract Organic nanoparticles (NPs) as a drug delivery system have a relative
long history of development and many of them are now approved for commercial
use. The nano-carrier used for drug delivery should be eliminated from the body,
either by degradation or by excretion. While many inorganic nano-carriers are very
stable and difficult to metabolize, many of organic NPs are biodegradable.
Radiolabeling of biomolecules enables tracing these molecules in vivo.
Biodistribution and autoradiography studies validate tissue distribution of the
nano-carriers in animals. Nuclear medicine imaging such as single photon emission
computed tomography (SPECT) or positron emission tomography (PET) allows
non-invasive longitudinal monitoring of the in vivo pharmacokinetics and tissue
distribution of the nano-carriers even in human subjects. In vivo tracking of
nano-carriers using radionuclide imaging techniques enables a theranostic approach
as well, not just being a drug carrier. The combination of diagnostic and therapeutic
capabilities in a single drug delivery system can be used for precision personalized
therapies. In this chapter, we dealt with four different groups of biodegradable
organic NPs and their radiolabeled forms: liposomes, albumin-based nanoparticles,
dendrimers, and polymeric nanoparticles.
K. W. Kang (&) Á M. G. Song
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul 03080, Republic of Korea
e-mail: kangkw@snu.ac.kr
K. W. Kang Á M. G. Song
Cancer Research Institute, Seoul National University,
Seoul, Republic of Korea
M. G. Song
Biomedical Research Institute, Seoul National University Hospital,
Seoul 03082, Republic of Korea
e-mail: mgsong0310@snu.ac.kr
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_5
105