this chapter asks for the need for a fresh approach to the study of this protein, encompassing
a more integrated and systemic attitude.
Chapter 14 introduces the most direct applicative dimension of the network-based
approaches to allostery, introducing a totally new approach to pharmacology: allosteric
drug paradigm that promises to make pharmacological research to exit from a bottleneck
lasting since at least two decades.
Chapter 15 constitutes a (largely unexpected) widening of the perspective telling us not
only proteins but even RNA systems display allosteric and cooperative features. Besides the
applicative value for exploiting gene expression regulation, these findings open the way to
very stimulating hypotheses about an RNA world at the very origin of life.
We can safely state that the authors contributing to this book are representatives of the
frontiers of integrated approaches to protein science and the picture emerging is in turn
coherent and fully integrated, thus contributing to the recovery from the fragmentation of
scientific thought that is probably the most dangerous menace facing science in these times.
Rome, Italy
Luisa Di Paola
Alessandro Giuliani
Preface
vii
a more integrated and systemic attitude.
Chapter 14 introduces the most direct applicative dimension of the network-based
approaches to allostery, introducing a totally new approach to pharmacology: allosteric
drug paradigm that promises to make pharmacological research to exit from a bottleneck
lasting since at least two decades.
Chapter 15 constitutes a (largely unexpected) widening of the perspective telling us not
only proteins but even RNA systems display allosteric and cooperative features. Besides the
applicative value for exploiting gene expression regulation, these findings open the way to
very stimulating hypotheses about an RNA world at the very origin of life.
We can safely state that the authors contributing to this book are representatives of the
frontiers of integrated approaches to protein science and the picture emerging is in turn
coherent and fully integrated, thus contributing to the recovery from the fragmentation of
scientific thought that is probably the most dangerous menace facing science in these times.
Rome, Italy
Luisa Di Paola
Alessandro Giuliani
Preface
vii