Chapter 4
Graphene-Based Nanomaterials
Je Min Yoo, Do Won Hwang and Byung Hee Hong
Abstract Graphenes are unique nanomaterials which was recently made compatible for physiological milieu, and thus find a way to be used as nanocarriers. The
surface engineering abilities of nano-graphene oxides (nano-GOs) or graphene
quantum dots (GQDs) in their own outstanding photoluminescence property have
made it possible to be used for imaging or drug delivery. Though many successes
were not reported in the application of GQDs in vivo, toxicity and safety of GOs
in vitro and in vivo are being investigated. Interestingly, GOs are found to be
degraded in vivo. In addition to much effort to use GOs as drug carriers, there have
been recent trials to apply GOs for magnetic resonance imaging (MRI) and positron
emission tomography (PET) or even multiplexed imaging with MRI/fluorescence or
MRI/PET. The product has the composition of chelator-conjugated GOs loaded
with iron oxide nanoparticles, and a variety of radionuclides such as
68 Ga,
64 Cu or
125 I and
131 I and
177 Lu were used for PET or SPECT imaging and for radionuclide
J. M. Yoo Á B. H. Hong (&)
Department of Chemistry, College of Natural Science,
Seoul National University, Seoul, Republic of Korea
e-mail: byunghee@snu.ac.kr
J. M. Yoo
e-mail: jyoo1130@snu.ac.kr
B. H. Hong
Program in Nano Science and Technology, Graduate School of Convergence
Science and Technology, Seoul National University, Seoul, Republic of Korea
D. W. Hwang
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul, Republic of Korea
e-mail: hdw6592@snu.ac.kr
D. W. Hwang
Department of Molecular Medicine and Biopharmaceutical Sciences,
Graduate School of Convergence Science and Technology,
College of Medicine or College of Pharmacy,
Seoul National University, Seoul, Republic of Korea
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_4
79
Graphene-Based Nanomaterials
Je Min Yoo, Do Won Hwang and Byung Hee Hong
Abstract Graphenes are unique nanomaterials which was recently made compatible for physiological milieu, and thus find a way to be used as nanocarriers. The
surface engineering abilities of nano-graphene oxides (nano-GOs) or graphene
quantum dots (GQDs) in their own outstanding photoluminescence property have
made it possible to be used for imaging or drug delivery. Though many successes
were not reported in the application of GQDs in vivo, toxicity and safety of GOs
in vitro and in vivo are being investigated. Interestingly, GOs are found to be
degraded in vivo. In addition to much effort to use GOs as drug carriers, there have
been recent trials to apply GOs for magnetic resonance imaging (MRI) and positron
emission tomography (PET) or even multiplexed imaging with MRI/fluorescence or
MRI/PET. The product has the composition of chelator-conjugated GOs loaded
with iron oxide nanoparticles, and a variety of radionuclides such as
68 Ga,
64 Cu or
125 I and
131 I and
177 Lu were used for PET or SPECT imaging and for radionuclide
J. M. Yoo Á B. H. Hong (&)
Department of Chemistry, College of Natural Science,
Seoul National University, Seoul, Republic of Korea
e-mail: byunghee@snu.ac.kr
J. M. Yoo
e-mail: jyoo1130@snu.ac.kr
B. H. Hong
Program in Nano Science and Technology, Graduate School of Convergence
Science and Technology, Seoul National University, Seoul, Republic of Korea
D. W. Hwang
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul, Republic of Korea
e-mail: hdw6592@snu.ac.kr
D. W. Hwang
Department of Molecular Medicine and Biopharmaceutical Sciences,
Graduate School of Convergence Science and Technology,
College of Medicine or College of Pharmacy,
Seoul National University, Seoul, Republic of Korea
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_4
79