applications. Wiley Interdiscip Rev Comput
Mol Sci 7(4):e1311
23. Wells SA, Menor S, Hespenheide BM, Thorpe
MF (2005) Constrained geometric simulation
of difusive motion in proteins. Phys Biol 2:
S12736
24. Zhu S, Shala A, Bezginov A, Sljoka A,
Audette G, Wilson D (2015) Hyperphosphorylation of intrinsically disordered tau protein
induces an amyloidogenic shift in its conformational ensemble. PLoS One 10(3):e0120416
25. Sljoka A, Shai O, Whiteley W (2011) Checking
mobility and decomposition of linkages via
pebble game algorithm. In: Proceedings of
the ASME 2011 international design engineering technical conferences and computers and
information in engineering conference,
IDETC/CIE 2011
26. Tay TS (1984) Rigidity of multigraphs I: linking rigid bodies in n-space. J Combinat Theor
Ser B 26:95–112
27. Lee A, Streinu I (2008) Pebble game algorithms and sparse graphs. Discret Math 308
(1425):1437
28. Hespenheide BM, Jacobs DJ, Thorpe MF
(2004) Structural rigidity in the capsid assembly of cowpea chlorotic mottle virus. J Phys 16:
S5055–S5064
29. Prosser RS, Ye L, Pandey A, Orazietti A (2017)
Activation processes in ligand-activated G
protein-coupled receptors: a case study of the
adenosine
A 2A
receptor.
BioEssays
39:1700072
30. Leach K, Sexton PM, Christopoulos A (2007)
Allosteric GPCR modulators: taking advantage
of permissive receptor pharmacology. Trends
Pharmacol Sci 28(8):382–389
31. Lebon G, Warne T, Edwards PC, Bennett K,
Langmead CJ, Leslie AGW, Tate CG (2011)
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation. Nature 474:521
32. Xu F, Wu H, Katritch V, Han GW, Jacobson
KA, Gao ZG, Cherezov V, Stevens RC (2011)
Structure of an agonist-bound human A2A
adenosine receptor. Science 332:322
33. Staus DP et al (2016) Allosteric nanobodies
reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
Nature 535(7612):448–452
34. Tehan BG, Bortolato A, Blaney FE, Weir MP,
Mason JS (2014) Unifying family A GPCR
theories of activation. Pharmacol Ther 143
(1):51–60
35. Ye L et al (2016) Activation of the A 2A adenosine G-protein-coupled receptor by conformational selection. Nature 533(7602):265–268
36. Chen JF (2014) Adenosine receptor control of
cognition in normal and disease. In: Mori A
(ed) Adenosine receptors in neurology and psychiatry, International review of neurobiology,
vol 119. Academic, Cambridge, pp 257–307
Probing Allosteric Mechanism with Rigidity Transmission
75
Mol Sci 7(4):e1311
23. Wells SA, Menor S, Hespenheide BM, Thorpe
MF (2005) Constrained geometric simulation
of difusive motion in proteins. Phys Biol 2:
S12736
24. Zhu S, Shala A, Bezginov A, Sljoka A,
Audette G, Wilson D (2015) Hyperphosphorylation of intrinsically disordered tau protein
induces an amyloidogenic shift in its conformational ensemble. PLoS One 10(3):e0120416
25. Sljoka A, Shai O, Whiteley W (2011) Checking
mobility and decomposition of linkages via
pebble game algorithm. In: Proceedings of
the ASME 2011 international design engineering technical conferences and computers and
information in engineering conference,
IDETC/CIE 2011
26. Tay TS (1984) Rigidity of multigraphs I: linking rigid bodies in n-space. J Combinat Theor
Ser B 26:95–112
27. Lee A, Streinu I (2008) Pebble game algorithms and sparse graphs. Discret Math 308
(1425):1437
28. Hespenheide BM, Jacobs DJ, Thorpe MF
(2004) Structural rigidity in the capsid assembly of cowpea chlorotic mottle virus. J Phys 16:
S5055–S5064
29. Prosser RS, Ye L, Pandey A, Orazietti A (2017)
Activation processes in ligand-activated G
protein-coupled receptors: a case study of the
adenosine
A 2A
receptor.
BioEssays
39:1700072
30. Leach K, Sexton PM, Christopoulos A (2007)
Allosteric GPCR modulators: taking advantage
of permissive receptor pharmacology. Trends
Pharmacol Sci 28(8):382–389
31. Lebon G, Warne T, Edwards PC, Bennett K,
Langmead CJ, Leslie AGW, Tate CG (2011)
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation. Nature 474:521
32. Xu F, Wu H, Katritch V, Han GW, Jacobson
KA, Gao ZG, Cherezov V, Stevens RC (2011)
Structure of an agonist-bound human A2A
adenosine receptor. Science 332:322
33. Staus DP et al (2016) Allosteric nanobodies
reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
Nature 535(7612):448–452
34. Tehan BG, Bortolato A, Blaney FE, Weir MP,
Mason JS (2014) Unifying family A GPCR
theories of activation. Pharmacol Ther 143
(1):51–60
35. Ye L et al (2016) Activation of the A 2A adenosine G-protein-coupled receptor by conformational selection. Nature 533(7602):265–268
36. Chen JF (2014) Adenosine receptor control of
cognition in normal and disease. In: Mori A
(ed) Adenosine receptors in neurology and psychiatry, International review of neurobiology,
vol 119. Academic, Cambridge, pp 257–307
Probing Allosteric Mechanism with Rigidity Transmission
75